Decrease in plasma adiponectin concentrations in patients with vasospastic angina

Soon Jun Hong, Chang Gyu Park, Hong Seog Seo, Seung-Woon Rha, Jin Won Kim, Dong Joo Oh, Jung Ah Kwon, Kap No Lee, Yang Soo Jang, Young Moo Ro

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background and Objectives: Plasma adiponectin, which decreases the progression of atherosclerosis and insulin resistance, as well as suppressing lipid accumulation in macrophages, is decreased in patients with acute myocardial infarction and unstable angina pectoris; however, the correlation between plasma adiponectin and vasospastic angina pectoris (VAP) remains to be verified. We compared the plasma adiponectin concentration between patients with VAP and other coronary artery diseases; moreover, we investigated the association between the plasma adiponectin concentration and VAP. Subjects and Methods: Following coronary angiography for the evaluation of chest pain, 395 subjects (180 women and 215 men) were divided into 4 groups: acute coronary syndrome (ACS)(n=117), VAP (n=94), stable angina pectoris (SAP)(n=108) and angiographically normal coronary artery (n=76). The acetylcholine provocation test was used to confirm VAP, and plasma adiponectin concentrations were measured in all participants. Results: The plasma adiponectin concentrations in patients with VAP and ACS were significantly lower than that of the normal coronary artery group (6.6 ± 5.4 vs. 5.2 ± 4.0 vs. 9.0 ± 6.2 μg/mL, p<0.001, respectively). A multivariate analysis indicated that plasma adiponectin [odd ratio (OR) 0.744, 95% confidence interval (CI) 0.645 to 0.858, p=0.001], smoking (OR 2.054, 95% CI 1.027 to 4.106, p=0.042) and age (OR 0.966, 95% CI 0.935 to 0.997, p=0.031) were independently correlated in patients diagnosed with VAP. Conclusion: Our results suggest that a decreased plasma adiponectin concentration may be associated with VAP.

Original languageEnglish
Pages (from-to)255-260
Number of pages6
JournalKorean Circulation Journal
Volume36
Issue number4
Publication statusPublished - 2006 Apr 1

Fingerprint

Adiponectin
Angina Pectoris
Odds Ratio
Confidence Intervals
Acute Coronary Syndrome
Coronary Vessels
Stable Angina
Unstable Angina
Coronary Angiography
Chest Pain
Acetylcholine
Insulin Resistance
Coronary Artery Disease
Atherosclerosis
Multivariate Analysis
Smoking
Macrophages
Myocardial Infarction
Lipids

Keywords

  • Acetylcholine
  • Adiponectin
  • Coronary artery vasospasm

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Internal Medicine

Cite this

Decrease in plasma adiponectin concentrations in patients with vasospastic angina. / Hong, Soon Jun; Park, Chang Gyu; Seo, Hong Seog; Rha, Seung-Woon; Kim, Jin Won; Oh, Dong Joo; Kwon, Jung Ah; Lee, Kap No; Jang, Yang Soo; Ro, Young Moo.

In: Korean Circulation Journal, Vol. 36, No. 4, 01.04.2006, p. 255-260.

Research output: Contribution to journalArticle

@article{676d29dab490470baa7627fd32799fe1,
title = "Decrease in plasma adiponectin concentrations in patients with vasospastic angina",
abstract = "Background and Objectives: Plasma adiponectin, which decreases the progression of atherosclerosis and insulin resistance, as well as suppressing lipid accumulation in macrophages, is decreased in patients with acute myocardial infarction and unstable angina pectoris; however, the correlation between plasma adiponectin and vasospastic angina pectoris (VAP) remains to be verified. We compared the plasma adiponectin concentration between patients with VAP and other coronary artery diseases; moreover, we investigated the association between the plasma adiponectin concentration and VAP. Subjects and Methods: Following coronary angiography for the evaluation of chest pain, 395 subjects (180 women and 215 men) were divided into 4 groups: acute coronary syndrome (ACS)(n=117), VAP (n=94), stable angina pectoris (SAP)(n=108) and angiographically normal coronary artery (n=76). The acetylcholine provocation test was used to confirm VAP, and plasma adiponectin concentrations were measured in all participants. Results: The plasma adiponectin concentrations in patients with VAP and ACS were significantly lower than that of the normal coronary artery group (6.6 ± 5.4 vs. 5.2 ± 4.0 vs. 9.0 ± 6.2 μg/mL, p<0.001, respectively). A multivariate analysis indicated that plasma adiponectin [odd ratio (OR) 0.744, 95{\%} confidence interval (CI) 0.645 to 0.858, p=0.001], smoking (OR 2.054, 95{\%} CI 1.027 to 4.106, p=0.042) and age (OR 0.966, 95{\%} CI 0.935 to 0.997, p=0.031) were independently correlated in patients diagnosed with VAP. Conclusion: Our results suggest that a decreased plasma adiponectin concentration may be associated with VAP.",
keywords = "Acetylcholine, Adiponectin, Coronary artery vasospasm",
author = "Hong, {Soon Jun} and Park, {Chang Gyu} and Seo, {Hong Seog} and Seung-Woon Rha and Kim, {Jin Won} and Oh, {Dong Joo} and Kwon, {Jung Ah} and Lee, {Kap No} and Jang, {Yang Soo} and Ro, {Young Moo}",
year = "2006",
month = "4",
day = "1",
language = "English",
volume = "36",
pages = "255--260",
journal = "Korean Circulation Journal",
issn = "1738-5520",
publisher = "Korean Society of Circulation",
number = "4",

