Depletion of ATP and release of presynaptic inhibition in the CA1 region of hippocampal slices during hypoglycemic hypoxia

Jong Hyun Kim; Jae Hak Kim; Joo Han Kim; Kyung Han Kim; Taek Hyun Kwon; Youn Kwan Park

doi:10.1016/j.neulet.2006.10.004

Depletion of ATP and release of presynaptic inhibition in the CA1 region of hippocampal slices during hypoglycemic hypoxia

Jong Hyun Kim, Jae Hak Kim, Joo Han Kim, Kyung Han Kim, Taek Hyun Kwon, Youn Kwan Park

Department of Neurosurgery

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Transient recovery (TR) of evoked synaptic potentials and ATP depletion during the late stage of hypoxic hypoglycemic insults were investigated in rat hippocampal slices. TR was observed not only in the late stage of insult, but also during recovery. The concentration of ATP corresponded to the appearance (27% of control) and disappearance (15% of control) of TR. Paired pulse studies showed the presynaptic nature of the release of inhibition of synaptic transmission during TR. Both N- and P/Q-type voltage-dependent calcium channels were involved in the appearance of TR. This evidence suggests that underlying mechanisms of TR appearance during hypoxic hypoglycemic insult might be related to ATP depletion and release of A1 adenosine receptor mediated inhibition of presynaptic voltage-dependent calcium channels.

Original language	English
Pages (from-to)	56-60
Number of pages	5
Journal	Neuroscience Letters
Volume	411
Issue number	1
DOIs	https://doi.org/10.1016/j.neulet.2006.10.004
Publication status	Published - 2007 Jan 3

Keywords

A1 adenosine receptor
Hypoglycemic hypoxia
Synaptic depression
Transient recovery
Voltage-dependent calcium channels

ASJC Scopus subject areas

Neuroscience(all)

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title = "Depletion of ATP and release of presynaptic inhibition in the CA1 region of hippocampal slices during hypoglycemic hypoxia",

abstract = "Transient recovery (TR) of evoked synaptic potentials and ATP depletion during the late stage of hypoxic hypoglycemic insults were investigated in rat hippocampal slices. TR was observed not only in the late stage of insult, but also during recovery. The concentration of ATP corresponded to the appearance (27% of control) and disappearance (15% of control) of TR. Paired pulse studies showed the presynaptic nature of the release of inhibition of synaptic transmission during TR. Both N- and P/Q-type voltage-dependent calcium channels were involved in the appearance of TR. This evidence suggests that underlying mechanisms of TR appearance during hypoxic hypoglycemic insult might be related to ATP depletion and release of A1 adenosine receptor mediated inhibition of presynaptic voltage-dependent calcium channels.",

keywords = "A1 adenosine receptor, Hypoglycemic hypoxia, Synaptic depression, Transient recovery, Voltage-dependent calcium channels",

author = "Kim, {Jong Hyun} and Kim, {Jae Hak} and Kim, {Joo Han} and Kim, {Kyung Han} and Kwon, {Taek Hyun} and Park, {Youn Kwan}",

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T1 - Depletion of ATP and release of presynaptic inhibition in the CA1 region of hippocampal slices during hypoglycemic hypoxia

AU - Kim, Jong Hyun

AU - Kim, Jae Hak

AU - Kim, Joo Han

AU - Kim, Kyung Han

AU - Kwon, Taek Hyun

AU - Park, Youn Kwan

PY - 2007/1/3

Y1 - 2007/1/3

N2 - Transient recovery (TR) of evoked synaptic potentials and ATP depletion during the late stage of hypoxic hypoglycemic insults were investigated in rat hippocampal slices. TR was observed not only in the late stage of insult, but also during recovery. The concentration of ATP corresponded to the appearance (27% of control) and disappearance (15% of control) of TR. Paired pulse studies showed the presynaptic nature of the release of inhibition of synaptic transmission during TR. Both N- and P/Q-type voltage-dependent calcium channels were involved in the appearance of TR. This evidence suggests that underlying mechanisms of TR appearance during hypoxic hypoglycemic insult might be related to ATP depletion and release of A1 adenosine receptor mediated inhibition of presynaptic voltage-dependent calcium channels.

AB - Transient recovery (TR) of evoked synaptic potentials and ATP depletion during the late stage of hypoxic hypoglycemic insults were investigated in rat hippocampal slices. TR was observed not only in the late stage of insult, but also during recovery. The concentration of ATP corresponded to the appearance (27% of control) and disappearance (15% of control) of TR. Paired pulse studies showed the presynaptic nature of the release of inhibition of synaptic transmission during TR. Both N- and P/Q-type voltage-dependent calcium channels were involved in the appearance of TR. This evidence suggests that underlying mechanisms of TR appearance during hypoxic hypoglycemic insult might be related to ATP depletion and release of A1 adenosine receptor mediated inhibition of presynaptic voltage-dependent calcium channels.

KW - A1 adenosine receptor

KW - Hypoglycemic hypoxia

KW - Synaptic depression

KW - Transient recovery

KW - Voltage-dependent calcium channels

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