Delivery strategies and potential targets for siRNA in major cancer types

So Jin Lee, Min Ju Kim, Ick Chan Kwon, Thomas M. Roberts

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Small interfering RNA (siRNA) has gained attention as a potential therapeutic reagent due to its ability to inhibit specific genes in many genetic diseases. For many years, studies of siRNA have progressively advanced toward novel treatment strategies against cancer. Cancer is caused by various mutations in hundreds of genes including both proto-oncogenes and tumor suppressor genes. In order to develop siRNAs as therapeutic agents for cancer treatment, delivery strategies for siRNA must be carefully designed and potential gene targets carefully selected for optimal anti-cancer effects. In this review, various modifications and delivery strategies for siRNA delivery are discussed. In addition, we present current thinking on target gene selection in major tumor types.

Original languageEnglish
JournalAdvanced Drug Delivery Reviews
DOIs
Publication statusAccepted/In press - 2015 Mar 20

Fingerprint

Small Interfering RNA
Neoplasms
Genes
Inborn Genetic Diseases
Proto-Oncogenes
Tumor Suppressor Genes
Mutation
Therapeutics

Keywords

  • Cancer
  • Delivery strategy of siRNAs
  • Gene target
  • SiRNA therapeutics
  • Small interfering RNA (siRNA)

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Delivery strategies and potential targets for siRNA in major cancer types. / Lee, So Jin; Kim, Min Ju; Kwon, Ick Chan; Roberts, Thomas M.

In: Advanced Drug Delivery Reviews, 20.03.2015.

Research output: Contribution to journalArticle

Lee, So Jin ; Kim, Min Ju ; Kwon, Ick Chan ; Roberts, Thomas M. / Delivery strategies and potential targets for siRNA in major cancer types. In: Advanced Drug Delivery Reviews. 2015.
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