Depression is associated with sarcopenia, not central obesity, in elderly Korean men

Nam Hoon Kim, Hye Sook Kim, Chai Ryoung Eun, Ji A Seo, Hyun Joo Cho, Sin Gon Kim, Kyung Mook Choi, Sei-Hyun Baik, Dong Seop Choi, Moon Ho Park, Changsu Han, Nan Hee Kim

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Objectives To examine the relationship between depression and various components of body composition, including fat and muscle, in elderly Koreans. Design A cross-sectional sample of a longitudinal cohort from the Ansan Geriatric (AGE) Study. Setting Elderly people living in urban area (Ansan City, South Korea). Participants Eight hundred thirty-six participants (378 male, 458 female) aged 60 and older were recruited from April 2006 to January 2008. Measurements Depressive symptoms were examined using the Korean version of the 30-item Geriatric Depression Scale (KGDS). Participants taking antidepressant medications or with a KGDS score of 14 or greater were classified as having depression. Abdominal visceral fat area (VFA) and subcutaneous fat area were assessed using single-slice computed tomography, and appendicular skeletal muscle mass (ASM) and percentage body fat (%BF) were determined using whole-body dual-energy X-ray absorptiometry. Results Elderly men with depression had a lower ASM than those without depression (P =.01) after adjusting for age, body weight, and height. In men, the risk of depression was lower with higher body mass index (BMI) (odds ratio (OR) per 1-standard deviation (SD) increase = 0.70, 95% confidence interval (CI) = 0.51-0.96) after adjusting for all confounding variables and higher ASM (OR per 1-SD increase = 0.49; 95% CI = 0.29-0.85) after controlling for age, height, and weight. Similarly, depression was negatively associated with BMI in women (OR per 1-SD increase = 0.73; 95% CI = 0.56-0.95). Waist circumference, %BF, and VFA were not consistently associated with depression in men or women. Conclusion Depression in elderly Koreans is associated with low body mass and sarcopenia, especially in men.

Original languageEnglish
Pages (from-to)2062-2068
Number of pages7
JournalJournal of the American Geriatrics Society
Volume59
Issue number11
DOIs
Publication statusPublished - 2011 Nov 1

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Sarcopenia
Abdominal Obesity
Depression
Skeletal Muscle
Intra-Abdominal Fat
Odds Ratio
Confidence Intervals
Geriatrics
Body Mass Index
Republic of Korea
Body Height
Confounding Factors (Epidemiology)
Subcutaneous Fat
Photon Absorptiometry
Waist Circumference
Body Composition
Antidepressive Agents
Adipose Tissue
Fats
Tomography

Keywords

  • body composition
  • depression
  • obesity
  • sarcopenia
  • skeletal muscle mass

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Depression is associated with sarcopenia, not central obesity, in elderly Korean men. / Kim, Nam Hoon; Kim, Hye Sook; Eun, Chai Ryoung; Seo, Ji A; Cho, Hyun Joo; Kim, Sin Gon; Choi, Kyung Mook; Baik, Sei-Hyun; Choi, Dong Seop; Park, Moon Ho; Han, Changsu; Kim, Nan Hee.

In: Journal of the American Geriatrics Society, Vol. 59, No. 11, 01.11.2011, p. 2062-2068.

Research output: Contribution to journalArticle

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title = "Depression is associated with sarcopenia, not central obesity, in elderly Korean men",
abstract = "Objectives To examine the relationship between depression and various components of body composition, including fat and muscle, in elderly Koreans. Design A cross-sectional sample of a longitudinal cohort from the Ansan Geriatric (AGE) Study. Setting Elderly people living in urban area (Ansan City, South Korea). Participants Eight hundred thirty-six participants (378 male, 458 female) aged 60 and older were recruited from April 2006 to January 2008. Measurements Depressive symptoms were examined using the Korean version of the 30-item Geriatric Depression Scale (KGDS). Participants taking antidepressant medications or with a KGDS score of 14 or greater were classified as having depression. Abdominal visceral fat area (VFA) and subcutaneous fat area were assessed using single-slice computed tomography, and appendicular skeletal muscle mass (ASM) and percentage body fat ({\%}BF) were determined using whole-body dual-energy X-ray absorptiometry. Results Elderly men with depression had a lower ASM than those without depression (P =.01) after adjusting for age, body weight, and height. In men, the risk of depression was lower with higher body mass index (BMI) (odds ratio (OR) per 1-standard deviation (SD) increase = 0.70, 95{\%} confidence interval (CI) = 0.51-0.96) after adjusting for all confounding variables and higher ASM (OR per 1-SD increase = 0.49; 95{\%} CI = 0.29-0.85) after controlling for age, height, and weight. Similarly, depression was negatively associated with BMI in women (OR per 1-SD increase = 0.73; 95{\%} CI = 0.56-0.95). Waist circumference, {\%}BF, and VFA were not consistently associated with depression in men or women. Conclusion Depression in elderly Koreans is associated with low body mass and sarcopenia, especially in men.",
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T1 - Depression is associated with sarcopenia, not central obesity, in elderly Korean men

