Cytogenetics of bone tumors

Ji-Yun Lee, Andrea R. Sternenberger, Shibo Li

Research output: Chapter in Book/Report/Conference proceedingChapter


The presence or absence of specific cytogenetic rearrangements has been routinely used to classify hematological neoplastic disorders, as well as to provide management guidance, and to predict the outcome of these hematological disorders. Compared to hematological neoplastic disorders, the cytogenetic data of bone tumors is limited. This is due in part to the fact that bone tumors are extremely rare; they represent only 0.2% of all human malignancies, and it is more challenging to perform a chromosome analysis of a bone tumor. Also, it is extremely difficult, sometimes impossible, to analyze intratumoral karyotypic heterogeneity in bone tumors. Here, we intend to provide the current status of the cytogenetic aspects of bone tumors.

Original languageEnglish
Title of host publicationBone Cancer
Subtitle of host publicationPrimary Bone Cancers and Bone Metastases: Second Edition
PublisherElsevier Inc.
Number of pages11
ISBN (Electronic)9780124167285
ISBN (Print)9780124167216
Publication statusPublished - 2014 Aug 27


  • Bone cancer
  • Bone tumor
  • Cytogenetics

ASJC Scopus subject areas

  • Medicine(all)

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