Abstract
The glycosylated stilbenes mulberroside A and rhapontin were converted to their aglycones (oxyresveratrol and rhapontigenin) by enzymatic transformation. Rhapontin, rhapontigenin, mulberroside A, oxyresveratrol-3-O-glucoside, and oxyresveratrol showed inhibitory activities against 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and squalene synthase, which are key enzymes in the cholesterol biosynthesis pathway. Aglycones showed stronger inhibitory activities than their glycosylated counterparts, and methoxylated stilbenes were stronger inhibitors of both enzymes than non-methoxylated stilbenes. The inhibitory activities of the stilbene compounds were significantly different from that of a negative control group (p<0.05).
Original language | English |
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Pages (from-to) | 647-651 |
Number of pages | 5 |
Journal | Food Science and Biotechnology |
Volume | 23 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2014 Apr |
Keywords
- HMG-CoA reductase
- deglycosylation
- squalene synthase
- stilbene
ASJC Scopus subject areas
- Biotechnology
- Food Science
- Applied Microbiology and Biotechnology