Design, development, and evaluation of a novel microneedle array-based continuous glucose monitor

Arvind Jina, Michael J. Tierney, Janet A. Tamada, Scott McGill, Shashi Desai, Beelee Chua, Anna Chang, Mark Christiansen

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

The development of accurate, minimally invasive continuous glucose monitoring (CGM) devices has been the subject of much work by several groups, as it is believed that a less invasive and more user-friendly device will result in greater adoption of CGM by persons with insulin-dependent diabetes. This article presents the results of preliminary clinical studies in subjects with diabetes of a novel prototype microneedle-based continuous glucose monitor. In this device, an array of tiny hollow microneedles is applied into the epidermis from where glucose in interstitial fluid (ISF) is transported via passive diffusion to an amperometric glucose sensor external to the body. Comparison of 1396 paired device glucose measurements and fingerstick blood glucose readings for up to 72-hour wear in 10 diabetic subjects shows the device to be accurate and well tolerated by the subjects. Overall mean absolute relative difference (MARD) is 15% with 98.4% of paired points in the A+B region of the Clarke error grid. The prototype device has demonstrated clinically accurate glucose readings over 72 hours, the first time a microneedle-based device has achieved such performance.

Original languageEnglish
Pages (from-to)483-487
Number of pages5
JournalJournal of diabetes science and technology
Volume8
Issue number3
DOIs
Publication statusPublished - 2014 Jan 1
Externally publishedYes

Fingerprint

Glucose
Equipment and Supplies
Medical problems
Reading
Amperometric sensors
Glucose sensors
Monitoring
Matched-Pair Analysis
Insulin
Extracellular Fluid
Blood Glucose
Epidermis
Wear of materials
Blood
Fluids

Keywords

  • Continuous glucose
  • Interstitial fluid
  • Microneedle
  • Minimally invasive

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine
  • Bioengineering
  • Biomedical Engineering

Cite this

Jina, A., Tierney, M. J., Tamada, J. A., McGill, S., Desai, S., Chua, B., ... Christiansen, M. (2014). Design, development, and evaluation of a novel microneedle array-based continuous glucose monitor. Journal of diabetes science and technology, 8(3), 483-487. https://doi.org/10.1177/1932296814526191

Design, development, and evaluation of a novel microneedle array-based continuous glucose monitor. / Jina, Arvind; Tierney, Michael J.; Tamada, Janet A.; McGill, Scott; Desai, Shashi; Chua, Beelee; Chang, Anna; Christiansen, Mark.

In: Journal of diabetes science and technology, Vol. 8, No. 3, 01.01.2014, p. 483-487.

Research output: Contribution to journalArticle

Jina, A, Tierney, MJ, Tamada, JA, McGill, S, Desai, S, Chua, B, Chang, A & Christiansen, M 2014, 'Design, development, and evaluation of a novel microneedle array-based continuous glucose monitor', Journal of diabetes science and technology, vol. 8, no. 3, pp. 483-487. https://doi.org/10.1177/1932296814526191
Jina, Arvind ; Tierney, Michael J. ; Tamada, Janet A. ; McGill, Scott ; Desai, Shashi ; Chua, Beelee ; Chang, Anna ; Christiansen, Mark. / Design, development, and evaluation of a novel microneedle array-based continuous glucose monitor. In: Journal of diabetes science and technology. 2014 ; Vol. 8, No. 3. pp. 483-487.
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