Cytogenetics of bone tumors

Ji-Yun Lee, Mallory Martin, Shibo Li

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The mechanism of bone tumor development is complex and largely unknown. This chapter summarizes the current status of cytogenetic changes in bone tumors. However routine, traditional cytogenetics has its limitations in identifying chromosomal changes in bone tumors. As an adjunct tool, array comparative genomic hybridization (CGH) technology should be used to identify subtle deletions and duplications that reveal gene(s) responsible for some of these bone tumors. Osteochondroma is the most common benign bone tumor, often found in patients under the age of 20 years. The majority of cases (85%) of osteochondroma present as sporadic, solitary, non-hereditary lesions. Osteoid osteoma is a benign bone-forming tumor characterized by small size, limited growth potential and disproportionate pain. Benign fibrous histiocytoma of bone is a benign lesion of bone composed of spindle-shaped fibroblasts, arranged in a storiform pattern. The giant cell tumor is a benign, locally aggressive neoplasm composed of sheets of neoplastic ovoid mononuclear cells interspersed with uniformly distributed osteoclast-like giant cells. Cytogenetics revealed telomeric association or telomeric fusion in more than 75% of patients with a giant cell tumor of bone.

Original languageEnglish
Title of host publicationBone Cancer
PublisherElsevier Inc.
Pages151-159
Number of pages9
ISBN (Print)9780123748959
DOIs
Publication statusPublished - 2010 Dec 1
Externally publishedYes

Fingerprint

Cytogenetics
Bone and Bones
Neoplasms
Osteochondroma
Giant Cell Tumor of Bone
Benign Fibrous Histiocytoma
Osteoid Osteoma
Giant Cell Tumors
Gene Duplication
Comparative Genomic Hybridization
Bone Development
Osteoclasts
Giant Cells
Fibroblasts
Technology
Pain
Growth

ASJC Scopus subject areas

  • Dentistry(all)
  • Medicine(all)

Cite this

Lee, J-Y., Martin, M., & Li, S. (2010). Cytogenetics of bone tumors. In Bone Cancer (pp. 151-159). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-374895-9.00012-8

Cytogenetics of bone tumors. / Lee, Ji-Yun; Martin, Mallory; Li, Shibo.

Bone Cancer. Elsevier Inc., 2010. p. 151-159.

Research output: Chapter in Book/Report/Conference proceedingChapter

Lee, J-Y, Martin, M & Li, S 2010, Cytogenetics of bone tumors. in Bone Cancer. Elsevier Inc., pp. 151-159. https://doi.org/10.1016/B978-0-12-374895-9.00012-8
Lee J-Y, Martin M, Li S. Cytogenetics of bone tumors. In Bone Cancer. Elsevier Inc. 2010. p. 151-159 https://doi.org/10.1016/B978-0-12-374895-9.00012-8
Lee, Ji-Yun ; Martin, Mallory ; Li, Shibo. / Cytogenetics of bone tumors. Bone Cancer. Elsevier Inc., 2010. pp. 151-159
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