Day/night difference in extradural cortical stimulation for motor relearning in a subacute stroke rat model

Joo Yeon Kim, Woong Sun, Eunhee Park, Jiyeong Lee, Hyun Kim, Yong Il Shin, Yun Hee Kim, Won Hyuk Chang

Research output: Contribution to journalArticle

Abstract

Purpose: The aim of this study was to assess the proper timing of extradural cortical stimulation (ECS) on the motor relearning in a rat model of subacute photothrombotic stroke. Methods: Photothrombotic infarction was induced on the dominant sensorimotor cortex in male Sprague-Dawley rats after training in a single-pellet reaching task (SPRT). Rats were randomly divided into three groups after stroke: ECS during the inactive period (Day-ECS group), ECS during the active period (Night-ECS group) and no ECS (Non-stimulated group). Six sham-operated rats were assigned to the control group. The Day- and Night-ECS group received continuous ECS for 12 hours during the day or night for 2 weeks from day 4 after the stroke. Behavioral assessment with SPRT was performed daily. Results: SPRT showed a significantly faster and greater improvement in the Day and Night-ECS groups than in the Non-stimulated group. In the Day- and Night-ECS groups, the success rate of SPRT differed significantly from Non-stimulated group on day 11 and day 8, respectively. In addition, the Night-ECS group showed a significantly higher SPRT success rate than the Day-ECS group from days 10 to 13. Conclusion: ECS during the active period might be more effective for motor relearning in the subacute stroke rat model.

Original languageEnglish
Pages (from-to)379-387
Number of pages9
JournalRestorative Neurology and Neuroscience
Volume34
Issue number3
DOIs
Publication statusPublished - 2016 Jun 14

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Stroke
Infarction
Sprague Dawley Rats
Control Groups

Keywords

  • Day/night
  • electrical stimulation
  • extradural cortical stimulation
  • motor learning
  • motor recovery
  • stroke

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience
  • Clinical Neurology

Cite this

Day/night difference in extradural cortical stimulation for motor relearning in a subacute stroke rat model. / Kim, Joo Yeon; Sun, Woong; Park, Eunhee; Lee, Jiyeong; Kim, Hyun; Shin, Yong Il; Kim, Yun Hee; Chang, Won Hyuk.

In: Restorative Neurology and Neuroscience, Vol. 34, No. 3, 14.06.2016, p. 379-387.

Research output: Contribution to journalArticle

Kim, Joo Yeon ; Sun, Woong ; Park, Eunhee ; Lee, Jiyeong ; Kim, Hyun ; Shin, Yong Il ; Kim, Yun Hee ; Chang, Won Hyuk. / Day/night difference in extradural cortical stimulation for motor relearning in a subacute stroke rat model. In: Restorative Neurology and Neuroscience. 2016 ; Vol. 34, No. 3. pp. 379-387.
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