We report here two adult female patients with bipolar disorder who developed abnormal thyroid function after short-or long-term administration of valproic acid (VPA). The first patient developed sick euthyroid syndrome (relative to her pretreatment thyroid levels) after only 2 months of treatment with VPA and quetiapine. The second patient, who had no pretreatment medical history including thyroid disease, developed hypothyroidism after several years of treatment with VPA and quetiapine.
|Journal||General Hospital Psychiatry|
|Publication status||Published - 2011 Mar 1|
- Sick euthyroid syndrome
- Thyroid function
- Valproic acid
ASJC Scopus subject areas
- Psychiatry and Mental health