Design and Rationale of the Intima-Medial Thickness Sub-Study of the PreventIon of CArdiovascular Events in iSchemic Stroke Patients with High Risk of Cerebral hemOrrhage (PICASSO-IMT) Study

PICASSO Investigators

Research output: Contribution to journalArticle

Abstract

Background Atherosclerosis is one of the main mechanisms of stroke and cardiovascular diseases and is associated with increased risk of recurrent stroke and cardiovascular events. Intima-medial thickness (IMT) is a well-known surrogate marker of atherosclerosis and has been used to predict stroke and cardiovascular events. However, the clinical significance of IMT and IMT change in stroke has not been investigated in well-designed studies. The PreventIon of CArdiovascular events in iSchemic Stroke patients with high risk of cerebral hemOrrhage—Intima-Media Thickness (PICASSO-IMT) sub-study is designed to investigate the effects of cilostazol, probucol, or both on IMT in patients with stroke. Methods PICASSO-IMT is a prospective sub-study of the PICASSO study designed to measure IMT and plaque score at 1, 13, 25, 37, and 49 months after randomization. Results The primary outcome is the change in mean carotid IMT, which is defined as the mean of the far-wall IMTs of the right and left common carotid arteries, between baseline and 13 months after randomization. Conclusion PICASSO-IMT will provide the largest IMT data set in a stroke population and will provide valuable information about the clinical significance of IMT in patients with ischemic stroke.

Original languageEnglish
Pages (from-to)1892-1898
Number of pages7
JournalJournal of Stroke and Cerebrovascular Diseases
Volume26
Issue number9
DOIs
Publication statusPublished - 2017 Sep 1

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Cerebral Hemorrhage
Stroke
Random Allocation
Atherosclerosis
Myocardial Infarction
Probucol
Common Carotid Artery
Cardiovascular Diseases
Biomarkers
Prospective Studies
Population

Keywords

  • atherosclerosis
  • Intima-medial thickness
  • ischemic stroke
  • randomized clinical trial
  • recurrence

ASJC Scopus subject areas

  • Surgery
  • Rehabilitation
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

@article{cca3e09887f3496cbb8522971bbc6aa6,
title = "Design and Rationale of the Intima-Medial Thickness Sub-Study of the PreventIon of CArdiovascular Events in iSchemic Stroke Patients with High Risk of Cerebral hemOrrhage (PICASSO-IMT) Study",
abstract = "Background Atherosclerosis is one of the main mechanisms of stroke and cardiovascular diseases and is associated with increased risk of recurrent stroke and cardiovascular events. Intima-medial thickness (IMT) is a well-known surrogate marker of atherosclerosis and has been used to predict stroke and cardiovascular events. However, the clinical significance of IMT and IMT change in stroke has not been investigated in well-designed studies. The PreventIon of CArdiovascular events in iSchemic Stroke patients with high risk of cerebral hemOrrhage—Intima-Media Thickness (PICASSO-IMT) sub-study is designed to investigate the effects of cilostazol, probucol, or both on IMT in patients with stroke. Methods PICASSO-IMT is a prospective sub-study of the PICASSO study designed to measure IMT and plaque score at 1, 13, 25, 37, and 49 months after randomization. Results The primary outcome is the change in mean carotid IMT, which is defined as the mean of the far-wall IMTs of the right and left common carotid arteries, between baseline and 13 months after randomization. Conclusion PICASSO-IMT will provide the largest IMT data set in a stroke population and will provide valuable information about the clinical significance of IMT in patients with ischemic stroke.",
keywords = "atherosclerosis, Intima-medial thickness, ischemic stroke, randomized clinical trial, recurrence",
author = "{PICASSO Investigators} and Kwon, {S. U.} and Kwon, {S. U.} and Lee, {J. Y.} and Kyung-Hee Cho and Jin-Man Jung and Kim, {Y. J.} and Kim, {Y. J.} and Seo, {W. K.} and Seo, {W. K.} and Lee, {S. H.} and Lee, {Y. S.} and Kim, {D. E.} and Lee, {J. H.} and Rha, {J. H.} and Park, {K. Y.} and Heo, {S. H.} and Kim, {H. Y.} and Kim, {Y. D.} and Cho, {A. H.} and Baik, {J. S.} and Lee, {J. S.} and Lee, {J. Y.} and J. Park and Park, {T. H.} and Kim, {E. G.} and Koh, {I. S.} and Cha, {J. K.} and Choi, {N. C.} and Kwon, {J. H.} and Sohn, {S. I.} and J. Lee and Hwang, {Y. H.} and Song, {H. J.} and Shin, {B. S.} and Sin, {D. I.} and Kim, {J. T.} and Lee, {S. J.} and Park, {H. Y.} and Ahn, {S. H.} and Chung, {P. W.} and Kwon, {S. B.} and Lee, {J. H.} and Do, {J. K.} and Lee, {S. B.} and Lee, {Y. B.} and Yoo, {B. G.} and Sung, {S. M.} and O. Kim and Lee, {K. Y.} and Juneyoung Lee",
year = "2017",
month = "9",
day = "1",
doi = "10.1016/j.jstrokecerebrovasdis.2017.06.035",
language = "English",
volume = "26",
pages = "1892--1898",
journal = "Journal of Stroke and Cerebrovascular Diseases",
issn = "1052-3057",
publisher = "W.B. Saunders Ltd",
number = "9",

}

TY - JOUR

T1 - Design and Rationale of the Intima-Medial Thickness Sub-Study of the PreventIon of CArdiovascular Events in iSchemic Stroke Patients with High Risk of Cerebral hemOrrhage (PICASSO-IMT) Study

AU - PICASSO Investigators

AU - Kwon, S. U.

