Abstract
We evaluated the anti-osteoarthritic effects of deer bone extract on articular cartilage damage by using micro-computed tomography (micro-CT) in monosodium iodoacetate (MIA)-induced osteoarthritis (OA) in rats. Male Wistar rats (6 weeks of age) were randomly divided into 5 groups (10 rats/group): sham control (SC; PBS injection+PBS 1mL treatment); negative control (NC; MIA injection+PBS 1mL treatment); positive control (PC; MIA injection+250mg/kg glucosamine sulfate/chondroitin sulfate mixture treatment); low dose (LDB; MIA injection+250mg/kg deer bone extract treatment); and high dose (HDB; MIA injection+500mg/kg deer bone extract treatment). After 50 days of treatment, we observed that the administration of deer bone extract protected against bone destruction and reduced the number of erosion lacunae. When deer bone extract was administered, the trabecular thickness distribution (Tb.Th) (LDB: 75.9 μm, HDB: 80.7 μm vs. NC: 48.0 μm) and the trabecular bone volume fraction ratio (BV/TV) (LDB: 43.8%, HDB: 48.2% vs. NC: 39.1%) were significantly restored. Additionally, the trabecular separation (Tb.Sp) increase caused by MIA was decreased significantly with the administration of deer bone extract (LDB: 73.4 μm, HDB: 81.2 μm vs. NC: 112.0 μm). We concluded that the oral administration of deer bone extract effectively relieved the morphological changes induced by MIA injection in an animal model.
| Original language | English |
|---|---|
| Pages (from-to) | 701-706 |
| Number of pages | 6 |
| Journal | Journal of Medicinal Food |
| Volume | 17 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2014 Jun 1 |
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ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics
Cite this
Deer bone extract suppresses articular cartilage damage induced by monosodium iodoacetate in osteoarthritic rats : An in vivo micro-computed tomography study. / Lee, Hyunji; Park, Yooheon; Ahn, Chang Won; Park, Soo Hyun; Jung, Eun Young; Suh, Hyung Joo.
In: Journal of Medicinal Food, Vol. 17, No. 6, 01.06.2014, p. 701-706.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Deer bone extract suppresses articular cartilage damage induced by monosodium iodoacetate in osteoarthritic rats
T2 - An in vivo micro-computed tomography study
AU - Lee, Hyunji
AU - Park, Yooheon
AU - Ahn, Chang Won
AU - Park, Soo Hyun
AU - Jung, Eun Young
AU - Suh, Hyung Joo
PY - 2014/6/1
Y1 - 2014/6/1
N2 - We evaluated the anti-osteoarthritic effects of deer bone extract on articular cartilage damage by using micro-computed tomography (micro-CT) in monosodium iodoacetate (MIA)-induced osteoarthritis (OA) in rats. Male Wistar rats (6 weeks of age) were randomly divided into 5 groups (10 rats/group): sham control (SC; PBS injection+PBS 1mL treatment); negative control (NC; MIA injection+PBS 1mL treatment); positive control (PC; MIA injection+250mg/kg glucosamine sulfate/chondroitin sulfate mixture treatment); low dose (LDB; MIA injection+250mg/kg deer bone extract treatment); and high dose (HDB; MIA injection+500mg/kg deer bone extract treatment). After 50 days of treatment, we observed that the administration of deer bone extract protected against bone destruction and reduced the number of erosion lacunae. When deer bone extract was administered, the trabecular thickness distribution (Tb.Th) (LDB: 75.9 μm, HDB: 80.7 μm vs. NC: 48.0 μm) and the trabecular bone volume fraction ratio (BV/TV) (LDB: 43.8%, HDB: 48.2% vs. NC: 39.1%) were significantly restored. Additionally, the trabecular separation (Tb.Sp) increase caused by MIA was decreased significantly with the administration of deer bone extract (LDB: 73.4 μm, HDB: 81.2 μm vs. NC: 112.0 μm). We concluded that the oral administration of deer bone extract effectively relieved the morphological changes induced by MIA injection in an animal model.
AB - We evaluated the anti-osteoarthritic effects of deer bone extract on articular cartilage damage by using micro-computed tomography (micro-CT) in monosodium iodoacetate (MIA)-induced osteoarthritis (OA) in rats. Male Wistar rats (6 weeks of age) were randomly divided into 5 groups (10 rats/group): sham control (SC; PBS injection+PBS 1mL treatment); negative control (NC; MIA injection+PBS 1mL treatment); positive control (PC; MIA injection+250mg/kg glucosamine sulfate/chondroitin sulfate mixture treatment); low dose (LDB; MIA injection+250mg/kg deer bone extract treatment); and high dose (HDB; MIA injection+500mg/kg deer bone extract treatment). After 50 days of treatment, we observed that the administration of deer bone extract protected against bone destruction and reduced the number of erosion lacunae. When deer bone extract was administered, the trabecular thickness distribution (Tb.Th) (LDB: 75.9 μm, HDB: 80.7 μm vs. NC: 48.0 μm) and the trabecular bone volume fraction ratio (BV/TV) (LDB: 43.8%, HDB: 48.2% vs. NC: 39.1%) were significantly restored. Additionally, the trabecular separation (Tb.Sp) increase caused by MIA was decreased significantly with the administration of deer bone extract (LDB: 73.4 μm, HDB: 81.2 μm vs. NC: 112.0 μm). We concluded that the oral administration of deer bone extract effectively relieved the morphological changes induced by MIA injection in an animal model.
KW - Deer bone
KW - Micro-computed tomography
KW - Monosodium iodoacetate
KW - Osteoarthritis
UR - http://www.scopus.com/inward/record.url?scp=84902455705&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84902455705&partnerID=8YFLogxK
U2 - 10.1089/jmf.2013.2959
DO - 10.1089/jmf.2013.2959
M3 - Article
C2 - 24797662
AN - SCOPUS:84902455705
VL - 17
SP - 701
EP - 706
JO - Journal of Medicinal Food
JF - Journal of Medicinal Food
SN - 1096-620X
IS - 6
ER -