Design, fabrication, and packaging of an integrated, wirelessly-powered optrode array for optogenetics application

Ki Yong Kwon, Hyung Min Lee, Maysam Ghovanloo, Arthur Weber, Wen Li

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

The recent development of optogenetics has created an increased demand for advancing engineering tools for optical modulation of neural circuitry. This paper details the design, fabrication, integration, and packaging procedures of a wirelessly-powered, light emitting diode (LED) coupled optrode neural interface for optogenetic studies. The LED-coupled optrode array employs microscale LED (μLED) chips and polymer-based microwaveguides to deliver light into multi-level cortical networks, coupled with microelectrodes to record spontaneous changes in neural activity. An integrated, implantable, switched-capacitor based stimulator (SCS) system provides high instantaneous power to the μLEDs through an inductive link to emit sufficient light and evoke neural activities. The presented system is mechanically flexible, biocompatible, miniaturized, and lightweight, suitable for chronic implantation in small freely behaving animals. The design of this system is scalable and its manufacturing is cost effective through batch fabrication using microelectromechanical systems (MEMS) technology. It can be adopted by other groups and customized for specific needs of individual experiments.

Original languageEnglish
Article number69
Pages (from-to)1-12
Number of pages12
JournalFrontiers in Systems Neuroscience
Volume9
Issue numberMAY
DOIs
Publication statusPublished - 2015 May 6
Externally publishedYes

Fingerprint

Optogenetics
Product Packaging
Light
Microelectrodes
Polymers
Technology
Costs and Cost Analysis

Keywords

  • Implantable neural interface
  • Microelectromechanical systems
  • Optogenetics
  • Optrode array
  • Switched-capacitor based stimulators
  • Wireless power transfer

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Developmental Neuroscience
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

Design, fabrication, and packaging of an integrated, wirelessly-powered optrode array for optogenetics application. / Kwon, Ki Yong; Lee, Hyung Min; Ghovanloo, Maysam; Weber, Arthur; Li, Wen.

In: Frontiers in Systems Neuroscience, Vol. 9, No. MAY, 69, 06.05.2015, p. 1-12.

Research output: Contribution to journalArticle

@article{1614712af5c84a9d9b234c08c5dc1923,
title = "Design, fabrication, and packaging of an integrated, wirelessly-powered optrode array for optogenetics application",
abstract = "The recent development of optogenetics has created an increased demand for advancing engineering tools for optical modulation of neural circuitry. This paper details the design, fabrication, integration, and packaging procedures of a wirelessly-powered, light emitting diode (LED) coupled optrode neural interface for optogenetic studies. The LED-coupled optrode array employs microscale LED (μLED) chips and polymer-based microwaveguides to deliver light into multi-level cortical networks, coupled with microelectrodes to record spontaneous changes in neural activity. An integrated, implantable, switched-capacitor based stimulator (SCS) system provides high instantaneous power to the μLEDs through an inductive link to emit sufficient light and evoke neural activities. The presented system is mechanically flexible, biocompatible, miniaturized, and lightweight, suitable for chronic implantation in small freely behaving animals. The design of this system is scalable and its manufacturing is cost effective through batch fabrication using microelectromechanical systems (MEMS) technology. It can be adopted by other groups and customized for specific needs of individual experiments.",
keywords = "Implantable neural interface, Microelectromechanical systems, Optogenetics, Optrode array, Switched-capacitor based stimulators, Wireless power transfer",
author = "Kwon, {Ki Yong} and Lee, {Hyung Min} and Maysam Ghovanloo and Arthur Weber and Wen Li",
year = "2015",
month = "5",
day = "6",
doi = "10.3389/fnsys.2015.00069",
language = "English",
volume = "9",
pages = "1--12",
journal = "Frontiers in Systems Neuroscience",
issn = "1662-5137",
publisher = "Frontiers Research Foundation",
number = "MAY",

}

TY - JOUR

T1 - Design, fabrication, and packaging of an integrated, wirelessly-powered optrode array for optogenetics application

AU - Kwon, Ki Yong

AU - Lee, Hyung Min

AU - Ghovanloo, Maysam

AU - Weber, Arthur

AU - Li, Wen

PY - 2015/5/6

Y1 - 2015/5/6

N2 - The recent development of optogenetics has created an increased demand for advancing engineering tools for optical modulation of neural circuitry. This paper details the design, fabrication, integration, and packaging procedures of a wirelessly-powered, light emitting diode (LED) coupled optrode neural interface for optogenetic studies. The LED-coupled optrode array employs microscale LED (μLED) chips and polymer-based microwaveguides to deliver light into multi-level cortical networks, coupled with microelectrodes to record spontaneous changes in neural activity. An integrated, implantable, switched-capacitor based stimulator (SCS) system provides high instantaneous power to the μLEDs through an inductive link to emit sufficient light and evoke neural activities. The presented system is mechanically flexible, biocompatible, miniaturized, and lightweight, suitable for chronic implantation in small freely behaving animals. The design of this system is scalable and its manufacturing is cost effective through batch fabrication using microelectromechanical systems (MEMS) technology. It can be adopted by other groups and customized for specific needs of individual experiments.

AB - The recent development of optogenetics has created an increased demand for advancing engineering tools for optical modulation of neural circuitry. This paper details the design, fabrication, integration, and packaging procedures of a wirelessly-powered, light emitting diode (LED) coupled optrode neural interface for optogenetic studies. The LED-coupled optrode array employs microscale LED (μLED) chips and polymer-based microwaveguides to deliver light into multi-level cortical networks, coupled with microelectrodes to record spontaneous changes in neural activity. An integrated, implantable, switched-capacitor based stimulator (SCS) system provides high instantaneous power to the μLEDs through an inductive link to emit sufficient light and evoke neural activities. The presented system is mechanically flexible, biocompatible, miniaturized, and lightweight, suitable for chronic implantation in small freely behaving animals. The design of this system is scalable and its manufacturing is cost effective through batch fabrication using microelectromechanical systems (MEMS) technology. It can be adopted by other groups and customized for specific needs of individual experiments.

KW - Implantable neural interface

KW - Microelectromechanical systems

KW - Optogenetics

KW - Optrode array

KW - Switched-capacitor based stimulators

KW - Wireless power transfer

UR - http://www.scopus.com/inward/record.url?scp=84930504704&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84930504704&partnerID=8YFLogxK

U2 - 10.3389/fnsys.2015.00069

DO - 10.3389/fnsys.2015.00069

M3 - Article

AN - SCOPUS:84930504704

VL - 9

SP - 1

EP - 12

JO - Frontiers in Systems Neuroscience

JF - Frontiers in Systems Neuroscience

SN - 1662-5137

IS - MAY

M1 - 69

ER -