TY - JOUR
T1 - Dendritic-targeting interneuron controls spike timing of hippocampal CA1 pyramidal neuron via activation of Ih
AU - Park, Sanggeon
AU - Kwag, Jeehyun
N1 - Funding Information:
This work was supported by the World Class University (WCU) program (R31-10008) and by the Basic Science Research Program (R1102941) through the National Research Foundation of Korea funded by the Ministry of Education, Science, and Technology .
Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2012/8/8
Y1 - 2012/8/8
N2 - Accurate spike timing of hippocampal CA1 pyramidal neurons relative to the on-going theta-frequency network oscillations is important in hippocampal spatial information and memory processing. Accumulating evidence suggests that inhibitory interneurons are important in regulating the activity of pyramidal neurons in the local hippocampal circuit. Interneurons synapse mostly onto the dendrites of CA1 pyramidal neurons where they are believed to take part in dendritic computation. However, it remains unclear how the diverse types of interneurons targeting different dendritic domains of pyramidal neurons differentially contribute to the precise control of spike timing during network oscillation. Here, using a full-morphology multi-compartment model of CA1 pyramidal neuron, we find that phasic inhibitory inputs during theta oscillation can precisely control spike timing of CA1 pyramidal neurons by not only delaying but also advancing the spike times. In addition, we report that the biophysical mechanism underlying the spike time advancement caused by inhibitory input is due to the hyperpolarization-activated mixed cation current (Ih) in pyramidal neuron dendrites. Thus, a wide variety of interneuron types targeting different dendritic locations of pyramidal neuron activate dendritic Ih to influence spike timing of pyramidal neuron during theta oscillation. This suggests an important functional role of dendritic-targeting interneurons in hippocampal spike timing-based information processing.
AB - Accurate spike timing of hippocampal CA1 pyramidal neurons relative to the on-going theta-frequency network oscillations is important in hippocampal spatial information and memory processing. Accumulating evidence suggests that inhibitory interneurons are important in regulating the activity of pyramidal neurons in the local hippocampal circuit. Interneurons synapse mostly onto the dendrites of CA1 pyramidal neurons where they are believed to take part in dendritic computation. However, it remains unclear how the diverse types of interneurons targeting different dendritic domains of pyramidal neurons differentially contribute to the precise control of spike timing during network oscillation. Here, using a full-morphology multi-compartment model of CA1 pyramidal neuron, we find that phasic inhibitory inputs during theta oscillation can precisely control spike timing of CA1 pyramidal neurons by not only delaying but also advancing the spike times. In addition, we report that the biophysical mechanism underlying the spike time advancement caused by inhibitory input is due to the hyperpolarization-activated mixed cation current (Ih) in pyramidal neuron dendrites. Thus, a wide variety of interneuron types targeting different dendritic locations of pyramidal neuron activate dendritic Ih to influence spike timing of pyramidal neuron during theta oscillation. This suggests an important functional role of dendritic-targeting interneurons in hippocampal spike timing-based information processing.
KW - Hippocampus
KW - Hyperpolarization-activated cation current
KW - Interneuron
KW - NEURON simulation model
KW - Spike timing
KW - Theta oscillation
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U2 - 10.1016/j.neulet.2012.06.010
DO - 10.1016/j.neulet.2012.06.010
M3 - Article
C2 - 22698581
AN - SCOPUS:84864325557
VL - 523
SP - 9
EP - 14
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 1
ER -