Depletion of ATP and release of presynaptic inhibition in the CA1 region of hippocampal slices during hypoglycemic hypoxia

Jong Hyun Kim, Jae Hak Kim, Joo Han Kim, Kyung Han Kim, Taek Hyun Kwon, Youn Kwan Park

    Research output: Contribution to journalArticlepeer-review

    4 Citations (Scopus)

    Abstract

    Transient recovery (TR) of evoked synaptic potentials and ATP depletion during the late stage of hypoxic hypoglycemic insults were investigated in rat hippocampal slices. TR was observed not only in the late stage of insult, but also during recovery. The concentration of ATP corresponded to the appearance (27% of control) and disappearance (15% of control) of TR. Paired pulse studies showed the presynaptic nature of the release of inhibition of synaptic transmission during TR. Both N- and P/Q-type voltage-dependent calcium channels were involved in the appearance of TR. This evidence suggests that underlying mechanisms of TR appearance during hypoxic hypoglycemic insult might be related to ATP depletion and release of A1 adenosine receptor mediated inhibition of presynaptic voltage-dependent calcium channels.

    Original languageEnglish
    Pages (from-to)56-60
    Number of pages5
    JournalNeuroscience Letters
    Volume411
    Issue number1
    DOIs
    Publication statusPublished - 2007 Jan 3

    Keywords

    • A1 adenosine receptor
    • Hypoglycemic hypoxia
    • Synaptic depression
    • Transient recovery
    • Voltage-dependent calcium channels

    ASJC Scopus subject areas

    • Neuroscience(all)

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