Cytotoxic Drimane Sesquiterpenoids Isolated from Perenniporia maackiae

Jaeyoung Kwon; Hyaemin Lee; Young Hye Seo; Jieun Yun; Jun Lee; Hak Cheol Kwon; Yuanqiang Guo; Jong Soon Kang; Jae-Jin Kim; Dongho Lee

doi:10.1021/acs.jnatprod.8b00175

Cytotoxic Drimane Sesquiterpenoids Isolated from Perenniporia maackiae

Jaeyoung Kwon, Hyaemin Lee, Young Hye Seo, Jieun Yun, Jun Lee, Hak Cheol Kwon, Yuanqiang Guo, Jong Soon Kang, Jae-Jin Kim, Dongho Lee

Research output: Contribution to journal › Article

4 Citations (Scopus)

Abstract

A chemical investigation of a basidiomycetes fungus, Perenniporia maackiae, led to the discovery of 12 drimane sesquiterpenoids, including seven new constituents (1-7). The elucidation of the structures was performed via interpreting extensive spectroscopic methods, including ECD calculations. Among all isolated compounds, 1, 2, and 6 exhibited cytotoxicity toward six carcinoma cells, including ACHN, HCT-15, MDA-MB-231, NCI-H23, NUGC-3, and PC-3 cells, with half-maximal inhibition of cell proliferation values of 1.2-6.0 μM.

Original language	English
Pages (from-to)	1444-1450
Number of pages	7
Journal	Journal of Natural Products
Volume	81
Issue number	6
DOIs	https://doi.org/10.1021/acs.jnatprod.8b00175
Publication status	Published - 2018 Jun 22

Fingerprint

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

Cite this

Kwon, J., Lee, H., Seo, Y. H., Yun, J., Lee, J., Kwon, H. C., Guo, Y., Kang, J. S., Kim, J-J., & Lee, D. (2018). Cytotoxic Drimane Sesquiterpenoids Isolated from Perenniporia maackiae. Journal of Natural Products, 81(6), 1444-1450. https://doi.org/10.1021/acs.jnatprod.8b00175

@article{ad842455b0734ab69f49c078387d3329,

title = "Cytotoxic Drimane Sesquiterpenoids Isolated from Perenniporia maackiae",

abstract = "A chemical investigation of a basidiomycetes fungus, Perenniporia maackiae, led to the discovery of 12 drimane sesquiterpenoids, including seven new constituents (1-7). The elucidation of the structures was performed via interpreting extensive spectroscopic methods, including ECD calculations. Among all isolated compounds, 1, 2, and 6 exhibited cytotoxicity toward six carcinoma cells, including ACHN, HCT-15, MDA-MB-231, NCI-H23, NUGC-3, and PC-3 cells, with half-maximal inhibition of cell proliferation values of 1.2-6.0 μM.",

author = "Jaeyoung Kwon and Hyaemin Lee and Seo, {Young Hye} and Jieun Yun and Jun Lee and Kwon, {Hak Cheol} and Yuanqiang Guo and Kang, {Jong Soon} and Jae-Jin Kim and Dongho Lee",

year = "2018",

month = jun,

day = "22",

doi = "10.1021/acs.jnatprod.8b00175",

language = "English",

volume = "81",

pages = "1444--1450",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

number = "6",

}

TY - JOUR

T1 - Cytotoxic Drimane Sesquiterpenoids Isolated from Perenniporia maackiae

AU - Kwon, Jaeyoung

AU - Lee, Hyaemin

AU - Seo, Young Hye

AU - Yun, Jieun

AU - Lee, Jun

AU - Kwon, Hak Cheol

AU - Guo, Yuanqiang

AU - Kang, Jong Soon

AU - Kim, Jae-Jin

AU - Lee, Dongho

PY - 2018/6/22

Y1 - 2018/6/22

N2 - A chemical investigation of a basidiomycetes fungus, Perenniporia maackiae, led to the discovery of 12 drimane sesquiterpenoids, including seven new constituents (1-7). The elucidation of the structures was performed via interpreting extensive spectroscopic methods, including ECD calculations. Among all isolated compounds, 1, 2, and 6 exhibited cytotoxicity toward six carcinoma cells, including ACHN, HCT-15, MDA-MB-231, NCI-H23, NUGC-3, and PC-3 cells, with half-maximal inhibition of cell proliferation values of 1.2-6.0 μM.

AB - A chemical investigation of a basidiomycetes fungus, Perenniporia maackiae, led to the discovery of 12 drimane sesquiterpenoids, including seven new constituents (1-7). The elucidation of the structures was performed via interpreting extensive spectroscopic methods, including ECD calculations. Among all isolated compounds, 1, 2, and 6 exhibited cytotoxicity toward six carcinoma cells, including ACHN, HCT-15, MDA-MB-231, NCI-H23, NUGC-3, and PC-3 cells, with half-maximal inhibition of cell proliferation values of 1.2-6.0 μM.

UR - http://www.scopus.com/inward/record.url?scp=85049044873&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85049044873&partnerID=8YFLogxK

U2 - 10.1021/acs.jnatprod.8b00175

DO - 10.1021/acs.jnatprod.8b00175

M3 - Article

C2 - 29878761

AN - SCOPUS:85049044873

VL - 81

SP - 1444

EP - 1450

JO - Journal of Natural Products

JF - Journal of Natural Products

SN - 0163-3864

IS - 6

ER -

Access to Document

10.1021/acs.jnatprod.8b00175