Decrease in plasma adiponectin concentrations in patients with vasospastic angina

Soon Jun Hong, Chang Gyu Park, Hong Seog Seo, Seung-Woon Rha, Jin Won Kim, Dong Joo Oh, Jung Ah Kwon, Kap No Lee, Yang Soo Jang, Young Moo Ro

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background and Objectives: Plasma adiponectin, which decreases the progression of atherosclerosis and insulin resistance, as well as suppressing lipid accumulation in macrophages, is decreased in patients with acute myocardial infarction and unstable angina pectoris; however, the correlation between plasma adiponectin and vasospastic angina pectoris (VAP) remains to be verified. We compared the plasma adiponectin concentration between patients with VAP and other coronary artery diseases; moreover, we investigated the association between the plasma adiponectin concentration and VAP. Subjects and Methods: Following coronary angiography for the evaluation of chest pain, 395 subjects (180 women and 215 men) were divided into 4 groups: acute coronary syndrome (ACS)(n=117), VAP (n=94), stable angina pectoris (SAP)(n=108) and angiographically normal coronary artery (n=76). The acetylcholine provocation test was used to confirm VAP, and plasma adiponectin concentrations were measured in all participants. Results: The plasma adiponectin concentrations in patients with VAP and ACS were significantly lower than that of the normal coronary artery group (6.6 ± 5.4 vs. 5.2 ± 4.0 vs. 9.0 ± 6.2 μg/mL, p<0.001, respectively). A multivariate analysis indicated that plasma adiponectin [odd ratio (OR) 0.744, 95% confidence interval (CI) 0.645 to 0.858, p=0.001], smoking (OR 2.054, 95% CI 1.027 to 4.106, p=0.042) and age (OR 0.966, 95% CI 0.935 to 0.997, p=0.031) were independently correlated in patients diagnosed with VAP. Conclusion: Our results suggest that a decreased plasma adiponectin concentration may be associated with VAP.

Original languageEnglish
Pages (from-to)255-260
Number of pages6
JournalKorean Circulation Journal
Volume36
Issue number4
Publication statusPublished - 2006 Apr 1

Keywords

  • Acetylcholine
  • Adiponectin
  • Coronary artery vasospasm

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Internal Medicine

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