Design and synthesis of biofunctionalized metallic/magnetic nanomaterials

Eun Kyung Lim, Seungjoo Haam, Kwangyeol Lee, Yong Min Huh

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

Organic solvent-soluble nanocrystals suitable for magnetic resonance imaging are prepared by two routes, namely, a coprecipitation method and a multiple-step thermal decomposition method (seed-mediated growth). The size, shape, crystallinity, phase, and composition of the prepared nanocrystals are determined by various characterization techniques, including transmission electron microscopy, vibratingsample magnetometer, X-ray diffraction, and inductively coupled plasma mass spectroscopy. Subsequently, the organic-soluble nanocrystals are rendered water-soluble by two methods, the microemulsion method and the ligand exchange method, for biomedical applications. Detailed protocols for the preparation of water-soluble nanocrystals, as well as procedures for drug-loading and antibody conjugation to the water-soluble nanocrystals are provided.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages583-595
Number of pages13
DOIs
Publication statusPublished - 2011

Publication series

NameMethods in Molecular Biology
Volume751
ISSN (Print)1064-3745

Keywords

  • Antibody
  • Coprecipitation
  • Drug
  • Ligand exchange
  • Magnetic nanocrystals
  • Magnetic nanoparticles
  • Microemulsion
  • Seed-mediated growth

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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  • Cite this

    Lim, E. K., Haam, S., Lee, K., & Huh, Y. M. (2011). Design and synthesis of biofunctionalized metallic/magnetic nanomaterials. In Methods in Molecular Biology (pp. 583-595). (Methods in Molecular Biology; Vol. 751). Humana Press Inc.. https://doi.org/10.1007/978-1-61779-151-2_36