Cytotoxic Drimane Sesquiterpenoids Isolated from Perenniporia maackiae

Jaeyoung Kwon, Hyaemin Lee, Young Hye Seo, Jieun Yun, Jun Lee, Hak Cheol Kwon, Yuanqiang Guo, Jong Soon Kang, Jae Jin Kim, Dongho Lee

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

A chemical investigation of a basidiomycetes fungus, Perenniporia maackiae, led to the discovery of 12 drimane sesquiterpenoids, including seven new constituents (1-7). The elucidation of the structures was performed via interpreting extensive spectroscopic methods, including ECD calculations. Among all isolated compounds, 1, 2, and 6 exhibited cytotoxicity toward six carcinoma cells, including ACHN, HCT-15, MDA-MB-231, NCI-H23, NUGC-3, and PC-3 cells, with half-maximal inhibition of cell proliferation values of 1.2-6.0 μM.

Original languageEnglish
Pages (from-to)1444-1450
Number of pages7
JournalJournal of Natural Products
Volume81
Issue number6
DOIs
Publication statusPublished - 2018 Jun 22

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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