Design and syntheses of 2-oxiranecarboxylate derivatives and their hypoglycemic activities

Sang Sup Jew, Eun Kyung Kim, Sun Mi Je, Long Xuan Zhao, Hyung Ook Kim, Hyeung Geun Park, Kwang Ho Ko, Won Ki Kim, Hwa Jung Kim, Jae Hoon Cheong, Eung Seok Lee

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

A series of 2-oxiranecarboxylate derivatives were prepared as carnitine palmitoyl transferase I (CPT-I) inhibitors for the development of new antidiabetic agents. The syntheses and biological activities were reported. The most promising derivative (13b) showed 2.5 times more hypoglycemic activity and 2 times lower acute toxicity compared to Etomoxir (3).

Original languageEnglish
Pages (from-to)1087-1103
Number of pages17
JournalHeterocycles
Volume52
Issue number3
DOIs
Publication statusPublished - 2000 Mar 1
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Design and syntheses of 2-oxiranecarboxylate derivatives and their hypoglycemic activities'. Together they form a unique fingerprint.

Cite this