Dairy Propionibacterium extends the mean lifespan of Caenorhabditis elegans via activation of the innate immune system

Gayeung Kwon, Jiyun Lee, Young Hee Lim

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Dairy Propionibacterium freudenreichii is a candidate non-lactic acid probiotic. However, little information is available on the effect of P. freudenreichii on lifespan extension in humans. The aim of this study was to evaluate the effects of P. freudenreichii on lifespan extension and to elucidate the mechanism of P. freudenreichii-dependent lifespan extension in Caenorhabditis elegans. The results showed that P. freudenreichii significantly (p < 0.05) extended the lifespan of C. elegans compared with Escherichia coli OP50, a standard food for the worm. Analysis of age-related biomarkers showed that P. freudenreichii retards ageing. Moreover, P. freudenreichii increased resistance against a human pathogen, Salmonella typhimurium, through the activation of skn-1, which is involved in pathogen resistance in C. elegans. Furthermore, P. freudenreichii-fed daf-16, jnk-1, skn-1 or daf-7 loss-of-function mutants showed an extended mean lifespan compared with E. coli OP50-fed worms. However, the increase in lifespan was not observed in pmk-1, sek-1, mek-1, dbl-1, daf-12 or daf-2 mutants, which suggests potential roles for these genes in P. freudenreichii-induced longevity in C. elegans. In conclusion, P. freudenreichii extends the lifespan of C. elegans via the p38 MAPK pathway involved in stress response and the TGF-β pathways associated with anti-inflammation processes in the immune system.

Original languageEnglish
Article number31713
JournalScientific Reports
Volume6
DOIs
Publication statusPublished - 2016 Aug 17

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Dairy Propionibacterium extends the mean lifespan of Caenorhabditis elegans via activation of the innate immune system'. Together they form a unique fingerprint.

  • Cite this