Dengue-associated hemophagocyticlymphohistiocytosis in an adult A case report and literature review

Sang Mi Chung, Joon-Young Song, Wonshik Kim, Min Joo Choi, Ji Ho Jeon, Seonghui Kang, Eunju Jung, Ji Yun Noh, Hee-Jin Cheong, Woo Joo Kim

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Infection-associated hemophagocytic syndrome (IAHS) is potentially a fatal disease caused by systemic infection complicated by hemophagocyticlymphohistiocytosis (HLH). Here, we report a case of HLH associated with dengue hemorrhagic fever (DHF) after a trip to Thailand. Case summary: A 33-year-old healthy female patient presented with 3 days of fever, myalgia, and skin rash. Serotype 3 dengue virus was isolated. Clinical and laboratory findings fulfilled the criteria of HLH. After the initiation of corticosteroid therapy, the patient recovered and laboratory findings were normalized. Conclusion: It would be important to differentially diagnose dengue-associated HLH from severe DHF. Early recognition and initiation of steroid treatment would be crucial for the successful treatment of dengue fever complicated by HLH.

Original languageEnglish
Article numbere6159
JournalMedicine (United States)
Volume96
Issue number8
DOIs
Publication statusPublished - 2017 Jan 1

Fingerprint

Severe Dengue
Dengue
losigame
Hemophagocytic Lymphohistiocytosis
Dengue Virus
Myalgia
Thailand
Exanthema
Adrenal Cortex Hormones
Fever
Therapeutics
Steroids
Infection

Keywords

  • Corticosteroid
  • Dengue hemorrhagic fever
  • Hemophagocyticlymphohistiocytosis
  • Severe dengue

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Dengue-associated hemophagocyticlymphohistiocytosis in an adult A case report and literature review. / Chung, Sang Mi; Song, Joon-Young; Kim, Wonshik; Choi, Min Joo; Jeon, Ji Ho; Kang, Seonghui; Jung, Eunju; Noh, Ji Yun; Cheong, Hee-Jin; Kim, Woo Joo.

In: Medicine (United States), Vol. 96, No. 8, e6159, 01.01.2017.

Research output: Contribution to journalArticle

@article{1c552ec6330e45979478620547a06140,
title = "Dengue-associated hemophagocyticlymphohistiocytosis in an adult A case report and literature review",
abstract = "Background: Infection-associated hemophagocytic syndrome (IAHS) is potentially a fatal disease caused by systemic infection complicated by hemophagocyticlymphohistiocytosis (HLH). Here, we report a case of HLH associated with dengue hemorrhagic fever (DHF) after a trip to Thailand. Case summary: A 33-year-old healthy female patient presented with 3 days of fever, myalgia, and skin rash. Serotype 3 dengue virus was isolated. Clinical and laboratory findings fulfilled the criteria of HLH. After the initiation of corticosteroid therapy, the patient recovered and laboratory findings were normalized. Conclusion: It would be important to differentially diagnose dengue-associated HLH from severe DHF. Early recognition and initiation of steroid treatment would be crucial for the successful treatment of dengue fever complicated by HLH.",
keywords = "Corticosteroid, Dengue hemorrhagic fever, Hemophagocyticlymphohistiocytosis, Severe dengue",
author = "Chung, {Sang Mi} and Joon-Young Song and Wonshik Kim and Choi, {Min Joo} and Jeon, {Ji Ho} and Seonghui Kang and Eunju Jung and Noh, {Ji Yun} and Hee-Jin Cheong and Kim, {Woo Joo}",
year = "2017",
month = "1",
day = "1",
doi = "10.1097/MD.0000000000006159",
language = "English",
volume = "96",
journal = "Medicine; analytical reviews of general medicine, neurology, psychiatry, dermatology, and pediatries",
issn = "0025-7974",
publisher = "Lippincott Williams and Wilkins",
number = "8",

}

TY - JOUR

T1 - Dengue-associated hemophagocyticlymphohistiocytosis in an adult A case report and literature review

AU - Chung, Sang Mi

AU - Song, Joon-Young

AU - Kim, Wonshik

AU - Choi, Min Joo

AU - Jeon, Ji Ho

AU - Kang, Seonghui

AU - Jung, Eunju

AU - Noh, Ji Yun

AU - Cheong, Hee-Jin

AU - Kim, Woo Joo

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Background: Infection-associated hemophagocytic syndrome (IAHS) is potentially a fatal disease caused by systemic infection complicated by hemophagocyticlymphohistiocytosis (HLH). Here, we report a case of HLH associated with dengue hemorrhagic fever (DHF) after a trip to Thailand. Case summary: A 33-year-old healthy female patient presented with 3 days of fever, myalgia, and skin rash. Serotype 3 dengue virus was isolated. Clinical and laboratory findings fulfilled the criteria of HLH. After the initiation of corticosteroid therapy, the patient recovered and laboratory findings were normalized. Conclusion: It would be important to differentially diagnose dengue-associated HLH from severe DHF. Early recognition and initiation of steroid treatment would be crucial for the successful treatment of dengue fever complicated by HLH.

AB - Background: Infection-associated hemophagocytic syndrome (IAHS) is potentially a fatal disease caused by systemic infection complicated by hemophagocyticlymphohistiocytosis (HLH). Here, we report a case of HLH associated with dengue hemorrhagic fever (DHF) after a trip to Thailand. Case summary: A 33-year-old healthy female patient presented with 3 days of fever, myalgia, and skin rash. Serotype 3 dengue virus was isolated. Clinical and laboratory findings fulfilled the criteria of HLH. After the initiation of corticosteroid therapy, the patient recovered and laboratory findings were normalized. Conclusion: It would be important to differentially diagnose dengue-associated HLH from severe DHF. Early recognition and initiation of steroid treatment would be crucial for the successful treatment of dengue fever complicated by HLH.

KW - Corticosteroid

KW - Dengue hemorrhagic fever

KW - Hemophagocyticlymphohistiocytosis

KW - Severe dengue

UR - http://www.scopus.com/inward/record.url?scp=85015599555&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85015599555&partnerID=8YFLogxK

U2 - 10.1097/MD.0000000000006159

DO - 10.1097/MD.0000000000006159

M3 - Article

C2 - 28225498

AN - SCOPUS:85015599555

VL - 96

JO - Medicine; analytical reviews of general medicine, neurology, psychiatry, dermatology, and pediatries

JF - Medicine; analytical reviews of general medicine, neurology, psychiatry, dermatology, and pediatries

SN - 0025-7974

IS - 8

M1 - e6159

ER -