Design and syntheses of 2-oxiranecarboxylate derivatives and their hypoglycemic activities

Sang Sup Jew, Eun Kyung Kim, Sun Mi Je, Long Xuan Zhao, Hyung Ook Kim, Hyeung Geun Park, Kwang Ho Ko, Won-Ki Kim, Hwa Jung Kim, Jae Hoon Cheong, Eung Seok Lee

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A series of 2-oxiranecarboxylate derivatives were prepared as carnitine palmitoyl transferase I (CPT-I) inhibitors for the development of new antidiabetic agents. The syntheses and biological activities were reported. The most promising derivative (13b) showed 2.5 times more hypoglycemic activity and 2 times lower acute toxicity compared to Etomoxir (3).

Original languageEnglish
Pages (from-to)1087-1103
Number of pages17
JournalHeterocycles
Volume52
Issue number3
Publication statusPublished - 2000 Mar 1
Externally publishedYes

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Hypoglycemic Agents
Derivatives
Carnitine
Transferases
Bioactivity
Toxicity
etomoxir

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Jew, S. S., Kim, E. K., Je, S. M., Zhao, L. X., Kim, H. O., Park, H. G., ... Lee, E. S. (2000). Design and syntheses of 2-oxiranecarboxylate derivatives and their hypoglycemic activities. Heterocycles, 52(3), 1087-1103.

Design and syntheses of 2-oxiranecarboxylate derivatives and their hypoglycemic activities. / Jew, Sang Sup; Kim, Eun Kyung; Je, Sun Mi; Zhao, Long Xuan; Kim, Hyung Ook; Park, Hyeung Geun; Ko, Kwang Ho; Kim, Won-Ki; Kim, Hwa Jung; Cheong, Jae Hoon; Lee, Eung Seok.

In: Heterocycles, Vol. 52, No. 3, 01.03.2000, p. 1087-1103.

Research output: Contribution to journalArticle

Jew, SS, Kim, EK, Je, SM, Zhao, LX, Kim, HO, Park, HG, Ko, KH, Kim, W-K, Kim, HJ, Cheong, JH & Lee, ES 2000, 'Design and syntheses of 2-oxiranecarboxylate derivatives and their hypoglycemic activities', Heterocycles, vol. 52, no. 3, pp. 1087-1103.
Jew SS, Kim EK, Je SM, Zhao LX, Kim HO, Park HG et al. Design and syntheses of 2-oxiranecarboxylate derivatives and their hypoglycemic activities. Heterocycles. 2000 Mar 1;52(3):1087-1103.
Jew, Sang Sup ; Kim, Eun Kyung ; Je, Sun Mi ; Zhao, Long Xuan ; Kim, Hyung Ook ; Park, Hyeung Geun ; Ko, Kwang Ho ; Kim, Won-Ki ; Kim, Hwa Jung ; Cheong, Jae Hoon ; Lee, Eung Seok. / Design and syntheses of 2-oxiranecarboxylate derivatives and their hypoglycemic activities. In: Heterocycles. 2000 ; Vol. 52, No. 3. pp. 1087-1103.
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