Decrease in the kainate-induced wet dog shake behavior in genetically epilepsy-prone rats: Possible involvement of an impaired synaptic transmission to the 5-HT2A receptor

Eun Joo Shin; Hoon Jeong Ji; Hee Chung Yoon; Tae Woo Kim; Young Shin Chan; Won Ki Kim; Kwang Ho Ko; Hyoung Chun Kim

doi:10.1254/jphs.09015SC

Decrease in the kainate-induced wet dog shake behavior in genetically epilepsy-prone rats: Possible involvement of an impaired synaptic transmission to the 5-HT_2A receptor

Eun Joo Shin, Hoon Jeong Ji, Hee Chung Yoon, Tae Woo Kim, Young Shin Chan, Won Ki Kim, Kwang Ho Ko, Hyoung Chun Kim

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Genetically epilepsy-prone rats (GEPR-9s) were derived from Sprague-Dawley rats (SD). The number of kainate-induced wet dog shake behavior (WDS) responses was found to decrease significantly in GEPR-9s compared to SD. WDS responses were potentiated by 5-hydroxytryptophan or 2,5-dimethoxy-4-iodoamphetamine and antagonized by ritanserin. The antagonizing effect of ritanserin on WDS latency was more evident in GEPR-9s than in SD, and hippocampal expression of activity-regulated cytoskeleton-associated protein paralleled the severity of WDS. The results suggest that downstream serotonergic synaptic activation is less pronounced in GEPR-9s than in SD and that the serotonergic agent may directly activate postsynaptic 5-HT2A receptors in both strains.

Original language	English
Pages (from-to)	401-404
Number of pages	4
Journal	Journal of Pharmacological Sciences
Volume	110
Issue number	3
DOIs	https://doi.org/10.1254/jphs.09015SC
Publication status	Published - 2009

Keywords

Genetically epilepsy-prone rat
Kainic acid
Wet dog shake

ASJC Scopus subject areas

Molecular Medicine
Pharmacology

Access to Document

10.1254/jphs.09015SC

Cite this

Decrease in the kainate-induced wet dog shake behavior in genetically epilepsy-prone rats : Possible involvement of an impaired synaptic transmission to the 5-HT_2A receptor. / Shin, Eun Joo; Ji, Hoon Jeong; Yoon, Hee Chung et al.

In: Journal of Pharmacological Sciences, Vol. 110, No. 3, 2009, p. 401-404.

Research output: Contribution to journal › Article › peer-review

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abstract = "Genetically epilepsy-prone rats (GEPR-9s) were derived from Sprague-Dawley rats (SD). The number of kainate-induced wet dog shake behavior (WDS) responses was found to decrease significantly in GEPR-9s compared to SD. WDS responses were potentiated by 5-hydroxytryptophan or 2,5-dimethoxy-4-iodoamphetamine and antagonized by ritanserin. The antagonizing effect of ritanserin on WDS latency was more evident in GEPR-9s than in SD, and hippocampal expression of activity-regulated cytoskeleton-associated protein paralleled the severity of WDS. The results suggest that downstream serotonergic synaptic activation is less pronounced in GEPR-9s than in SD and that the serotonergic agent may directly activate postsynaptic 5-HT2A receptors in both strains.",

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