Cytogenetic investigation of chromosomal aberrations in cells treated with plantamajoside from Plantago asiatica

Yun Chang Koo, Sung Hoon Jung, Ji Hee Yang, Yung Sun Ryu, Eun Jin Kim, Kwang Won Lee

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Plantago asiatica is a member of the Plantaginaceae family, and is widely distributed in East Asia. In our previous work, a single active compound, plantamajoside was isolated and confirmed to have glycation inhibitory activity, and did not possess toxicity during a 90 day repeated oral toxicity test in rats. In the present study, a chromosomal aberration test was performed to investigate the genotoxicity of plantamajoside. From the results of the cytotoxicity test, plantamajoside proved to be less toxic when it was treated combined with S9 cell fractions. However, there was a significant increase in structural aberrations during the short-term treatment of plantamajoside at its highest dose (5000 μg/mL) even when combined with S9. This seems to have been a natural phenomenon due to the very high dose of plantamajoside that was used. However, to confirm the safety of plantamajoside for its potential use as a phytochemical agent in health products, additional mutagenicity tests are necessary.

Original languageEnglish
Pages (from-to)1479-1481
Number of pages3
JournalPhytotherapy Research
Volume23
Issue number10
DOIs
Publication statusPublished - 2009 Oct

Keywords

  • Chromosomal aberration
  • Genotoxicity
  • Plantago asiatica
  • Plantamajoside

ASJC Scopus subject areas

  • Pharmacology

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