Delta-Notch signaling regulates oligodendrocyte specification

Hae Chul Park, Bruce Appel

Research output: Contribution to journalArticle

144 Citations (Scopus)

Abstract

Oligodendrocytes, the myelinating cell type of the central nervous system, arise from a ventral population of precursors that also produces motoneurons. Although the mechanisms that specify motoneuron development are well described, the mechanisms that generate oligodendrocytes from the same precursor population are largely unknown. By analysing mutant zebrafish embryos, we found that Delta-Notch signaling is required for spinal cord oligodendrocyte specification. Using a transgenic, conditional expression system, we also learned that constitutive Notch activity could promote formation of excess oligodendrocyte progenitor cells (OPCs). However, excess OPCs are induced only in ventral spinal cord at the time that OPCs normally develop. Our data provide evidence that Notch signaling maintains subsets of ventral spinal cord precursors during neuronal birth and, acting with other temporally and spatially restricted factors, specifies them for oligodendrocyte fate.

Original languageEnglish
Pages (from-to)3747-3755
Number of pages9
JournalDevelopment
Volume130
Issue number16
DOIs
Publication statusPublished - 2003 Aug 1
Externally publishedYes

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Keywords

  • CNS
  • Delta
  • Motoneurons
  • Neural precursors
  • Notch
  • Oligodendrocytes
  • Spinal cord
  • Zebrafish

ASJC Scopus subject areas

  • Cell Biology
  • Anatomy

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