Depression and suicide risk prediction models using blood-derived multi-omics data

Youngjune Bhak, Hyoung oh Jeong, Yun Sung Cho, Sungwon Jeon, Juok Cho, Jeong An Gim, Yeonsu Jeon, Asta Blazyte, Seung Gu Park, Hak Min Kim, Eun Seok Shin, Jong Woo Paik, Hae Woo Lee, Wooyoung Kang, Aram Kim, Yumi Kim, Byung Chul Kim, Byung Joo Ham, Jong Bhak, Semin Lee

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1 Citation (Scopus)

Abstract

More than 300 million people worldwide experience depression; annually, ~800,000 people die by suicide. Unfortunately, conventional interview-based diagnosis is insufficient to accurately predict a psychiatric status. We developed machine learning models to predict depression and suicide risk using blood methylome and transcriptome data from 56 suicide attempters (SAs), 39 patients with major depressive disorder (MDD), and 87 healthy controls. Our random forest classifiers showed accuracies of 92.6% in distinguishing SAs from MDD patients, 87.3% in distinguishing MDD patients from controls, and 86.7% in distinguishing SAs from controls. We also developed regression models for predicting psychiatric scales with R2 values of 0.961 and 0.943 for Hamilton Rating Scale for Depression–17 and Scale for Suicide Ideation, respectively. Multi-omics data were used to construct psychiatric status prediction models for improved mental health treatment.

Original languageEnglish
Article number262
JournalTranslational psychiatry
Volume9
Issue number1
DOIs
Publication statusPublished - 2019 Dec 1

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience
  • Biological Psychiatry

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    Bhak, Y., Jeong, H. O., Cho, Y. S., Jeon, S., Cho, J., Gim, J. A., Jeon, Y., Blazyte, A., Park, S. G., Kim, H. M., Shin, E. S., Paik, J. W., Lee, H. W., Kang, W., Kim, A., Kim, Y., Kim, B. C., Ham, B. J., Bhak, J., & Lee, S. (2019). Depression and suicide risk prediction models using blood-derived multi-omics data. Translational psychiatry, 9(1), [262]. https://doi.org/10.1038/s41398-019-0595-2