Decrease in the kainate-induced wet dog shake behavior in genetically epilepsy-prone rats

Possible involvement of an impaired synaptic transmission to the 5-HT2A receptor

Eun Joo Shin, Hoon Jeong Ji, Hee Chung Yoon, Tae Woo Kim, Young Shin Chan, Won-Ki Kim, Kwang Ho Ko, Hyoung Chun Kim

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Genetically epilepsy-prone rats (GEPR-9s) were derived from Sprague-Dawley rats (SD). The number of kainate-induced wet dog shake behavior (WDS) responses was found to decrease significantly in GEPR-9s compared to SD. WDS responses were potentiated by 5-hydroxytryptophan or 2,5-dimethoxy-4-iodoamphetamine and antagonized by ritanserin. The antagonizing effect of ritanserin on WDS latency was more evident in GEPR-9s than in SD, and hippocampal expression of activity-regulated cytoskeleton-associated protein paralleled the severity of WDS. The results suggest that downstream serotonergic synaptic activation is less pronounced in GEPR-9s than in SD and that the serotonergic agent may directly activate postsynaptic 5-HT2A receptors in both strains.

Original languageEnglish
Pages (from-to)401-404
Number of pages4
JournalJournal of Pharmacological Sciences
Volume110
Issue number3
DOIs
Publication statusPublished - 2009 Aug 3

Fingerprint

Receptor, Serotonin, 5-HT2A
Kainic Acid
Synaptic Transmission
Sprague Dawley Rats
Epilepsy
Ritanserin
Dogs
Serotonin Agents
5-Hydroxytryptophan
Cytoskeleton
Proteins

Keywords

  • Genetically epilepsy-prone rat
  • Kainic acid
  • Wet dog shake

ASJC Scopus subject areas

  • Pharmacology
  • Molecular Medicine

Cite this

Decrease in the kainate-induced wet dog shake behavior in genetically epilepsy-prone rats : Possible involvement of an impaired synaptic transmission to the 5-HT2A receptor. / Shin, Eun Joo; Ji, Hoon Jeong; Yoon, Hee Chung; Kim, Tae Woo; Chan, Young Shin; Kim, Won-Ki; Ko, Kwang Ho; Kim, Hyoung Chun.

In: Journal of Pharmacological Sciences, Vol. 110, No. 3, 03.08.2009, p. 401-404.

Research output: Contribution to journalArticle

Shin, Eun Joo ; Ji, Hoon Jeong ; Yoon, Hee Chung ; Kim, Tae Woo ; Chan, Young Shin ; Kim, Won-Ki ; Ko, Kwang Ho ; Kim, Hyoung Chun. / Decrease in the kainate-induced wet dog shake behavior in genetically epilepsy-prone rats : Possible involvement of an impaired synaptic transmission to the 5-HT2A receptor. In: Journal of Pharmacological Sciences. 2009 ; Vol. 110, No. 3. pp. 401-404.
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