Decreased umbilical orexin-A level is associated with idiopathic polyhydramnios

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective. To evaluate the association between orexin-A level and idiopathic polyhydramnios. Design. Case-control study. Setting. Tertiary-level university hospital. Population. Ten term pregnant women with idiopathic polyhydramnios and, as the control group, 20 pregnant women with normal amniotic fluid levels. Methods. Amniotic fluid level was measured at admission for delivery using enzyme-linked immunosorbent assay. Maternal blood was obtained from a cannulated vein immediately before delivery, and umbilical blood was collected at the time of delivery, before the separation of the placenta. Main outcome measures. Maternal and umbilical levels of orexin-A. Results. Mean umbilical serum orexin-A level was significantly lower than maternal serum orexin-A level. Umbilical serum orexin-A level was positively correlated with maternal serum orexin-A level, but negatively correlated with amniotic fluid index and birthweight. Umbilical serum orexin-A level was lower in the idiopathic polyhydramnios group than in the control group. However, no difference in maternal serum orexin-A level was observed between the two groups. Conclusions. Idiopathic polyhydramnios was associated with decreased umbilical serum orexin-A levels. Our results provide evidence that orexin-A expression may be involved in amniotic fluid regulation, causing polyhydramnios by downregulation.

Original languageEnglish
Pages (from-to)295-300
Number of pages6
JournalActa Obstetricia et Gynecologica Scandinavica
Volume94
Issue number3
DOIs
Publication statusPublished - 2015 Mar 1

Fingerprint

Polyhydramnios
Umbilicus
Amniotic Fluid
Mothers
Serum
Pregnant Women
Orexins
Control Groups
Placenta
Case-Control Studies
Veins
Down-Regulation
Enzyme-Linked Immunosorbent Assay
Outcome Assessment (Health Care)

Keywords

  • amniotic fluid
  • Orexin-A
  • placenta
  • polyhydramnios
  • umbilical cord

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

@article{a9f61cf9bc9b4c06aeccae085fa51d0b,
title = "Decreased umbilical orexin-A level is associated with idiopathic polyhydramnios",
abstract = "Objective. To evaluate the association between orexin-A level and idiopathic polyhydramnios. Design. Case-control study. Setting. Tertiary-level university hospital. Population. Ten term pregnant women with idiopathic polyhydramnios and, as the control group, 20 pregnant women with normal amniotic fluid levels. Methods. Amniotic fluid level was measured at admission for delivery using enzyme-linked immunosorbent assay. Maternal blood was obtained from a cannulated vein immediately before delivery, and umbilical blood was collected at the time of delivery, before the separation of the placenta. Main outcome measures. Maternal and umbilical levels of orexin-A. Results. Mean umbilical serum orexin-A level was significantly lower than maternal serum orexin-A level. Umbilical serum orexin-A level was positively correlated with maternal serum orexin-A level, but negatively correlated with amniotic fluid index and birthweight. Umbilical serum orexin-A level was lower in the idiopathic polyhydramnios group than in the control group. However, no difference in maternal serum orexin-A level was observed between the two groups. Conclusions. Idiopathic polyhydramnios was associated with decreased umbilical serum orexin-A levels. Our results provide evidence that orexin-A expression may be involved in amniotic fluid regulation, causing polyhydramnios by downregulation.",
keywords = "amniotic fluid, Orexin-A, placenta, polyhydramnios, umbilical cord",
author = "Geum-Joon Cho and Hong, {Hye Ri} and Kim, {Suhng Wook} and Hong, {Soon Cheol} and Oh, {Min Jeong} and Kim, {Hai Joong}",
year = "2015",
month = "3",
day = "1",
doi = "10.1111/aogs.12559",
language = "English",
volume = "94",
pages = "295--300",
journal = "Acta Obstetricia et Gynecologica Scandinavica",
issn = "0001-6349",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - Decreased umbilical orexin-A level is associated with idiopathic polyhydramnios

AU - Cho, Geum-Joon

AU - Hong, Hye Ri

AU - Kim, Suhng Wook

AU - Hong, Soon Cheol

AU - Oh, Min Jeong

AU - Kim, Hai Joong

PY - 2015/3/1

Y1 - 2015/3/1

N2 - Objective. To evaluate the association between orexin-A level and idiopathic polyhydramnios. Design. Case-control study. Setting. Tertiary-level university hospital. Population. Ten term pregnant women with idiopathic polyhydramnios and, as the control group, 20 pregnant women with normal amniotic fluid levels. Methods. Amniotic fluid level was measured at admission for delivery using enzyme-linked immunosorbent assay. Maternal blood was obtained from a cannulated vein immediately before delivery, and umbilical blood was collected at the time of delivery, before the separation of the placenta. Main outcome measures. Maternal and umbilical levels of orexin-A. Results. Mean umbilical serum orexin-A level was significantly lower than maternal serum orexin-A level. Umbilical serum orexin-A level was positively correlated with maternal serum orexin-A level, but negatively correlated with amniotic fluid index and birthweight. Umbilical serum orexin-A level was lower in the idiopathic polyhydramnios group than in the control group. However, no difference in maternal serum orexin-A level was observed between the two groups. Conclusions. Idiopathic polyhydramnios was associated with decreased umbilical serum orexin-A levels. Our results provide evidence that orexin-A expression may be involved in amniotic fluid regulation, causing polyhydramnios by downregulation.

AB - Objective. To evaluate the association between orexin-A level and idiopathic polyhydramnios. Design. Case-control study. Setting. Tertiary-level university hospital. Population. Ten term pregnant women with idiopathic polyhydramnios and, as the control group, 20 pregnant women with normal amniotic fluid levels. Methods. Amniotic fluid level was measured at admission for delivery using enzyme-linked immunosorbent assay. Maternal blood was obtained from a cannulated vein immediately before delivery, and umbilical blood was collected at the time of delivery, before the separation of the placenta. Main outcome measures. Maternal and umbilical levels of orexin-A. Results. Mean umbilical serum orexin-A level was significantly lower than maternal serum orexin-A level. Umbilical serum orexin-A level was positively correlated with maternal serum orexin-A level, but negatively correlated with amniotic fluid index and birthweight. Umbilical serum orexin-A level was lower in the idiopathic polyhydramnios group than in the control group. However, no difference in maternal serum orexin-A level was observed between the two groups. Conclusions. Idiopathic polyhydramnios was associated with decreased umbilical serum orexin-A levels. Our results provide evidence that orexin-A expression may be involved in amniotic fluid regulation, causing polyhydramnios by downregulation.

KW - amniotic fluid

KW - Orexin-A

KW - placenta

KW - polyhydramnios

KW - umbilical cord

UR - http://www.scopus.com/inward/record.url?scp=84923102449&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84923102449&partnerID=8YFLogxK

U2 - 10.1111/aogs.12559

DO - 10.1111/aogs.12559

M3 - Article

C2 - 25494826

AN - SCOPUS:84923102449

VL - 94

SP - 295

EP - 300

JO - Acta Obstetricia et Gynecologica Scandinavica

JF - Acta Obstetricia et Gynecologica Scandinavica

SN - 0001-6349

IS - 3

ER -