Dehydrozingerone exerts beneficial metabolic effects in high-fat diet-induced obese mice via AMPK activation in skeletal muscle

Su Jin Kim, Hong Min Kim, Eun Soo Lee, Nami Kim, Jung Ok Lee, Hye Jeong Lee, Na Yeon Park, Joo Yeon Jo, Bo Young Ham, Si Hyun Han, Sun-Hwa Park, Choon Hee Chung, Hyeon Soo Kim

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Dehydrozingerone (DHZ) exerts beneficial effects on human health; however, its mechanism of action remains unclear. Here, we found that DHZ suppressed high-fat diet-induced weight gain, lipid accumulation and hyperglycaemia in C57BL/6 mice and increased AMP-activated protein kinase (AMPK) phosphorylation and stimulated glucose uptake in C2C12 skeletal muscle cells. DHZ activated p38 mitogen-activated protein kinase (MAPK) signalling in an AMPK-dependent manner. Inhibiting AMPK or p38 MAPK blocked DHZ-induced glucose uptake. DHZ increased GLUT4 (major transporter for glucose uptake) expression in skeletal muscle. Glucose clearance and insulin-induced glucose uptake increased in DHZ-fed animals, suggesting that DHZ increases systemic insulin sensitivity in vivo. Thus, the beneficial health effects of DHZ could possibly be explained by its ability to activate the AMPK pathway in skeletal muscle.

Original languageEnglish
Pages (from-to)620-629
Number of pages10
JournalJournal of Cellular and Molecular Medicine
Volume19
Issue number3
DOIs
Publication statusPublished - 2015 Mar 1

Keywords

  • AMPK
  • Curcumin analogue
  • Dehydrozingerone
  • Glucose uptake
  • Metabolism

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Medicine

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  • Cite this

    Kim, S. J., Kim, H. M., Lee, E. S., Kim, N., Lee, J. O., Lee, H. J., Park, N. Y., Jo, J. Y., Ham, B. Y., Han, S. H., Park, S-H., Chung, C. H., & Kim, H. S. (2015). Dehydrozingerone exerts beneficial metabolic effects in high-fat diet-induced obese mice via AMPK activation in skeletal muscle. Journal of Cellular and Molecular Medicine, 19(3), 620-629. https://doi.org/10.1111/jcmm.12455