Cytotoxic 6-alkylsalicylic acids from the endophytic Streptomyces laceyi

Nahyun Kim, Jin Chul Shin, Woncheol Kim, Bang Yeon Hwang, Beom Seok Kim, Young S. Hong, Dongho Lee

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Two new 6-alkylsalicylic acids, salaceyins A and B were isolated by bioassay-guided fractionation from the culture of the endophytic Streptomyces laceyi MS53 and their structures were determined on the basis of spectroscopic data. Salaceyins A and B exhibited modest cytotoxicity against a human breast cancer cell line (SKBR3) with IC50 values of 3.0 and 5.5 μg/ml, respectively.

Original languageEnglish
Pages (from-to)797-800
Number of pages4
JournalJournal of Antibiotics
Volume59
Issue number12
DOIs
Publication statusPublished - 2006 Dec 1

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Streptomyces
Biological Assay
Inhibitory Concentration 50
Breast Neoplasms
Cell Line
Acids

Keywords

  • Alkysalicylic acid
  • Cytotoxic
  • Streptomyces

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

Cite this

Cytotoxic 6-alkylsalicylic acids from the endophytic Streptomyces laceyi. / Kim, Nahyun; Shin, Jin Chul; Kim, Woncheol; Hwang, Bang Yeon; Kim, Beom Seok; Hong, Young S.; Lee, Dongho.

In: Journal of Antibiotics, Vol. 59, No. 12, 01.12.2006, p. 797-800.

Research output: Contribution to journalArticle

Kim, Nahyun ; Shin, Jin Chul ; Kim, Woncheol ; Hwang, Bang Yeon ; Kim, Beom Seok ; Hong, Young S. ; Lee, Dongho. / Cytotoxic 6-alkylsalicylic acids from the endophytic Streptomyces laceyi. In: Journal of Antibiotics. 2006 ; Vol. 59, No. 12. pp. 797-800.
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