Deer bone extract suppresses articular cartilage damage induced by monosodium iodoacetate in osteoarthritic rats: An in vivo micro-computed tomography study

Hyunji Lee, Yooheon Park, Chang Won Ahn, Soo Hyun Park, Eun Young Jung, Hyung Joo Suh

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We evaluated the anti-osteoarthritic effects of deer bone extract on articular cartilage damage by using micro-computed tomography (micro-CT) in monosodium iodoacetate (MIA)-induced osteoarthritis (OA) in rats. Male Wistar rats (6 weeks of age) were randomly divided into 5 groups (10 rats/group): sham control (SC; PBS injection+PBS 1mL treatment); negative control (NC; MIA injection+PBS 1mL treatment); positive control (PC; MIA injection+250mg/kg glucosamine sulfate/chondroitin sulfate mixture treatment); low dose (LDB; MIA injection+250mg/kg deer bone extract treatment); and high dose (HDB; MIA injection+500mg/kg deer bone extract treatment). After 50 days of treatment, we observed that the administration of deer bone extract protected against bone destruction and reduced the number of erosion lacunae. When deer bone extract was administered, the trabecular thickness distribution (Tb.Th) (LDB: 75.9 μm, HDB: 80.7 μm vs. NC: 48.0 μm) and the trabecular bone volume fraction ratio (BV/TV) (LDB: 43.8%, HDB: 48.2% vs. NC: 39.1%) were significantly restored. Additionally, the trabecular separation (Tb.Sp) increase caused by MIA was decreased significantly with the administration of deer bone extract (LDB: 73.4 μm, HDB: 81.2 μm vs. NC: 112.0 μm). We concluded that the oral administration of deer bone extract effectively relieved the morphological changes induced by MIA injection in an animal model.

Original languageEnglish
Pages (from-to)701-706
Number of pages6
JournalJournal of Medicinal Food
Volume17
Issue number6
DOIs
Publication statusPublished - 2014 Jun 1

Fingerprint

Iodoacetates
Deer
Articular Cartilage
Tomography
Bone and Bones
Injections
Therapeutics
Chondroitin Sulfates
Glucosamine
Osteoarthritis
Oral Administration
Wistar Rats
Animal Models
Control Groups

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Deer bone extract suppresses articular cartilage damage induced by monosodium iodoacetate in osteoarthritic rats : An in vivo micro-computed tomography study. / Lee, Hyunji; Park, Yooheon; Ahn, Chang Won; Park, Soo Hyun; Jung, Eun Young; Suh, Hyung Joo.

In: Journal of Medicinal Food, Vol. 17, No. 6, 01.06.2014, p. 701-706.

Research output: Contribution to journalArticle

@article{bd97ecadb90144638fa00c3e8c62ca02,
title = "Deer bone extract suppresses articular cartilage damage induced by monosodium iodoacetate in osteoarthritic rats: An in vivo micro-computed tomography study",
abstract = "We evaluated the anti-osteoarthritic effects of deer bone extract on articular cartilage damage by using micro-computed tomography (micro-CT) in monosodium iodoacetate (MIA)-induced osteoarthritis (OA) in rats. Male Wistar rats (6 weeks of age) were randomly divided into 5 groups (10 rats/group): sham control (SC; PBS injection+PBS 1mL treatment); negative control (NC; MIA injection+PBS 1mL treatment); positive control (PC; MIA injection+250mg/kg glucosamine sulfate/chondroitin sulfate mixture treatment); low dose (LDB; MIA injection+250mg/kg deer bone extract treatment); and high dose (HDB; MIA injection+500mg/kg deer bone extract treatment). After 50 days of treatment, we observed that the administration of deer bone extract protected against bone destruction and reduced the number of erosion lacunae. When deer bone extract was administered, the trabecular thickness distribution (Tb.Th) (LDB: 75.9 μm, HDB: 80.7 μm vs. NC: 48.0 μm) and the trabecular bone volume fraction ratio (BV/TV) (LDB: 43.8{\%}, HDB: 48.2{\%} vs. NC: 39.1{\%}) were significantly restored. Additionally, the trabecular separation (Tb.Sp) increase caused by MIA was decreased significantly with the administration of deer bone extract (LDB: 73.4 μm, HDB: 81.2 μm vs. NC: 112.0 μm). We concluded that the oral administration of deer bone extract effectively relieved the morphological changes induced by MIA injection in an animal model.",
keywords = "Deer bone, Micro-computed tomography, Monosodium iodoacetate, Osteoarthritis",
author = "Hyunji Lee and Yooheon Park and Ahn, {Chang Won} and Park, {Soo Hyun} and Jung, {Eun Young} and Suh, {Hyung Joo}",
year = "2014",
month = "6",
day = "1",
doi = "10.1089/jmf.2013.2959",
language = "English",
volume = "17",
pages = "701--706",
journal = "Journal of Medicinal Food",
issn = "1096-620X",
publisher = "Mary Ann Liebert Inc.",
number = "6",

