Abstract
Background Recent studies have reported that adiponectin-mediated neuromolecular pathways are involved in fear extinction, implying that adiponectin may be an important biological marker for posttraumatic stress disorder (PTSD). However, no study has investigated the association between adiponectin and patients with PTSD. Methods We examined plasma adiponectin levels, high-sensitivity C-reactive protein (hs-CRP), and psychopathological factors using the Korean version of the Impact Event Scale-Revised (IES-R-K) and the Center for Epidemiologic Studies Depression Scale in 507 male firefighters. The PTSD symptom group was defined as those with a score of 25 or higher on the IES-R-K. Multiple logistic regression analysis was conducted to examine the covariates for the PTSD symptom group. Results Out of 507 male firefighters, 139 (27.4%) had a score of 25 or more on the IES-R-K. The PTSD symptom group had lower plasma adiponectin levels than the controls. There was an inverse correlation between plasma adiponectin levels and PTSD severity. There was no correlation between adiponectin levels and depression. The adiponectin level was associated with the presence of PTSD symptom (odds ratio = 0.955, 95% CI = 0.920–0.991). Limitations A cross-sectional design and using self-rated instruments. Conclusions To the best of our knowledge, the results showed that decreased adiponectin-mediated activity is associated with PTSD. Future studies are necessary to identify the causative role of adiponectin for PTSD as well as any possible covariates.
| Original language | English |
|---|---|
| Pages (from-to) | 254-258 |
| Number of pages | 5 |
| Journal | Journal of Affective Disorders |
| Volume | 221 |
| DOIs | |
| Publication status | Published - 2017 Oct 15 |
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Keywords
- Adiponectin
- C-reactive protein
- Posttraumatic stress disorder
ASJC Scopus subject areas
- Clinical Psychology
- Psychiatry and Mental health
Cite this
Decreased plasma adiponectin among male firefighters with symptoms of post-traumatic stress disorder. / Na, Kyoung Sa; Kim, Eun Kyoung; Park, Jong Tae.
In: Journal of Affective Disorders, Vol. 221, 15.10.2017, p. 254-258.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Decreased plasma adiponectin among male firefighters with symptoms of post-traumatic stress disorder
AU - Na, Kyoung Sa
AU - Kim, Eun Kyoung
AU - Park, Jong Tae
PY - 2017/10/15
Y1 - 2017/10/15
N2 - Background Recent studies have reported that adiponectin-mediated neuromolecular pathways are involved in fear extinction, implying that adiponectin may be an important biological marker for posttraumatic stress disorder (PTSD). However, no study has investigated the association between adiponectin and patients with PTSD. Methods We examined plasma adiponectin levels, high-sensitivity C-reactive protein (hs-CRP), and psychopathological factors using the Korean version of the Impact Event Scale-Revised (IES-R-K) and the Center for Epidemiologic Studies Depression Scale in 507 male firefighters. The PTSD symptom group was defined as those with a score of 25 or higher on the IES-R-K. Multiple logistic regression analysis was conducted to examine the covariates for the PTSD symptom group. Results Out of 507 male firefighters, 139 (27.4%) had a score of 25 or more on the IES-R-K. The PTSD symptom group had lower plasma adiponectin levels than the controls. There was an inverse correlation between plasma adiponectin levels and PTSD severity. There was no correlation between adiponectin levels and depression. The adiponectin level was associated with the presence of PTSD symptom (odds ratio = 0.955, 95% CI = 0.920–0.991). Limitations A cross-sectional design and using self-rated instruments. Conclusions To the best of our knowledge, the results showed that decreased adiponectin-mediated activity is associated with PTSD. Future studies are necessary to identify the causative role of adiponectin for PTSD as well as any possible covariates.
AB - Background Recent studies have reported that adiponectin-mediated neuromolecular pathways are involved in fear extinction, implying that adiponectin may be an important biological marker for posttraumatic stress disorder (PTSD). However, no study has investigated the association between adiponectin and patients with PTSD. Methods We examined plasma adiponectin levels, high-sensitivity C-reactive protein (hs-CRP), and psychopathological factors using the Korean version of the Impact Event Scale-Revised (IES-R-K) and the Center for Epidemiologic Studies Depression Scale in 507 male firefighters. The PTSD symptom group was defined as those with a score of 25 or higher on the IES-R-K. Multiple logistic regression analysis was conducted to examine the covariates for the PTSD symptom group. Results Out of 507 male firefighters, 139 (27.4%) had a score of 25 or more on the IES-R-K. The PTSD symptom group had lower plasma adiponectin levels than the controls. There was an inverse correlation between plasma adiponectin levels and PTSD severity. There was no correlation between adiponectin levels and depression. The adiponectin level was associated with the presence of PTSD symptom (odds ratio = 0.955, 95% CI = 0.920–0.991). Limitations A cross-sectional design and using self-rated instruments. Conclusions To the best of our knowledge, the results showed that decreased adiponectin-mediated activity is associated with PTSD. Future studies are necessary to identify the causative role of adiponectin for PTSD as well as any possible covariates.
KW - Adiponectin
KW - C-reactive protein
KW - Posttraumatic stress disorder
UR - http://www.scopus.com/inward/record.url?scp=85021214540&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85021214540&partnerID=8YFLogxK
U2 - 10.1016/j.jad.2017.06.015
DO - 10.1016/j.jad.2017.06.015
M3 - Article
C2 - 28662456
AN - SCOPUS:85021214540
VL - 221
SP - 254
EP - 258
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
SN - 0165-0327
ER -