DAOA variants on diagnosis and response to treatment in patients with major depressive disorder and bipolar disorder

A. Chiesa, Chi Un Pae, S. Porcelli, C. Han, S. J. Lee, A. A. Patkar, M. H. Park, T. Y. Jun, A. Serretti

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective: This study investigated whether selected D-amino acid oxidase activator (DAOA) gene single nucleotide polymorphisms (SNPs; rs3916966, rs3916967, rs2391191, rs3916968, rs7139958, rs9558571, rs778293) are associated with major depressive disorder (MDD) and bipolar disorder (BD), and whether they can predict clinical outcomes in Korean in-patients treated with antidepressants and mood stabilizers, respectively. Methods: In total, 145 patients with MDD, 132 patients with BD and 170 psychiatrically healthy controls were genotyped for the DAOA SNPs. Baseline and final clinical assessments included the Montgomery- Asberg Depression Rating Scale and Young Mania Rating Scale for patients with MDD and BD, respectively. Results: There was no association between DAOA SNP genotypes or alleles with diagnosis, clinical improvement, response rates or remission rates for MDD and BD. Haplotype analyses found no association with MDD or BD diagnosis or clinical outcomes. Conclusion: The findings suggest that the DAOA SNPs investigated may not affect MDD or BD phenotype, clinical symptoms or other clinical factors, and are unlikely to be involved in MDD or BD development and treatment outcomes. Given the study's limitations, further investigation should be carried out.

Original languageEnglish
Pages (from-to)258-265
Number of pages8
JournalJournal of International Medical Research
Volume40
Issue number1
DOIs
Publication statusPublished - 2012

Keywords

  • Bipolar disorder
  • Clinical improvement
  • D-amino acid oxidase activator (DAOA)
  • Major depressive disorder
  • Treatment response

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Biochemistry, medical

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