AU - Kim, Nam Hoon

AU - Kim, Hye Sook

AU - Eun, Chai Ryoung

AU - Seo, Ji A

AU - Cho, Hyun Joo

AU - Kim, Sin Gon

AU - Choi, Kyung Mook

AU - Baik, Sei-Hyun

AU - Choi, Dong Seop

AU - Park, Moon Ho

AU - Han, Changsu

AU - Kim, Nan Hee

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N2 - Objectives To examine the relationship between depression and various components of body composition, including fat and muscle, in elderly Koreans. Design A cross-sectional sample of a longitudinal cohort from the Ansan Geriatric (AGE) Study. Setting Elderly people living in urban area (Ansan City, South Korea). Participants Eight hundred thirty-six participants (378 male, 458 female) aged 60 and older were recruited from April 2006 to January 2008. Measurements Depressive symptoms were examined using the Korean version of the 30-item Geriatric Depression Scale (KGDS). Participants taking antidepressant medications or with a KGDS score of 14 or greater were classified as having depression. Abdominal visceral fat area (VFA) and subcutaneous fat area were assessed using single-slice computed tomography, and appendicular skeletal muscle mass (ASM) and percentage body fat (%BF) were determined using whole-body dual-energy X-ray absorptiometry. Results Elderly men with depression had a lower ASM than those without depression (P =.01) after adjusting for age, body weight, and height. In men, the risk of depression was lower with higher body mass index (BMI) (odds ratio (OR) per 1-standard deviation (SD) increase = 0.70, 95% confidence interval (CI) = 0.51-0.96) after adjusting for all confounding variables and higher ASM (OR per 1-SD increase = 0.49; 95% CI = 0.29-0.85) after controlling for age, height, and weight. Similarly, depression was negatively associated with BMI in women (OR per 1-SD increase = 0.73; 95% CI = 0.56-0.95). Waist circumference, %BF, and VFA were not consistently associated with depression in men or women. Conclusion Depression in elderly Koreans is associated with low body mass and sarcopenia, especially in men.

AB - Objectives To examine the relationship between depression and various components of body composition, including fat and muscle, in elderly Koreans. Design A cross-sectional sample of a longitudinal cohort from the Ansan Geriatric (AGE) Study. Setting Elderly people living in urban area (Ansan City, South Korea). Participants Eight hundred thirty-six participants (378 male, 458 female) aged 60 and older were recruited from April 2006 to January 2008. Measurements Depressive symptoms were examined using the Korean version of the 30-item Geriatric Depression Scale (KGDS). Participants taking antidepressant medications or with a KGDS score of 14 or greater were classified as having depression. Abdominal visceral fat area (VFA) and subcutaneous fat area were assessed using single-slice computed tomography, and appendicular skeletal muscle mass (ASM) and percentage body fat (%BF) were determined using whole-body dual-energy X-ray absorptiometry. Results Elderly men with depression had a lower ASM than those without depression (P =.01) after adjusting for age, body weight, and height. In men, the risk of depression was lower with higher body mass index (BMI) (odds ratio (OR) per 1-standard deviation (SD) increase = 0.70, 95% confidence interval (CI) = 0.51-0.96) after adjusting for all confounding variables and higher ASM (OR per 1-SD increase = 0.49; 95% CI = 0.29-0.85) after controlling for age, height, and weight. Similarly, depression was negatively associated with BMI in women (OR per 1-SD increase = 0.73; 95% CI = 0.56-0.95). Waist circumference, %BF, and VFA were not consistently associated with depression in men or women. Conclusion Depression in elderly Koreans is associated with low body mass and sarcopenia, especially in men.

KW - body composition

KW - depression

KW - obesity

KW - sarcopenia

KW - skeletal muscle mass

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