TY - JOUR
T1 - Cytotoxic and Antiangiogenetic Xanthones Inhibiting Tumor Proliferation and Metastasis from Garcinia xipshuanbannaensis
AU - Zhang, Xuke
AU - Song, Ziteng
AU - Li, Ying
AU - Wang, Huimei
AU - Zhang, Shaojie
AU - Reid, Anna Mari
AU - Lall, Namrita
AU - Zhang, Jie
AU - Wang, Chunyan
AU - Lee, Dongho
AU - Ohizumi, Yasushi
AU - Xu, Jing
AU - Guo, Yuanqiang
N1 - Funding Information:
This research was supported financially by the National Natural Science Foundation of China (Nos. 22077067 and U1801288) and the Natural Science Foundation of Tianjin, China (No. 19JCYBJC28100).
Publisher Copyright:
©
PY - 2020
Y1 - 2020
N2 - Eight prenylated xanthones including four new analogues were extracted and purified from the leaves of Garcinia xipshuanbannaensis. Multiple techniques including UV, 1D and 2D NMR, and HRESIMS were used to determine the structures of the isolated xanthones. These xanthones were evaluated for their cytotoxicity toward human cancer cells, and compound 4 exhibited activity against HeLa cells. A cytotoxic mechanism examination revealed the active compound induced cell apoptosis by arresting the cell cycle, increasing the levels of ROS, and inhibiting the expression of p-STAT3 in HeLa cells. In in vivo zebrafish experiments, compound 4 was found to block tumor proliferation and migration and have antiangiogenetic activity, and thus seems worthy of further laboratory evaluation.
AB - Eight prenylated xanthones including four new analogues were extracted and purified from the leaves of Garcinia xipshuanbannaensis. Multiple techniques including UV, 1D and 2D NMR, and HRESIMS were used to determine the structures of the isolated xanthones. These xanthones were evaluated for their cytotoxicity toward human cancer cells, and compound 4 exhibited activity against HeLa cells. A cytotoxic mechanism examination revealed the active compound induced cell apoptosis by arresting the cell cycle, increasing the levels of ROS, and inhibiting the expression of p-STAT3 in HeLa cells. In in vivo zebrafish experiments, compound 4 was found to block tumor proliferation and migration and have antiangiogenetic activity, and thus seems worthy of further laboratory evaluation.
UR - http://www.scopus.com/inward/record.url?scp=85106513738&partnerID=8YFLogxK
U2 - 10.1021/acs.jnatprod.0c01354
DO - 10.1021/acs.jnatprod.0c01354
M3 - Article
C2 - 33905250
AN - SCOPUS:85106513738
JO - Journal of Natural Products
JF - Journal of Natural Products
SN - 0163-3864
ER -
