Deglycosylation of stilbene glucoside compounds improves inhibition of 3-hydroxy-3-methylglutaryl coenzyme a reductase and squalene synthase activities

Keun Tae Park, Jeong Keun Kim, Young Hee Lim

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The glycosylated stilbenes mulberroside A and rhapontin were converted to their aglycones (oxyresveratrol and rhapontigenin) by enzymatic transformation. Rhapontin, rhapontigenin, mulberroside A, oxyresveratrol-3-O-glucoside, and oxyresveratrol showed inhibitory activities against 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and squalene synthase, which are key enzymes in the cholesterol biosynthesis pathway. Aglycones showed stronger inhibitory activities than their glycosylated counterparts, and methoxylated stilbenes were stronger inhibitors of both enzymes than non-methoxylated stilbenes. The inhibitory activities of the stilbene compounds were significantly different from that of a negative control group (p<0.05).

Original languageEnglish
Pages (from-to)647-651
Number of pages5
JournalFood Science and Biotechnology
Volume23
Issue number2
DOIs
Publication statusPublished - 2014 Apr

Keywords

  • HMG-CoA reductase
  • deglycosylation
  • squalene synthase
  • stilbene

ASJC Scopus subject areas

  • Biotechnology
  • Food Science
  • Applied Microbiology and Biotechnology

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