TY - JOUR
T1 - Cytotoxic Drimane Sesquiterpenoids Isolated from Perenniporia maackiae
AU - Kwon, Jaeyoung
AU - Lee, Hyaemin
AU - Seo, Young Hye
AU - Yun, Jieun
AU - Lee, Jun
AU - Kwon, Hak Cheol
AU - Guo, Yuanqiang
AU - Kang, Jong Soon
AU - Kim, Jae Jin
AU - Lee, Dongho
N1 - Funding Information:
The research was financially supported by the Korea Institute of Science & Technology Program (2E27831 and 2Z05310), the KRIBB Research Initiative Program, Korea University, and the National Research Foundation of Korea (NRF-2015R1D1A1A01060321).
Publisher Copyright:
© 2018 American Chemical Society and American Society of Pharmacognosy.
PY - 2018/6/22
Y1 - 2018/6/22
N2 - A chemical investigation of a basidiomycetes fungus, Perenniporia maackiae, led to the discovery of 12 drimane sesquiterpenoids, including seven new constituents (1-7). The elucidation of the structures was performed via interpreting extensive spectroscopic methods, including ECD calculations. Among all isolated compounds, 1, 2, and 6 exhibited cytotoxicity toward six carcinoma cells, including ACHN, HCT-15, MDA-MB-231, NCI-H23, NUGC-3, and PC-3 cells, with half-maximal inhibition of cell proliferation values of 1.2-6.0 μM.
AB - A chemical investigation of a basidiomycetes fungus, Perenniporia maackiae, led to the discovery of 12 drimane sesquiterpenoids, including seven new constituents (1-7). The elucidation of the structures was performed via interpreting extensive spectroscopic methods, including ECD calculations. Among all isolated compounds, 1, 2, and 6 exhibited cytotoxicity toward six carcinoma cells, including ACHN, HCT-15, MDA-MB-231, NCI-H23, NUGC-3, and PC-3 cells, with half-maximal inhibition of cell proliferation values of 1.2-6.0 μM.
UR - http://www.scopus.com/inward/record.url?scp=85049044873&partnerID=8YFLogxK
U2 - 10.1021/acs.jnatprod.8b00175
DO - 10.1021/acs.jnatprod.8b00175
M3 - Article
C2 - 29878761
AN - SCOPUS:85049044873
VL - 81
SP - 1444
EP - 1450
JO - Journal of Natural Products
JF - Journal of Natural Products
SN - 0163-3864
IS - 6
ER -