Cytotoxic Drimane Sesquiterpenoids Isolated from Perenniporia maackiae

Jaeyoung Kwon, Hyaemin Lee, Young Hye Seo, Jieun Yun, Jun Lee, Hak Cheol Kwon, Yuanqiang Guo, Jong Soon Kang, Jae-Jin Kim, Dongho Lee

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A chemical investigation of a basidiomycetes fungus, Perenniporia maackiae, led to the discovery of 12 drimane sesquiterpenoids, including seven new constituents (1-7). The elucidation of the structures was performed via interpreting extensive spectroscopic methods, including ECD calculations. Among all isolated compounds, 1, 2, and 6 exhibited cytotoxicity toward six carcinoma cells, including ACHN, HCT-15, MDA-MB-231, NCI-H23, NUGC-3, and PC-3 cells, with half-maximal inhibition of cell proliferation values of 1.2-6.0 μM.

Original languageEnglish
Pages (from-to)1444-1450
Number of pages7
JournalJournal of Natural Products
Volume81
Issue number6
DOIs
Publication statusPublished - 2018 Jun 22

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Cell proliferation
Cytotoxicity
Fungi
Cells
Basidiomycota
Cell Proliferation
Carcinoma
drimane

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Cite this

Cytotoxic Drimane Sesquiterpenoids Isolated from Perenniporia maackiae. / Kwon, Jaeyoung; Lee, Hyaemin; Seo, Young Hye; Yun, Jieun; Lee, Jun; Kwon, Hak Cheol; Guo, Yuanqiang; Kang, Jong Soon; Kim, Jae-Jin; Lee, Dongho.

In: Journal of Natural Products, Vol. 81, No. 6, 22.06.2018, p. 1444-1450.

Research output: Contribution to journalArticle

Kwon, J, Lee, H, Seo, YH, Yun, J, Lee, J, Kwon, HC, Guo, Y, Kang, JS, Kim, J-J & Lee, D 2018, 'Cytotoxic Drimane Sesquiterpenoids Isolated from Perenniporia maackiae', Journal of Natural Products, vol. 81, no. 6, pp. 1444-1450. https://doi.org/10.1021/acs.jnatprod.8b00175
Kwon, Jaeyoung ; Lee, Hyaemin ; Seo, Young Hye ; Yun, Jieun ; Lee, Jun ; Kwon, Hak Cheol ; Guo, Yuanqiang ; Kang, Jong Soon ; Kim, Jae-Jin ; Lee, Dongho. / Cytotoxic Drimane Sesquiterpenoids Isolated from Perenniporia maackiae. In: Journal of Natural Products. 2018 ; Vol. 81, No. 6. pp. 1444-1450.
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