Derivation of functional dopamine neurons from embryonic stem cells

Dae Sung Kim, Ji Young Kim, Minkyung Kang, Myung Soo Cho, Dong Wook Kim

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26 Citations (Scopus)

Abstract

Parkinson's disease (PD) is a neurodegenerative disorder characterized by the selective degeneration of dopaminergic (DA) neurons in the substantia nigra of the midbrain. Pharmacological treatment of PD has been a prevailing strategy. However, it has some limitations because its effectiveness gradually decreases and side effects develop. As an alternative, cell transplantation therapy has been tried. Although transplantation of fetal ventral mesencephalic cells looks promising for the treatment of PD in some cases, ethical and technical problems in obtaining large numbers of human fetal brain tissues also lead to difficulty in its clinical application. Our recent studies showed that a high yield of DA neurons could be derived from embryonic stem (ES) cells and they efficiently induced behavioral recovery in a PD animal model. Here we summarize methods for generation of functional DA neurons from ES cells for application to PD models.

Original languageEnglish
Pages (from-to)117-123
Number of pages7
JournalCell Transplantation
Volume16
Issue number2
Publication statusPublished - 2007 May 4
Externally publishedYes

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Keywords

  • Dopamine neurons
  • Embryonic stem cells
  • Parkinson's disease

ASJC Scopus subject areas

  • Biomedical Engineering
  • Cell Biology
  • Transplantation

Cite this

Kim, D. S., Kim, J. Y., Kang, M., Cho, M. S., & Kim, D. W. (2007). Derivation of functional dopamine neurons from embryonic stem cells. Cell Transplantation, 16(2), 117-123.