Depression among HIV-infected patients in Korea: Assessment of clinical significance and risk factors

Joon Young Song, Jin Soo Lee, Yu Bin Seo, In Seon Kim, Ji Youn Noh, Ji Hyeon Baek, Hee Jin Cheong, Woo Joo Kim

    Research output: Contribution to journalArticlepeer-review

    17 Citations (Scopus)

    Abstract

    Background: With prolonged life expectancies, mental illness has emerged as a disabling disorder among people with HIV. Materials and Methods: This study was conducted to assess the prevalence of depression and its risk factors among Korean patients with HIV infections. Eighty-two HIV-infected patients completed structured questionnaires including the Beck Depression Inventory and the State-Trait Anxiety Inventory. Subjects with depression were compared to those without depression in terms of demographics, comorbidities, CD4 T-cell count, RNA copy numbers, highly active antiretroviral therapy (HAART) regimens, and adherence. Results: The estimated depression rate was 21% (17 of 82 subjects). Comorbidities (47% vs. 20%, P = 0.01) and unemployment (65% vs. 31%, P = 0.02) were risk factors for depression. Depressive patients were more likely to be anxious (71% vs. 29%, P < 0.01), to frequently miss clinical appointments each year (P = 0.04), and to have higher cumulative time lost to follow-up per month (P <0.01) compared to non-depressive patients. Only three depressive patients were referred to neuropsychologists. Conclusions: More than 20% of the Korean HIV patients in this study suffered from depression associated with poor adherence. Considering the low level of recognition of depression by clinicians, risk factor-based active assessment is recommended to manage depression properly in HIV-infected patients.

    Original languageEnglish
    Pages (from-to)211-216
    Number of pages6
    JournalInfection and Chemotherapy
    Volume45
    Issue number2
    DOIs
    Publication statusPublished - 2013

    Keywords

    • Acquired immunodeficiency syndrome
    • Anxiety
    • Depression
    • HIV

    ASJC Scopus subject areas

    • Infectious Diseases
    • Pharmacology (medical)

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