Deformities of the Globus Pallidus are Associated with Severity of Suicidal Ideation and Impulsivity in Patients with Major Depressive Disorder

Kiwon Kim, Jeong Hyeon Shin, Woojae Myung, Maurizio Fava, David Mischoulon, George I. Papakostas, Kwan Woo Choi, Eun Jin Na, Sang Won Seo, Jun Kyung Seong, Hong Jin Jeon

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Neuroimaging research increasingly suggests there are biological features related to suicidal risk, including brain morphometric features, leading to an elaborate suicide risk assessment. However, few studies have focused on the severity of suicidal ideation and its association with subcortical anatomy in patients with major depressive disorder (MDD). Here, we mainly investigated whether specific structural differences were present in MDD patients with and without suicidal ideation; and supplemented comparison with and without suicidal attempt. We hypothesized that structures associated with suicidal ideation would be derived from a combination of depression and impulsivity. Local atrophy of subcortical structures in 48 patients with MDD (24 with suicidal ideation and 24 without) and 25 age- and sex-matched healthy controls were compared using a surface-based shape analysis method. There was no difference in brain volume between MDD patients with or without suicidal ideations; or MDD patients with or without suicidal attempt. However, the atrophy level in the left pallidum showed a positive correlation with severity of suicidal risk in MDD patients with suicidal ideation. Local atrophy of the left hippocampus, right caudate, and right pallidum had a positive correlation with total impulsivity. These findings possibly suggest that vulnerability to suicidal attempt can be derived from suicidal ideation combined with depression and impulsivity, related to reduced motivational control.

Original languageEnglish
Article number7462
JournalScientific Reports
Volume9
Issue number1
DOIs
Publication statusPublished - 2019 Dec 1

Fingerprint

Suicidal Ideation
Globus Pallidus
Impulsive Behavior
Major Depressive Disorder
Atrophy
Depression
Brain
Neuroimaging
Suicide
Hippocampus
Anatomy
Research

ASJC Scopus subject areas

  • General

Cite this

Deformities of the Globus Pallidus are Associated with Severity of Suicidal Ideation and Impulsivity in Patients with Major Depressive Disorder. / Kim, Kiwon; Shin, Jeong Hyeon; Myung, Woojae; Fava, Maurizio; Mischoulon, David; Papakostas, George I.; Choi, Kwan Woo; Na, Eun Jin; Seo, Sang Won; Seong, Jun Kyung; Jeon, Hong Jin.

In: Scientific Reports, Vol. 9, No. 1, 7462, 01.12.2019.

Research output: Contribution to journalArticle

Kim, Kiwon ; Shin, Jeong Hyeon ; Myung, Woojae ; Fava, Maurizio ; Mischoulon, David ; Papakostas, George I. ; Choi, Kwan Woo ; Na, Eun Jin ; Seo, Sang Won ; Seong, Jun Kyung ; Jeon, Hong Jin. / Deformities of the Globus Pallidus are Associated with Severity of Suicidal Ideation and Impulsivity in Patients with Major Depressive Disorder. In: Scientific Reports. 2019 ; Vol. 9, No. 1.
@article{3ad848ca337d46cabe1596bd24503950,
title = "Deformities of the Globus Pallidus are Associated with Severity of Suicidal Ideation and Impulsivity in Patients with Major Depressive Disorder",
abstract = "Neuroimaging research increasingly suggests there are biological features related to suicidal risk, including brain morphometric features, leading to an elaborate suicide risk assessment. However, few studies have focused on the severity of suicidal ideation and its association with subcortical anatomy in patients with major depressive disorder (MDD). Here, we mainly investigated whether specific structural differences were present in MDD patients with and without suicidal ideation; and supplemented comparison with and without suicidal attempt. We hypothesized that structures associated with suicidal ideation would be derived from a combination of depression and impulsivity. Local atrophy of subcortical structures in 48 patients with MDD (24 with suicidal ideation and 24 without) and 25 age- and sex-matched healthy controls were compared using a surface-based shape analysis method. There was no difference in brain volume between MDD patients with or without suicidal ideations; or MDD patients with or without suicidal attempt. However, the atrophy level in the left pallidum showed a positive correlation with severity of suicidal risk in MDD patients with suicidal ideation. Local atrophy of the left hippocampus, right caudate, and right pallidum had a positive correlation with total impulsivity. These findings possibly suggest that vulnerability to suicidal attempt can be derived from suicidal ideation combined with depression and impulsivity, related to reduced motivational control.",
author = "Kiwon Kim and Shin, {Jeong Hyeon} and Woojae Myung and Maurizio Fava and David Mischoulon and Papakostas, {George I.} and Choi, {Kwan Woo} and Na, {Eun Jin} and Seo, {Sang Won} and Seong, {Jun Kyung} and Jeon, {Hong Jin}",
year = "2019",
month = "12",
day = "1",
doi = "10.1038/s41598-019-43882-4",
language = "English",
volume = "9",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