}

TY - JOUR

T1 - Decrease in plasma adiponectin concentrations in patients with vasospastic angina

AU - Hong, Soon Jun

AU - Park, Chang Gyu

AU - Seo, Hong Seog

AU - Rha, Seung-Woon

AU - Kim, Jin Won

AU - Oh, Dong Joo

AU - Kwon, Jung Ah

AU - Lee, Kap No

AU - Jang, Yang Soo

AU - Ro, Young Moo

PY - 2006/4/1

Y1 - 2006/4/1

N2 - Background and Objectives: Plasma adiponectin, which decreases the progression of atherosclerosis and insulin resistance, as well as suppressing lipid accumulation in macrophages, is decreased in patients with acute myocardial infarction and unstable angina pectoris; however, the correlation between plasma adiponectin and vasospastic angina pectoris (VAP) remains to be verified. We compared the plasma adiponectin concentration between patients with VAP and other coronary artery diseases; moreover, we investigated the association between the plasma adiponectin concentration and VAP. Subjects and Methods: Following coronary angiography for the evaluation of chest pain, 395 subjects (180 women and 215 men) were divided into 4 groups: acute coronary syndrome (ACS)(n=117), VAP (n=94), stable angina pectoris (SAP)(n=108) and angiographically normal coronary artery (n=76). The acetylcholine provocation test was used to confirm VAP, and plasma adiponectin concentrations were measured in all participants. Results: The plasma adiponectin concentrations in patients with VAP and ACS were significantly lower than that of the normal coronary artery group (6.6 ± 5.4 vs. 5.2 ± 4.0 vs. 9.0 ± 6.2 μg/mL, p<0.001, respectively). A multivariate analysis indicated that plasma adiponectin [odd ratio (OR) 0.744, 95% confidence interval (CI) 0.645 to 0.858, p=0.001], smoking (OR 2.054, 95% CI 1.027 to 4.106, p=0.042) and age (OR 0.966, 95% CI 0.935 to 0.997, p=0.031) were independently correlated in patients diagnosed with VAP. Conclusion: Our results suggest that a decreased plasma adiponectin concentration may be associated with VAP.

AB - Background and Objectives: Plasma adiponectin, which decreases the progression of atherosclerosis and insulin resistance, as well as suppressing lipid accumulation in macrophages, is decreased in patients with acute myocardial infarction and unstable angina pectoris; however, the correlation between plasma adiponectin and vasospastic angina pectoris (VAP) remains to be verified. We compared the plasma adiponectin concentration between patients with VAP and other coronary artery diseases; moreover, we investigated the association between the plasma adiponectin concentration and VAP. Subjects and Methods: Following coronary angiography for the evaluation of chest pain, 395 subjects (180 women and 215 men) were divided into 4 groups: acute coronary syndrome (ACS)(n=117), VAP (n=94), stable angina pectoris (SAP)(n=108) and angiographically normal coronary artery (n=76). The acetylcholine provocation test was used to confirm VAP, and plasma adiponectin concentrations were measured in all participants. Results: The plasma adiponectin concentrations in patients with VAP and ACS were significantly lower than that of the normal coronary artery group (6.6 ± 5.4 vs. 5.2 ± 4.0 vs. 9.0 ± 6.2 μg/mL, p<0.001, respectively). A multivariate analysis indicated that plasma adiponectin [odd ratio (OR) 0.744, 95% confidence interval (CI) 0.645 to 0.858, p=0.001], smoking (OR 2.054, 95% CI 1.027 to 4.106, p=0.042) and age (OR 0.966, 95% CI 0.935 to 0.997, p=0.031) were independently correlated in patients diagnosed with VAP. Conclusion: Our results suggest that a decreased plasma adiponectin concentration may be associated with VAP.

KW - Acetylcholine

KW - Adiponectin

KW - Coronary artery vasospasm

UR - http://www.scopus.com/inward/record.url?scp=33646486621&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33646486621&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:33646486621

VL - 36

SP - 255

EP - 260

JO - Korean Circulation Journal

JF - Korean Circulation Journal

SN - 1738-5520

IS - 4

ER -