Design and synthesis of biofunctionalized metallic/magnetic nanomaterials.

Eun Kyung Lim, Seungjoo Haam, Kwangyeol Lee, Yong Min Huh

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Organic solvent-soluble nanocrystals suitable for magnetic resonance imaging are prepared by two routes, namely, a coprecipitation method and a multiple-step thermal decomposition method (seed-mediated growth). The size, shape, crystallinity, phase, and composition of the prepared nanocrystals are determined by various characterization techniques, including transmission electron microscopy, vibrating-sample magnetometer, X-ray diffraction, and inductively coupled plasma mass spectroscopy. Subsequently, the organic-soluble nanocrystals are rendered water-soluble by two methods, the microemulsion method and the ligand exchange method, for biomedical applications. Detailed protocols for the preparation of water-soluble nanocrystals, as well as procedures for drug-loading and antibody conjugation to the water-soluble nanocrystals are provided.

Original languageEnglish
Pages (from-to)583-595
Number of pages13
JournalMethods in molecular biology (Clifton, N.J.)
Volume751
Publication statusPublished - 2011 Oct 4

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Nanostructures
Nanoparticles
Water
Transmission Electron Microscopy
X-Ray Diffraction
Mass Spectrometry
Seeds
Hot Temperature
Magnetic Resonance Imaging
Ligands
Antibodies
Growth
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Design and synthesis of biofunctionalized metallic/magnetic nanomaterials. / Lim, Eun Kyung; Haam, Seungjoo; Lee, Kwangyeol; Huh, Yong Min.

In: Methods in molecular biology (Clifton, N.J.), Vol. 751, 04.10.2011, p. 583-595.

Research output: Contribution to journalArticle

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