Depth-dependent cerebral hemodynamic responses following Direct Cortical Electrical Stimulation (DCES) revealed by in vivo dualoptical imaging techniques

Seungduk Lee, Dalkwon Koh, Areum Jo, Hae Young Lim, Young Jin Jung, Choong Ki Kim, Youngwook Seo, Chang Hwan Im, Beop-Min Kim, Minah Suh

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

We studied depth-dependent cerebral hemodynamic responses of rat brain following direct cortical electrical stimulation (DCES) in vivo with optical recording of intrinsic signal (ORIS) and near-infrared spectroscopy (NIRS). ORIS is used to visualize the immediate hemodynamic changes in cortical areas following the stimulation, whereas NIRS measures the hemodynamic changes originating from subcortical areas. We found strong hemodynamic changes in relation to DCES both in ORIS and NIRS data. In particular, the signals originating from cortical areas exhibited a tri-phasic response, whereas those originating from subcortical regions exhibited multi-phasic responses. In addition, NIRS signals from two different sets of source-detector separation were compared and analyzed to investigate the causality of perfusion, which demonstrated downstream propagation, indicating that the upper brain region reacted faster than the deep region.

Original languageEnglish
Pages (from-to)6932-6943
Number of pages12
JournalOptics Express
Volume20
Issue number7
DOIs
Publication statusPublished - 2012 Mar 26

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hemodynamic responses
stimulation
imaging techniques
hemodynamics
infrared spectroscopy
recording
brain
rats
propagation
detectors

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

Cite this

Depth-dependent cerebral hemodynamic responses following Direct Cortical Electrical Stimulation (DCES) revealed by in vivo dualoptical imaging techniques. / Lee, Seungduk; Koh, Dalkwon; Jo, Areum; Lim, Hae Young; Jung, Young Jin; Kim, Choong Ki; Seo, Youngwook; Im, Chang Hwan; Kim, Beop-Min; Suh, Minah.

In: Optics Express, Vol. 20, No. 7, 26.03.2012, p. 6932-6943.

Research output: Contribution to journalArticle

Lee, Seungduk ; Koh, Dalkwon ; Jo, Areum ; Lim, Hae Young ; Jung, Young Jin ; Kim, Choong Ki ; Seo, Youngwook ; Im, Chang Hwan ; Kim, Beop-Min ; Suh, Minah. / Depth-dependent cerebral hemodynamic responses following Direct Cortical Electrical Stimulation (DCES) revealed by in vivo dualoptical imaging techniques. In: Optics Express. 2012 ; Vol. 20, No. 7. pp. 6932-6943.
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