Cytotoxic and Antiangiogenetic Xanthones Inhibiting Tumor Proliferation and Metastasis from Garcinia xipshuanbannaensis

Xuke Zhang, Ziteng Song, Ying Li, Huimei Wang, Shaojie Zhang, Anna Mari Reid, Namrita Lall, Jie Zhang, Chunyan Wang, Dongho Lee, Yasushi Ohizumi, Jing Xu, Yuanqiang Guo

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Eight prenylated xanthones including four new analogues were extracted and purified from the leaves of Garcinia xipshuanbannaensis. Multiple techniques including UV, 1D and 2D NMR, and HRESIMS were used to determine the structures of the isolated xanthones. These xanthones were evaluated for their cytotoxicity toward human cancer cells, and compound 4 exhibited activity against HeLa cells. A cytotoxic mechanism examination revealed the active compound induced cell apoptosis by arresting the cell cycle, increasing the levels of ROS, and inhibiting the expression of p-STAT3 in HeLa cells. In in vivo zebrafish experiments, compound 4 was found to block tumor proliferation and migration and have antiangiogenetic activity, and thus seems worthy of further laboratory evaluation.

Original languageEnglish
JournalJournal of Natural Products
DOIs
Publication statusAccepted/In press - 2020

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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