Abstract
There are different theories and hypotheses related to the aetiology of depression. The interaction between brain 5-HT level and the activity of its autoreceptors plays a role in mood changes and depression. In major depression, activation of the inflammatory response system (IRS) and, increased concentrations of proinflammatory cytokines, prostaglandin E2 and negative immuno-regulatory cytokines in peripheral blood have been reported. Recently, pro-inflammatory cytokines have been found to have profound effects on the metabolism of brain serotonin through the enzyme indoleamine-2,3-dioxygenase (IDO) that metabolizes the tryptophan, the precursor of 5-HT to neurodegenerative quinolinate and neuroprotective kynurenate. The cytokine-serotonin interaction that leads to the challenge between quinolinate and kynurenate in the brain explains the neurodegeneration hypothesis of depression.
| Original language | English |
|---|---|
| Pages (from-to) | 519-525 |
| Number of pages | 7 |
| Journal | Medical Hypotheses |
| Volume | 61 |
| Issue number | 5-6 |
| DOIs | |
| Publication status | Published - 2003 Jan 1 |
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ASJC Scopus subject areas
- Medicine(all)
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Cytokine-serotonin interaction through IDO : A neurodegeneration hypothesis of depression. / Myint, A. M.; Kim, Yong Ku.
In: Medical Hypotheses, Vol. 61, No. 5-6, 01.01.2003, p. 519-525.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cytokine-serotonin interaction through IDO
T2 - A neurodegeneration hypothesis of depression
AU - Myint, A. M.
AU - Kim, Yong Ku
PY - 2003/1/1
Y1 - 2003/1/1
N2 - There are different theories and hypotheses related to the aetiology of depression. The interaction between brain 5-HT level and the activity of its autoreceptors plays a role in mood changes and depression. In major depression, activation of the inflammatory response system (IRS) and, increased concentrations of proinflammatory cytokines, prostaglandin E2 and negative immuno-regulatory cytokines in peripheral blood have been reported. Recently, pro-inflammatory cytokines have been found to have profound effects on the metabolism of brain serotonin through the enzyme indoleamine-2,3-dioxygenase (IDO) that metabolizes the tryptophan, the precursor of 5-HT to neurodegenerative quinolinate and neuroprotective kynurenate. The cytokine-serotonin interaction that leads to the challenge between quinolinate and kynurenate in the brain explains the neurodegeneration hypothesis of depression.
AB - There are different theories and hypotheses related to the aetiology of depression. The interaction between brain 5-HT level and the activity of its autoreceptors plays a role in mood changes and depression. In major depression, activation of the inflammatory response system (IRS) and, increased concentrations of proinflammatory cytokines, prostaglandin E2 and negative immuno-regulatory cytokines in peripheral blood have been reported. Recently, pro-inflammatory cytokines have been found to have profound effects on the metabolism of brain serotonin through the enzyme indoleamine-2,3-dioxygenase (IDO) that metabolizes the tryptophan, the precursor of 5-HT to neurodegenerative quinolinate and neuroprotective kynurenate. The cytokine-serotonin interaction that leads to the challenge between quinolinate and kynurenate in the brain explains the neurodegeneration hypothesis of depression.
UR - http://www.scopus.com/inward/record.url?scp=0242720163&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0242720163&partnerID=8YFLogxK
U2 - 10.1016/S0306-9877(03)00207-X
DO - 10.1016/S0306-9877(03)00207-X
M3 - Article
C2 - 14592780
AN - SCOPUS:0242720163
VL - 61
SP - 519
EP - 525
JO - Medical Hypotheses
JF - Medical Hypotheses
SN - 0306-9877
IS - 5-6
ER -