Abstract
A chemical investigation of a basidiomycetes fungus, Perenniporia maackiae, led to the discovery of 12 drimane sesquiterpenoids, including seven new constituents (1-7). The elucidation of the structures was performed via interpreting extensive spectroscopic methods, including ECD calculations. Among all isolated compounds, 1, 2, and 6 exhibited cytotoxicity toward six carcinoma cells, including ACHN, HCT-15, MDA-MB-231, NCI-H23, NUGC-3, and PC-3 cells, with half-maximal inhibition of cell proliferation values of 1.2-6.0 μM.
| Original language | English |
|---|---|
| Pages (from-to) | 1444-1450 |
| Number of pages | 7 |
| Journal | Journal of Natural Products |
| Volume | 81 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2018 Jun 22 |
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ASJC Scopus subject areas
- Analytical Chemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry
Cite this
Cytotoxic Drimane Sesquiterpenoids Isolated from Perenniporia maackiae. / Kwon, Jaeyoung; Lee, Hyaemin; Seo, Young Hye; Yun, Jieun; Lee, Jun; Kwon, Hak Cheol; Guo, Yuanqiang; Kang, Jong Soon; Kim, Jae-Jin; Lee, Dongho.
In: Journal of Natural Products, Vol. 81, No. 6, 22.06.2018, p. 1444-1450.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cytotoxic Drimane Sesquiterpenoids Isolated from Perenniporia maackiae
AU - Kwon, Jaeyoung
AU - Lee, Hyaemin
AU - Seo, Young Hye
AU - Yun, Jieun
AU - Lee, Jun
AU - Kwon, Hak Cheol
AU - Guo, Yuanqiang
AU - Kang, Jong Soon
AU - Kim, Jae-Jin
AU - Lee, Dongho
PY - 2018/6/22
Y1 - 2018/6/22
N2 - A chemical investigation of a basidiomycetes fungus, Perenniporia maackiae, led to the discovery of 12 drimane sesquiterpenoids, including seven new constituents (1-7). The elucidation of the structures was performed via interpreting extensive spectroscopic methods, including ECD calculations. Among all isolated compounds, 1, 2, and 6 exhibited cytotoxicity toward six carcinoma cells, including ACHN, HCT-15, MDA-MB-231, NCI-H23, NUGC-3, and PC-3 cells, with half-maximal inhibition of cell proliferation values of 1.2-6.0 μM.
AB - A chemical investigation of a basidiomycetes fungus, Perenniporia maackiae, led to the discovery of 12 drimane sesquiterpenoids, including seven new constituents (1-7). The elucidation of the structures was performed via interpreting extensive spectroscopic methods, including ECD calculations. Among all isolated compounds, 1, 2, and 6 exhibited cytotoxicity toward six carcinoma cells, including ACHN, HCT-15, MDA-MB-231, NCI-H23, NUGC-3, and PC-3 cells, with half-maximal inhibition of cell proliferation values of 1.2-6.0 μM.
UR - http://www.scopus.com/inward/record.url?scp=85049044873&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85049044873&partnerID=8YFLogxK
U2 - 10.1021/acs.jnatprod.8b00175
DO - 10.1021/acs.jnatprod.8b00175
M3 - Article
C2 - 29878761
AN - SCOPUS:85049044873
VL - 81
SP - 1444
EP - 1450
JO - Journal of Natural Products
JF - Journal of Natural Products
SN - 0163-3864
IS - 6
ER -