Decrease in the kainate-induced wet dog shake behavior in genetically epilepsy-prone rats: Possible involvement of an impaired synaptic transmission to the 5-HT2A receptor

Eun Joo Shin, Hoon Jeong Ji, Hee Chung Yoon, Tae Woo Kim, Young Shin Chan, Won Ki Kim, Kwang Ho Ko, Hyoung Chun Kim

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Genetically epilepsy-prone rats (GEPR-9s) were derived from Sprague-Dawley rats (SD). The number of kainate-induced wet dog shake behavior (WDS) responses was found to decrease significantly in GEPR-9s compared to SD. WDS responses were potentiated by 5-hydroxytryptophan or 2,5-dimethoxy-4-iodoamphetamine and antagonized by ritanserin. The antagonizing effect of ritanserin on WDS latency was more evident in GEPR-9s than in SD, and hippocampal expression of activity-regulated cytoskeleton-associated protein paralleled the severity of WDS. The results suggest that downstream serotonergic synaptic activation is less pronounced in GEPR-9s than in SD and that the serotonergic agent may directly activate postsynaptic 5-HT2A receptors in both strains.

Original languageEnglish
Pages (from-to)401-404
Number of pages4
JournalJournal of Pharmacological Sciences
Volume110
Issue number3
DOIs
Publication statusPublished - 2009

Keywords

  • Genetically epilepsy-prone rat
  • Kainic acid
  • Wet dog shake

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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