Abstract
Transient recovery (TR) of evoked synaptic potentials and ATP depletion during the late stage of hypoxic hypoglycemic insults were investigated in rat hippocampal slices. TR was observed not only in the late stage of insult, but also during recovery. The concentration of ATP corresponded to the appearance (27% of control) and disappearance (15% of control) of TR. Paired pulse studies showed the presynaptic nature of the release of inhibition of synaptic transmission during TR. Both N- and P/Q-type voltage-dependent calcium channels were involved in the appearance of TR. This evidence suggests that underlying mechanisms of TR appearance during hypoxic hypoglycemic insult might be related to ATP depletion and release of A1 adenosine receptor mediated inhibition of presynaptic voltage-dependent calcium channels.
| Original language | English |
|---|---|
| Pages (from-to) | 56-60 |
| Number of pages | 5 |
| Journal | Neuroscience Letters |
| Volume | 411 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2007 Jan 3 |
Fingerprint
Keywords
- A1 adenosine receptor
- Hypoglycemic hypoxia
- Synaptic depression
- Transient recovery
- Voltage-dependent calcium channels
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Depletion of ATP and release of presynaptic inhibition in the CA1 region of hippocampal slices during hypoglycemic hypoxia. / Kim, Jong Hyun; Kim, Jae Hak; Kim, Joo-Han; Kim, Kyung Han; Kwon, Taek-Hyun; Park, Youn-Kwan.
In: Neuroscience Letters, Vol. 411, No. 1, 03.01.2007, p. 56-60.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Depletion of ATP and release of presynaptic inhibition in the CA1 region of hippocampal slices during hypoglycemic hypoxia
AU - Kim, Jong Hyun
AU - Kim, Jae Hak
AU - Kim, Joo-Han
AU - Kim, Kyung Han
AU - Kwon, Taek-Hyun
AU - Park, Youn-Kwan
PY - 2007/1/3
Y1 - 2007/1/3
N2 - Transient recovery (TR) of evoked synaptic potentials and ATP depletion during the late stage of hypoxic hypoglycemic insults were investigated in rat hippocampal slices. TR was observed not only in the late stage of insult, but also during recovery. The concentration of ATP corresponded to the appearance (27% of control) and disappearance (15% of control) of TR. Paired pulse studies showed the presynaptic nature of the release of inhibition of synaptic transmission during TR. Both N- and P/Q-type voltage-dependent calcium channels were involved in the appearance of TR. This evidence suggests that underlying mechanisms of TR appearance during hypoxic hypoglycemic insult might be related to ATP depletion and release of A1 adenosine receptor mediated inhibition of presynaptic voltage-dependent calcium channels.
AB - Transient recovery (TR) of evoked synaptic potentials and ATP depletion during the late stage of hypoxic hypoglycemic insults were investigated in rat hippocampal slices. TR was observed not only in the late stage of insult, but also during recovery. The concentration of ATP corresponded to the appearance (27% of control) and disappearance (15% of control) of TR. Paired pulse studies showed the presynaptic nature of the release of inhibition of synaptic transmission during TR. Both N- and P/Q-type voltage-dependent calcium channels were involved in the appearance of TR. This evidence suggests that underlying mechanisms of TR appearance during hypoxic hypoglycemic insult might be related to ATP depletion and release of A1 adenosine receptor mediated inhibition of presynaptic voltage-dependent calcium channels.
KW - A1 adenosine receptor
KW - Hypoglycemic hypoxia
KW - Synaptic depression
KW - Transient recovery
KW - Voltage-dependent calcium channels
UR - http://www.scopus.com/inward/record.url?scp=33751000748&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33751000748&partnerID=8YFLogxK
U2 - 10.1016/j.neulet.2006.10.004
DO - 10.1016/j.neulet.2006.10.004
M3 - Article
C2 - 17095154
AN - SCOPUS:33751000748
VL - 411
SP - 56
EP - 60
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 1
ER -