TY - JOUR

T1 - Deformities of the Globus Pallidus are Associated with Severity of Suicidal Ideation and Impulsivity in Patients with Major Depressive Disorder

AU - Kim, Kiwon

AU - Shin, Jeong Hyeon

AU - Myung, Woojae

AU - Fava, Maurizio

AU - Mischoulon, David

AU - Papakostas, George I.

AU - Choi, Kwan Woo

AU - Na, Eun Jin

AU - Seo, Sang Won

AU - Seong, Jun Kyung

AU - Jeon, Hong Jin

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Neuroimaging research increasingly suggests there are biological features related to suicidal risk, including brain morphometric features, leading to an elaborate suicide risk assessment. However, few studies have focused on the severity of suicidal ideation and its association with subcortical anatomy in patients with major depressive disorder (MDD). Here, we mainly investigated whether specific structural differences were present in MDD patients with and without suicidal ideation; and supplemented comparison with and without suicidal attempt. We hypothesized that structures associated with suicidal ideation would be derived from a combination of depression and impulsivity. Local atrophy of subcortical structures in 48 patients with MDD (24 with suicidal ideation and 24 without) and 25 age- and sex-matched healthy controls were compared using a surface-based shape analysis method. There was no difference in brain volume between MDD patients with or without suicidal ideations; or MDD patients with or without suicidal attempt. However, the atrophy level in the left pallidum showed a positive correlation with severity of suicidal risk in MDD patients with suicidal ideation. Local atrophy of the left hippocampus, right caudate, and right pallidum had a positive correlation with total impulsivity. These findings possibly suggest that vulnerability to suicidal attempt can be derived from suicidal ideation combined with depression and impulsivity, related to reduced motivational control.

AB - Neuroimaging research increasingly suggests there are biological features related to suicidal risk, including brain morphometric features, leading to an elaborate suicide risk assessment. However, few studies have focused on the severity of suicidal ideation and its association with subcortical anatomy in patients with major depressive disorder (MDD). Here, we mainly investigated whether specific structural differences were present in MDD patients with and without suicidal ideation; and supplemented comparison with and without suicidal attempt. We hypothesized that structures associated with suicidal ideation would be derived from a combination of depression and impulsivity. Local atrophy of subcortical structures in 48 patients with MDD (24 with suicidal ideation and 24 without) and 25 age- and sex-matched healthy controls were compared using a surface-based shape analysis method. There was no difference in brain volume between MDD patients with or without suicidal ideations; or MDD patients with or without suicidal attempt. However, the atrophy level in the left pallidum showed a positive correlation with severity of suicidal risk in MDD patients with suicidal ideation. Local atrophy of the left hippocampus, right caudate, and right pallidum had a positive correlation with total impulsivity. These findings possibly suggest that vulnerability to suicidal attempt can be derived from suicidal ideation combined with depression and impulsivity, related to reduced motivational control.

UR - http://www.scopus.com/inward/record.url?scp=85065819698&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85065819698&partnerID=8YFLogxK

U2 - 10.1038/s41598-019-43882-4

DO - 10.1038/s41598-019-43882-4

M3 - Article

C2 - 31097766

AN - SCOPUS:85065819698

VL - 9

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 7462

ER -