Design and syntheses of 2-oxiranecarboxylate derivatives and their hypoglycemic activities

Sang Sup Jew, Eun Kyung Kim, Sun Mi Je, Long Xuan Zhao, Hyung Ook Kim, Hyeung Geun Park, Kwang Ho Ko, Won-Ki Kim, Hwa Jung Kim, Jae Hoon Cheong, Eung Seok Lee

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4 Citations (Scopus)

Abstract

A series of 2-oxiranecarboxylate derivatives were prepared as carnitine palmitoyl transferase I (CPT-I) inhibitors for the development of new antidiabetic agents. The syntheses and biological activities were reported. The most promising derivative (13b) showed 2.5 times more hypoglycemic activity and 2 times lower acute toxicity compared to Etomoxir (3).

Original languageEnglish
Pages (from-to)1087-1103
Number of pages17
JournalHeterocycles
Volume52
Issue number3
Publication statusPublished - 2000 Mar 1
Externally publishedYes

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ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Jew, S. S., Kim, E. K., Je, S. M., Zhao, L. X., Kim, H. O., Park, H. G., Ko, K. H., Kim, W-K., Kim, H. J., Cheong, J. H., & Lee, E. S. (2000). Design and syntheses of 2-oxiranecarboxylate derivatives and their hypoglycemic activities. Heterocycles, 52(3), 1087-1103.