Depression among HIV-infected patients in Korea: Assessment of clinical significance and risk factors

Joon Young Song, Jin Soo Lee, Yu Bin Seo, In Seon Kim, Ji Youn Noh, Ji Hyeon Baek, Hee Jin Cheong, Woo Joo Kim

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: With prolonged life expectancies, mental illness has emerged as a disabling disorder among people with HIV. Materials and Methods: This study was conducted to assess the prevalence of depression and its risk factors among Korean patients with HIV infections. Eighty-two HIV-infected patients completed structured questionnaires including the Beck Depression Inventory and the State-Trait Anxiety Inventory. Subjects with depression were compared to those without depression in terms of demographics, comorbidities, CD4 T-cell count, RNA copy numbers, highly active antiretroviral therapy (HAART) regimens, and adherence. Results: The estimated depression rate was 21% (17 of 82 subjects). Comorbidities (47% vs. 20%, P = 0.01) and unemployment (65% vs. 31%, P = 0.02) were risk factors for depression. Depressive patients were more likely to be anxious (71% vs. 29%, P < 0.01), to frequently miss clinical appointments each year (P = 0.04), and to have higher cumulative time lost to follow-up per month (P <0.01) compared to non-depressive patients. Only three depressive patients were referred to neuropsychologists. Conclusions: More than 20% of the Korean HIV patients in this study suffered from depression associated with poor adherence. Considering the low level of recognition of depression by clinicians, risk factor-based active assessment is recommended to manage depression properly in HIV-infected patients.

Original languageEnglish
Pages (from-to)211-216
Number of pages6
JournalInfection and Chemotherapy
Volume45
Issue number2
DOIs
Publication statusPublished - 2013

Keywords

  • Acquired immunodeficiency syndrome
  • Anxiety
  • Depression
  • HIV

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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