Decrease in plasma adiponectin concentrations in patients with variant angina pectoris

Soon Jun Hong, Hong Seog Seo, Seung-Woon Rha, Joo Oh Dong, Ah Kwon Jung, No Lee Kap, Soo Jang Yang, Moo Ro Young, Chang Gyu Park

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background: Plasma adiponectin is decreased in patients with coronary artery diseases, especially in patients with acute coronary syndrome (ACS). However, the correlation between plasma adiponectin and variant angina pectoris (VAP) has not been verified. Plasma adiponectin concentrations between VAP and other coronary artery diseases was compared in the present study. The association between plasma adiponectin concentration and VAP was also investigated. Methods and Results: Plasma adiponectin concentrations in the VAP group (n=101) were compared with those of the ACS group (n=117), the stable angina pectoris group (n=108), and the normal coronary group (n=81). Plasma adiponectin concentrations in VAP and ACS were significantly lower than that of the normal coronary group (6.6±5.4 vs 5.2±4.0 vs 9.0±6.2 μg/ml, p<0.001, respectively). Multivariate analysis indicated that plasma adiponectin (odds ratio (OR) 0.735, 95% confidence interval (CI) 0.621-0.855, p=0.011), smoking (OR 2.012, 95% CI 1.210-3.880, p=0.020), and age (OR 0.976, 95% CI 0.957-0.997, p=0.022) correlated independently with the development of VAP. Conclusions: Our results suggest that a decrease in plasma adiponectin concentration might be associated with the development of VAP.

Original languageEnglish
Pages (from-to)414-418
Number of pages5
JournalCirculation Journal
Volume70
Issue number4
DOIs
Publication statusPublished - 2006 Apr 4

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Variant Angina Pectoris
Adiponectin
Acute Coronary Syndrome
Odds Ratio
Confidence Intervals
Coronary Artery Disease
Stable Angina
Multivariate Analysis
Smoking

Keywords

  • Acetylcholine
  • Acute coronary syndrome
  • Adiponectin
  • Variant angina

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology

Cite this

Decrease in plasma adiponectin concentrations in patients with variant angina pectoris. / Hong, Soon Jun; Seo, Hong Seog; Rha, Seung-Woon; Dong, Joo Oh; Jung, Ah Kwon; Kap, No Lee; Yang, Soo Jang; Young, Moo Ro; Park, Chang Gyu.

In: Circulation Journal, Vol. 70, No. 4, 04.04.2006, p. 414-418.

Research output: Contribution to journalArticle

Hong, Soon Jun ; Seo, Hong Seog ; Rha, Seung-Woon ; Dong, Joo Oh ; Jung, Ah Kwon ; Kap, No Lee ; Yang, Soo Jang ; Young, Moo Ro ; Park, Chang Gyu. / Decrease in plasma adiponectin concentrations in patients with variant angina pectoris. In: Circulation Journal. 2006 ; Vol. 70, No. 4. pp. 414-418.
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abstract = "Background: Plasma adiponectin is decreased in patients with coronary artery diseases, especially in patients with acute coronary syndrome (ACS). However, the correlation between plasma adiponectin and variant angina pectoris (VAP) has not been verified. Plasma adiponectin concentrations between VAP and other coronary artery diseases was compared in the present study. The association between plasma adiponectin concentration and VAP was also investigated. Methods and Results: Plasma adiponectin concentrations in the VAP group (n=101) were compared with those of the ACS group (n=117), the stable angina pectoris group (n=108), and the normal coronary group (n=81). Plasma adiponectin concentrations in VAP and ACS were significantly lower than that of the normal coronary group (6.6±5.4 vs 5.2±4.0 vs 9.0±6.2 μg/ml, p<0.001, respectively). Multivariate analysis indicated that plasma adiponectin (odds ratio (OR) 0.735, 95{\%} confidence interval (CI) 0.621-0.855, p=0.011), smoking (OR 2.012, 95{\%} CI 1.210-3.880, p=0.020), and age (OR 0.976, 95{\%} CI 0.957-0.997, p=0.022) correlated independently with the development of VAP. Conclusions: Our results suggest that a decrease in plasma adiponectin concentration might be associated with the development of VAP.",
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AU - Jung, Ah Kwon

AU - Kap, No Lee

AU - Yang, Soo Jang

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N2 - Background: Plasma adiponectin is decreased in patients with coronary artery diseases, especially in patients with acute coronary syndrome (ACS). However, the correlation between plasma adiponectin and variant angina pectoris (VAP) has not been verified. Plasma adiponectin concentrations between VAP and other coronary artery diseases was compared in the present study. The association between plasma adiponectin concentration and VAP was also investigated. Methods and Results: Plasma adiponectin concentrations in the VAP group (n=101) were compared with those of the ACS group (n=117), the stable angina pectoris group (n=108), and the normal coronary group (n=81). Plasma adiponectin concentrations in VAP and ACS were significantly lower than that of the normal coronary group (6.6±5.4 vs 5.2±4.0 vs 9.0±6.2 μg/ml, p<0.001, respectively). Multivariate analysis indicated that plasma adiponectin (odds ratio (OR) 0.735, 95% confidence interval (CI) 0.621-0.855, p=0.011), smoking (OR 2.012, 95% CI 1.210-3.880, p=0.020), and age (OR 0.976, 95% CI 0.957-0.997, p=0.022) correlated independently with the development of VAP. Conclusions: Our results suggest that a decrease in plasma adiponectin concentration might be associated with the development of VAP.

AB - Background: Plasma adiponectin is decreased in patients with coronary artery diseases, especially in patients with acute coronary syndrome (ACS). However, the correlation between plasma adiponectin and variant angina pectoris (VAP) has not been verified. Plasma adiponectin concentrations between VAP and other coronary artery diseases was compared in the present study. The association between plasma adiponectin concentration and VAP was also investigated. Methods and Results: Plasma adiponectin concentrations in the VAP group (n=101) were compared with those of the ACS group (n=117), the stable angina pectoris group (n=108), and the normal coronary group (n=81). Plasma adiponectin concentrations in VAP and ACS were significantly lower than that of the normal coronary group (6.6±5.4 vs 5.2±4.0 vs 9.0±6.2 μg/ml, p<0.001, respectively). Multivariate analysis indicated that plasma adiponectin (odds ratio (OR) 0.735, 95% confidence interval (CI) 0.621-0.855, p=0.011), smoking (OR 2.012, 95% CI 1.210-3.880, p=0.020), and age (OR 0.976, 95% CI 0.957-0.997, p=0.022) correlated independently with the development of VAP. Conclusions: Our results suggest that a decrease in plasma adiponectin concentration might be associated with the development of VAP.

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