}

TY - JOUR

T1 - Deer bone extract suppresses articular cartilage damage induced by monosodium iodoacetate in osteoarthritic rats

T2 - An in vivo micro-computed tomography study

AU - Lee, Hyunji

AU - Park, Yooheon

AU - Ahn, Chang Won

AU - Park, Soo Hyun

AU - Jung, Eun Young

AU - Suh, Hyung Joo

PY - 2014/6/1

Y1 - 2014/6/1

N2 - We evaluated the anti-osteoarthritic effects of deer bone extract on articular cartilage damage by using micro-computed tomography (micro-CT) in monosodium iodoacetate (MIA)-induced osteoarthritis (OA) in rats. Male Wistar rats (6 weeks of age) were randomly divided into 5 groups (10 rats/group): sham control (SC; PBS injection+PBS 1mL treatment); negative control (NC; MIA injection+PBS 1mL treatment); positive control (PC; MIA injection+250mg/kg glucosamine sulfate/chondroitin sulfate mixture treatment); low dose (LDB; MIA injection+250mg/kg deer bone extract treatment); and high dose (HDB; MIA injection+500mg/kg deer bone extract treatment). After 50 days of treatment, we observed that the administration of deer bone extract protected against bone destruction and reduced the number of erosion lacunae. When deer bone extract was administered, the trabecular thickness distribution (Tb.Th) (LDB: 75.9 μm, HDB: 80.7 μm vs. NC: 48.0 μm) and the trabecular bone volume fraction ratio (BV/TV) (LDB: 43.8%, HDB: 48.2% vs. NC: 39.1%) were significantly restored. Additionally, the trabecular separation (Tb.Sp) increase caused by MIA was decreased significantly with the administration of deer bone extract (LDB: 73.4 μm, HDB: 81.2 μm vs. NC: 112.0 μm). We concluded that the oral administration of deer bone extract effectively relieved the morphological changes induced by MIA injection in an animal model.

AB - We evaluated the anti-osteoarthritic effects of deer bone extract on articular cartilage damage by using micro-computed tomography (micro-CT) in monosodium iodoacetate (MIA)-induced osteoarthritis (OA) in rats. Male Wistar rats (6 weeks of age) were randomly divided into 5 groups (10 rats/group): sham control (SC; PBS injection+PBS 1mL treatment); negative control (NC; MIA injection+PBS 1mL treatment); positive control (PC; MIA injection+250mg/kg glucosamine sulfate/chondroitin sulfate mixture treatment); low dose (LDB; MIA injection+250mg/kg deer bone extract treatment); and high dose (HDB; MIA injection+500mg/kg deer bone extract treatment). After 50 days of treatment, we observed that the administration of deer bone extract protected against bone destruction and reduced the number of erosion lacunae. When deer bone extract was administered, the trabecular thickness distribution (Tb.Th) (LDB: 75.9 μm, HDB: 80.7 μm vs. NC: 48.0 μm) and the trabecular bone volume fraction ratio (BV/TV) (LDB: 43.8%, HDB: 48.2% vs. NC: 39.1%) were significantly restored. Additionally, the trabecular separation (Tb.Sp) increase caused by MIA was decreased significantly with the administration of deer bone extract (LDB: 73.4 μm, HDB: 81.2 μm vs. NC: 112.0 μm). We concluded that the oral administration of deer bone extract effectively relieved the morphological changes induced by MIA injection in an animal model.

KW - Deer bone

KW - Micro-computed tomography

KW - Monosodium iodoacetate

KW - Osteoarthritis

UR - http://www.scopus.com/inward/record.url?scp=84902455705&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84902455705&partnerID=8YFLogxK

U2 - 10.1089/jmf.2013.2959

DO - 10.1089/jmf.2013.2959

M3 - Article

C2 - 24797662

AN - SCOPUS:84902455705

VL - 17

SP - 701

EP - 706

JO - Journal of Medicinal Food

JF - Journal of Medicinal Food

SN - 1096-620X

IS - 6

ER -