Delphinidin ameliorates beta-amyloid-induced neurotoxicity by inhibiting calcium influx and tau hyperphosphorylation

Hyo Shin Kim, Donggeun Sul, Ji Youn Lim, Dongho Lee, Seong Soo Joo, Kwang Woo Hwang, So Young Park

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Beta-amyloid (Aβ) has been suggested to induce neurotoxicity in Alzheimer's disease. We evaluated the neuroprotective effects of delphinidin, an anthocyanidin commonly present in pigmented fruits and vegetables, against Aβ-induced toxicity. Aβ (25-35) significantly decreased the viability of PC12 cells, and this was accompanied by an increase in intracellular calcium levels and tau phosphorylation. However, treatment with delphinidin rescued PC12 cells from Aβ by attenuating the elevation of intracellular calcium levels and tau phosphorylation. Taken together, these results suggest that delphinidin protects PC12 cells against Aβ-induced toxicity by attenuating intracellular calcium influx and tau hyperphosphorylation.

Original languageEnglish
Pages (from-to)1685-1689
Number of pages5
JournalBioscience, Biotechnology and Biochemistry
Volume73
Issue number7
DOIs
Publication statusPublished - 2009

Keywords

  • Beta-amyloid
  • Calcium influx
  • Delphinidin
  • PC12 cells
  • Tau hyperphosphorylation

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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