Cytosolic phospholipase A2, lipoxygenase metabolites, and reactive oxygen species

Cheolminxs Kim, Joo Young Kim, Jae-Hong Kim

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

Reactive oxygen species (ROS) are generated in mammalian cells via both enzymatic and non-enzymatic mechanisms. Although certain ROS production pathways are required for the performance of specific physiological functions, excessive ROS generation is harmful, and has been implicated in the pathogenesis of a number of diseases. Among the ROS-producing enzymes, NADPH oxidase is widely distributed among mammalian cells, and is a crucial source of ROS for physiological and pathological processes. Reactive oxygen species are also generated by arachidonic acid (AA) metabolites, which are released from membrane phospholipids via the activity of cytosolic phospholipase A2 (cPLA2). In this study, we describe recent studies concerning the generation of ROS by AA metabolites. In particular, we have focused on the manner in which AA metabolism via lipoxygenase (LOX) and LOX metabolites contributes to ROS generation. By elucidating the signaling mechanisms that link LOX and LOX metabolites to ROS, we hope to shed light on the variety of physiological and pathological mechanisms associated with LOX metabolism.

Original languageEnglish
Pages (from-to)555-559
Number of pages5
JournalJournal of Biochemistry and Molecular Biology
Volume41
Issue number8
Publication statusPublished - 2008 Aug 1

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Keywords

  • Arachidonic acid
  • Cytosolic phospholipase A
  • Eicosanoids
  • Lipoxygenase
  • Reactive oxygen species

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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