Delphinidin ameliorates beta-amyloid-induced neurotoxicity by inhibiting calcium influx and tau hyperphosphorylation

Hyo Shin Kim, Dong Geun Sul, Ji Youn Lim, Dongho Lee, Seong Soo Joo, Kwang Woo Hwang, So Young Park

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Beta-amyloid (Aβ) has been suggested to induce neurotoxicity in Alzheimer's disease. We evaluated the neuroprotective effects of delphinidin, an anthocyanidin commonly present in pigmented fruits and vegetables, against Aβ-induced toxicity. Aβ (25-35) significantly decreased the viability of PC12 cells, and this was accompanied by an increase in intracellular calcium levels and tau phosphorylation. However, treatment with delphinidin rescued PC12 cells from Aβ by attenuating the elevation of intracellular calcium levels and tau phosphorylation. Taken together, these results suggest that delphinidin protects PC12 cells against Aβ-induced toxicity by attenuating intracellular calcium influx and tau hyperphosphorylation.

Original languageEnglish
Pages (from-to)1685-1689
Number of pages5
JournalBioscience, Biotechnology and Biochemistry
Volume73
Issue number7
DOIs
Publication statusPublished - 2009 Aug 19

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delphinidin
PC12 Cells
Amyloid
Phosphorylation
Calcium
Toxicity
Anthocyanins
Vegetables
Neuroprotective Agents
Fruits
Fruit
Alzheimer Disease

Keywords

  • Beta-amyloid
  • Calcium influx
  • Delphinidin
  • PC12 cells
  • Tau hyperphosphorylation

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Applied Microbiology and Biotechnology
  • Analytical Chemistry
  • Organic Chemistry

Cite this

Delphinidin ameliorates beta-amyloid-induced neurotoxicity by inhibiting calcium influx and tau hyperphosphorylation. / Kim, Hyo Shin; Sul, Dong Geun; Lim, Ji Youn; Lee, Dongho; Joo, Seong Soo; Hwang, Kwang Woo; Park, So Young.

In: Bioscience, Biotechnology and Biochemistry, Vol. 73, No. 7, 19.08.2009, p. 1685-1689.

Research output: Contribution to journalArticle

Kim, Hyo Shin ; Sul, Dong Geun ; Lim, Ji Youn ; Lee, Dongho ; Joo, Seong Soo ; Hwang, Kwang Woo ; Park, So Young. / Delphinidin ameliorates beta-amyloid-induced neurotoxicity by inhibiting calcium influx and tau hyperphosphorylation. In: Bioscience, Biotechnology and Biochemistry. 2009 ; Vol. 73, No. 7. pp. 1685-1689.
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