Decursin: A cytotoxic agent and protein kinase C activator from the root of Angelica gigas

Kyung Seop Ahn, Woong Seop Sim, Ik Hwan Kim

Research output: Contribution to journalArticle

97 Citations (Scopus)

Abstract

A cytotoxic compound was purified from the root of Angelica gigas Nakai by silica gel chromatography and preparative HPLC. As a result of the structure analysis by mass, IR, 1H-NMR, and 13C-NMR spectrometry, the effective compound was identified as decursin, a pyranocoumarin characterized originally from Angelica decursiva Fr. et Sav. In vitro cytotoxicity testing showed that decursin displayed toxic activity against various human cancer cell lines, for which the ED50 of decursin was about 5-16 μg/ml. On the other hand, decursin displayed relatively low cytotoxicity against normal fibroblasts. Decursin also activated protein kinase C (PKC) in vitro, which indicates that the cytotoxic activity of decursin may be related to the protein kinase C activation.

Original languageEnglish
Pages (from-to)7-9
Number of pages3
JournalPlanta Medica
Volume62
Issue number1
DOIs
Publication statusPublished - 1996 Feb 15
Externally publishedYes

Fingerprint

Angelica gigas
Angelica
Cytotoxins
protein kinase C
Protein Kinase C
cytotoxicity
silica gel
fibroblasts
spectroscopy
high performance liquid chromatography
cell lines
Cytotoxicity
Pyranocoumarins
Nuclear magnetic resonance
Poisons
Silica Gel
testing
Fibroblasts
Chromatography
Spectrometry

Keywords

  • Angelica gigas Nakai
  • cytotoxic activity
  • decursin
  • protein kinase C activation
  • umbelliferae

ASJC Scopus subject areas

  • Plant Science
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

Cite this

Decursin : A cytotoxic agent and protein kinase C activator from the root of Angelica gigas. / Ahn, Kyung Seop; Sim, Woong Seop; Kim, Ik Hwan.

In: Planta Medica, Vol. 62, No. 1, 15.02.1996, p. 7-9.

Research output: Contribution to journalArticle

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