Abstract
A chemical investigation of a basidiomycetes fungus, Perenniporia maackiae, led to the discovery of 12 drimane sesquiterpenoids, including seven new constituents (1-7). The elucidation of the structures was performed via interpreting extensive spectroscopic methods, including ECD calculations. Among all isolated compounds, 1, 2, and 6 exhibited cytotoxicity toward six carcinoma cells, including ACHN, HCT-15, MDA-MB-231, NCI-H23, NUGC-3, and PC-3 cells, with half-maximal inhibition of cell proliferation values of 1.2-6.0 μM.
| Original language | English |
|---|---|
| Pages (from-to) | 1444-1450 |
| Number of pages | 7 |
| Journal | Journal of Natural Products |
| Volume | 81 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2018 Jun 22 |
ASJC Scopus subject areas
- Analytical Chemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry
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Cite this
Kwon, J., Lee, H., Seo, Y. H., Yun, J., Lee, J., Kwon, H. C., Guo, Y., Kang, J. S., Kim, J-J., & Lee, D. (2018). Cytotoxic Drimane Sesquiterpenoids Isolated from Perenniporia maackiae. Journal of Natural Products, 81(6), 1444-1450. https://doi.org/10.1021/acs.jnatprod.8b00175