Deformable registration of brain tumor images via a statistical model of tumor-induced deformation

Ashraf Mohamed, Dinggang Shen, Christos Davatzikos

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Citations (Scopus)

Abstract

An approach to deformable registration of three-dimensional brain tumor images to a normal brain atlas is presented. The approach involves the integration of three components: a biomechanical model of tumor mass-effect, a statistical approach to estimate the model's parameters, and a deformable image registration method. Statistical properties of the desired deformation map are first obtained through tumor masseffect simulations on normal brain images. This map is decomposed into the sum of two components in orthogonal subspaces, one representing inter-individual differences, and the other involving tumor-induced deformation. For a new tumor case, a partial observation of the desired deformation map is obtained via deformable image registration and is decomposed into the aforementioned spaces in order to estimate the mass-effect model parameters. Using this estimate, a simulation of tumor mass-effect is performed on the atlas to generate an image that is more similar to brain tumor image, thereby facilitating the atlas registration process. Results for a real and a simulated tumor case indicate significant reduction in the registration error due to the presented approach as compared to the direct use of deformable image registration.

Original languageEnglish
Title of host publicationMedical Image Computing and Computer-Assisted Intervention - MICCAI 2005 - 8th International Conference, Proceedings
Pages263-270
Number of pages8
DOIs
Publication statusPublished - 2005
Externally publishedYes
Event8th International Conference on Medical Image Computing and Computer-Assisted Intervention - MICCAI 2005 - Palm Springs, CA, United States
Duration: 2005 Oct 262005 Oct 29

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume3750 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Other

Other8th International Conference on Medical Image Computing and Computer-Assisted Intervention - MICCAI 2005
CountryUnited States
CityPalm Springs, CA
Period05/10/2605/10/29

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

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    Mohamed, A., Shen, D., & Davatzikos, C. (2005). Deformable registration of brain tumor images via a statistical model of tumor-induced deformation. In Medical Image Computing and Computer-Assisted Intervention - MICCAI 2005 - 8th International Conference, Proceedings (pp. 263-270). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 3750 LNCS). https://doi.org/10.1007/11566489_33