Abstract
Accurate spike timing of hippocampal CA1 pyramidal neurons relative to the on-going theta-frequency network oscillations is important in hippocampal spatial information and memory processing. Accumulating evidence suggests that inhibitory interneurons are important in regulating the activity of pyramidal neurons in the local hippocampal circuit. Interneurons synapse mostly onto the dendrites of CA1 pyramidal neurons where they are believed to take part in dendritic computation. However, it remains unclear how the diverse types of interneurons targeting different dendritic domains of pyramidal neurons differentially contribute to the precise control of spike timing during network oscillation. Here, using a full-morphology multi-compartment model of CA1 pyramidal neuron, we find that phasic inhibitory inputs during theta oscillation can precisely control spike timing of CA1 pyramidal neurons by not only delaying but also advancing the spike times. In addition, we report that the biophysical mechanism underlying the spike time advancement caused by inhibitory input is due to the hyperpolarization-activated mixed cation current (Ih) in pyramidal neuron dendrites. Thus, a wide variety of interneuron types targeting different dendritic locations of pyramidal neuron activate dendritic Ih to influence spike timing of pyramidal neuron during theta oscillation. This suggests an important functional role of dendritic-targeting interneurons in hippocampal spike timing-based information processing.
| Original language | English |
|---|---|
| Pages (from-to) | 9-14 |
| Number of pages | 6 |
| Journal | Neuroscience Letters |
| Volume | 523 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2012 Aug 8 |
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Keywords
- Hippocampus
- Hyperpolarization-activated cation current
- Interneuron
- NEURON simulation model
- Spike timing
- Theta oscillation
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Dendritic-targeting interneuron controls spike timing of hippocampal CA1 pyramidal neuron via activation of Ih . / Park, Sanggeon; Kwag, Jeehyun.
In: Neuroscience Letters, Vol. 523, No. 1, 08.08.2012, p. 9-14.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Dendritic-targeting interneuron controls spike timing of hippocampal CA1 pyramidal neuron via activation of Ih
AU - Park, Sanggeon
AU - Kwag, Jeehyun
PY - 2012/8/8
Y1 - 2012/8/8
N2 - Accurate spike timing of hippocampal CA1 pyramidal neurons relative to the on-going theta-frequency network oscillations is important in hippocampal spatial information and memory processing. Accumulating evidence suggests that inhibitory interneurons are important in regulating the activity of pyramidal neurons in the local hippocampal circuit. Interneurons synapse mostly onto the dendrites of CA1 pyramidal neurons where they are believed to take part in dendritic computation. However, it remains unclear how the diverse types of interneurons targeting different dendritic domains of pyramidal neurons differentially contribute to the precise control of spike timing during network oscillation. Here, using a full-morphology multi-compartment model of CA1 pyramidal neuron, we find that phasic inhibitory inputs during theta oscillation can precisely control spike timing of CA1 pyramidal neurons by not only delaying but also advancing the spike times. In addition, we report that the biophysical mechanism underlying the spike time advancement caused by inhibitory input is due to the hyperpolarization-activated mixed cation current (Ih) in pyramidal neuron dendrites. Thus, a wide variety of interneuron types targeting different dendritic locations of pyramidal neuron activate dendritic Ih to influence spike timing of pyramidal neuron during theta oscillation. This suggests an important functional role of dendritic-targeting interneurons in hippocampal spike timing-based information processing.
AB - Accurate spike timing of hippocampal CA1 pyramidal neurons relative to the on-going theta-frequency network oscillations is important in hippocampal spatial information and memory processing. Accumulating evidence suggests that inhibitory interneurons are important in regulating the activity of pyramidal neurons in the local hippocampal circuit. Interneurons synapse mostly onto the dendrites of CA1 pyramidal neurons where they are believed to take part in dendritic computation. However, it remains unclear how the diverse types of interneurons targeting different dendritic domains of pyramidal neurons differentially contribute to the precise control of spike timing during network oscillation. Here, using a full-morphology multi-compartment model of CA1 pyramidal neuron, we find that phasic inhibitory inputs during theta oscillation can precisely control spike timing of CA1 pyramidal neurons by not only delaying but also advancing the spike times. In addition, we report that the biophysical mechanism underlying the spike time advancement caused by inhibitory input is due to the hyperpolarization-activated mixed cation current (Ih) in pyramidal neuron dendrites. Thus, a wide variety of interneuron types targeting different dendritic locations of pyramidal neuron activate dendritic Ih to influence spike timing of pyramidal neuron during theta oscillation. This suggests an important functional role of dendritic-targeting interneurons in hippocampal spike timing-based information processing.
KW - Hippocampus
KW - Hyperpolarization-activated cation current
KW - Interneuron
KW - NEURON simulation model
KW - Spike timing
KW - Theta oscillation
UR - http://www.scopus.com/inward/record.url?scp=84864325557&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84864325557&partnerID=8YFLogxK
U2 - 10.1016/j.neulet.2012.06.010
DO - 10.1016/j.neulet.2012.06.010
M3 - Article
C2 - 22698581
AN - SCOPUS:84864325557
VL - 523
SP - 9
EP - 14
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 1
ER -