Abstract
Organic solvent-soluble nanocrystals suitable for magnetic resonance imaging are prepared by two routes, namely, a coprecipitation method and a multiple-step thermal decomposition method (seed-mediated growth). The size, shape, crystallinity, phase, and composition of the prepared nanocrystals are determined by various characterization techniques, including transmission electron microscopy, vibrating-sample magnetometer, X-ray diffraction, and inductively coupled plasma mass spectroscopy. Subsequently, the organic-soluble nanocrystals are rendered water-soluble by two methods, the microemulsion method and the ligand exchange method, for biomedical applications. Detailed protocols for the preparation of water-soluble nanocrystals, as well as procedures for drug-loading and antibody conjugation to the water-soluble nanocrystals are provided.
| Original language | English |
|---|---|
| Pages (from-to) | 583-595 |
| Number of pages | 13 |
| Journal | Methods in molecular biology (Clifton, N.J.) |
| Volume | 751 |
| Publication status | Published - 2011 Oct 4 |
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ASJC Scopus subject areas
- Medicine(all)
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Design and synthesis of biofunctionalized metallic/magnetic nanomaterials. / Lim, Eun Kyung; Haam, Seungjoo; Lee, Kwangyeol; Huh, Yong Min.
In: Methods in molecular biology (Clifton, N.J.), Vol. 751, 04.10.2011, p. 583-595.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Design and synthesis of biofunctionalized metallic/magnetic nanomaterials.
AU - Lim, Eun Kyung
AU - Haam, Seungjoo
AU - Lee, Kwangyeol
AU - Huh, Yong Min
PY - 2011/10/4
Y1 - 2011/10/4
N2 - Organic solvent-soluble nanocrystals suitable for magnetic resonance imaging are prepared by two routes, namely, a coprecipitation method and a multiple-step thermal decomposition method (seed-mediated growth). The size, shape, crystallinity, phase, and composition of the prepared nanocrystals are determined by various characterization techniques, including transmission electron microscopy, vibrating-sample magnetometer, X-ray diffraction, and inductively coupled plasma mass spectroscopy. Subsequently, the organic-soluble nanocrystals are rendered water-soluble by two methods, the microemulsion method and the ligand exchange method, for biomedical applications. Detailed protocols for the preparation of water-soluble nanocrystals, as well as procedures for drug-loading and antibody conjugation to the water-soluble nanocrystals are provided.
AB - Organic solvent-soluble nanocrystals suitable for magnetic resonance imaging are prepared by two routes, namely, a coprecipitation method and a multiple-step thermal decomposition method (seed-mediated growth). The size, shape, crystallinity, phase, and composition of the prepared nanocrystals are determined by various characterization techniques, including transmission electron microscopy, vibrating-sample magnetometer, X-ray diffraction, and inductively coupled plasma mass spectroscopy. Subsequently, the organic-soluble nanocrystals are rendered water-soluble by two methods, the microemulsion method and the ligand exchange method, for biomedical applications. Detailed protocols for the preparation of water-soluble nanocrystals, as well as procedures for drug-loading and antibody conjugation to the water-soluble nanocrystals are provided.
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UR - http://www.scopus.com/inward/citedby.url?scp=80053296434&partnerID=8YFLogxK
M3 - Article
C2 - 21674356
AN - SCOPUS:80053296434
VL - 751
SP - 583
EP - 595
JO - Methods in Molecular Biology
JF - Methods in Molecular Biology
SN - 1064-3745
ER -