AU - Kwon, S. U.

AU - Lee, J. Y.

AU - Cho, Kyung-Hee

AU - Jung, Jin-Man

AU - Kim, Y. J.

AU - Kim, Y. J.

AU - Seo, W. K.

AU - Seo, W. K.

AU - Lee, S. H.

AU - Lee, Y. S.

AU - Kim, D. E.

AU - Lee, J. H.

AU - Rha, J. H.

AU - Park, K. Y.

AU - Heo, S. H.

AU - Kim, H. Y.

AU - Kim, Y. D.

AU - Cho, A. H.

AU - Baik, J. S.

AU - Lee, J. S.

AU - Lee, J. Y.

AU - Park, J.

AU - Park, T. H.

AU - Kim, E. G.

AU - Koh, I. S.

AU - Cha, J. K.

AU - Choi, N. C.

AU - Kwon, J. H.

AU - Sohn, S. I.

AU - Lee, J.

AU - Hwang, Y. H.

AU - Song, H. J.

AU - Shin, B. S.

AU - Sin, D. I.

AU - Kim, J. T.

AU - Lee, S. J.

AU - Park, H. Y.

AU - Ahn, S. H.

AU - Chung, P. W.

AU - Kwon, S. B.

AU - Lee, J. H.

AU - Do, J. K.

AU - Lee, S. B.

AU - Lee, Y. B.

AU - Yoo, B. G.

AU - Sung, S. M.

AU - Kim, O.

AU - Lee, K. Y.

AU - Lee, Juneyoung

PY - 2017/9/1

Y1 - 2017/9/1

N2 - Background Atherosclerosis is one of the main mechanisms of stroke and cardiovascular diseases and is associated with increased risk of recurrent stroke and cardiovascular events. Intima-medial thickness (IMT) is a well-known surrogate marker of atherosclerosis and has been used to predict stroke and cardiovascular events. However, the clinical significance of IMT and IMT change in stroke has not been investigated in well-designed studies. The PreventIon of CArdiovascular events in iSchemic Stroke patients with high risk of cerebral hemOrrhage—Intima-Media Thickness (PICASSO-IMT) sub-study is designed to investigate the effects of cilostazol, probucol, or both on IMT in patients with stroke. Methods PICASSO-IMT is a prospective sub-study of the PICASSO study designed to measure IMT and plaque score at 1, 13, 25, 37, and 49 months after randomization. Results The primary outcome is the change in mean carotid IMT, which is defined as the mean of the far-wall IMTs of the right and left common carotid arteries, between baseline and 13 months after randomization. Conclusion PICASSO-IMT will provide the largest IMT data set in a stroke population and will provide valuable information about the clinical significance of IMT in patients with ischemic stroke.

AB - Background Atherosclerosis is one of the main mechanisms of stroke and cardiovascular diseases and is associated with increased risk of recurrent stroke and cardiovascular events. Intima-medial thickness (IMT) is a well-known surrogate marker of atherosclerosis and has been used to predict stroke and cardiovascular events. However, the clinical significance of IMT and IMT change in stroke has not been investigated in well-designed studies. The PreventIon of CArdiovascular events in iSchemic Stroke patients with high risk of cerebral hemOrrhage—Intima-Media Thickness (PICASSO-IMT) sub-study is designed to investigate the effects of cilostazol, probucol, or both on IMT in patients with stroke. Methods PICASSO-IMT is a prospective sub-study of the PICASSO study designed to measure IMT and plaque score at 1, 13, 25, 37, and 49 months after randomization. Results The primary outcome is the change in mean carotid IMT, which is defined as the mean of the far-wall IMTs of the right and left common carotid arteries, between baseline and 13 months after randomization. Conclusion PICASSO-IMT will provide the largest IMT data set in a stroke population and will provide valuable information about the clinical significance of IMT in patients with ischemic stroke.

KW - atherosclerosis

KW - Intima-medial thickness

KW - ischemic stroke

KW - randomized clinical trial

KW - recurrence

UR - http://www.scopus.com/inward/record.url?scp=85025148191&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85025148191&partnerID=8YFLogxK

U2 - 10.1016/j.jstrokecerebrovasdis.2017.06.035

DO - 10.1016/j.jstrokecerebrovasdis.2017.06.035

M3 - Article

VL - 26

SP - 1892

EP - 1898

JO - Journal of Stroke and Cerebrovascular Diseases

JF - Journal of Stroke and Cerebrovascular Diseases

SN - 1052-3057

IS - 9

ER -