Cytotoxic 6-alkylsalicylic acids from the endophytic Streptomyces laceyi

Nahyun Kim, Jin Chul Shin, Woncheol Kim, Bang Yeon Hwang, Beom Seok Kim, Young Soo Hong, Dongho Lee

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Two new 6-alkylsalicylic acids, salaceyins A and B were isolated by bioassay-guided fractionation from the culture of the endophytic Streptomyces laceyi MS53 and their structures were determined on the basis of spectroscopic data. Salaceyins A and B exhibited modest cytotoxicity against a human breast cancer cell line (SKBR3) with IC50 values of 3.0 and 5.5 μg/ml, respectively.

Original languageEnglish
Pages (from-to)797-800
Number of pages4
JournalJournal of Antibiotics
Volume59
Issue number12
DOIs
Publication statusPublished - 2006 Dec

Keywords

  • Alkysalicylic acid
  • Cytotoxic
  • Streptomyces

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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