TY - JOUR
T1 - Design of Magnetic-Plasmonic Nanoparticle Assemblies via Interface Engineering of Plasmonic Shells for Targeted Cancer Cell Imaging and Separation
AU - Kim, Myeong Soo
AU - Park, Bum Chul
AU - Kim, Yu Jin
AU - Lee, Ju Hun
AU - Koo, Thomas Myeongseok
AU - Ko, Min Jun
AU - Kim, Young Keun
N1 - Funding Information:
This research was supported by the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (2019R1A2C3006587) and the Ministry of Trade, Industry, and Energy (MOTIE, Korea) under the Industrial Technology Innovation Program (10080408). The authors are grateful to Prof. Soong Ju Oh and Prof. Kyu Back Lee for their helpful feedback on this study.
Funding Information:
This research was supported by the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (2019R1A2C3006587) and the Ministry of Trade, Industry, and Energy (MOTIE, Korea) under the Industrial Technology Innovation Program (10080408). The authors are grateful to Prof. Soong Ju Oh and Prof. Kyu Back Lee for their helpful feedback on this study.
Publisher Copyright:
© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/5/1
Y1 - 2020/5/1
N2 - Magnetic-plasmonic nanoparticles have received considerable attention for widespread applications. These nanoparticles (NPs) exhibiting surface-enhanced Raman scattering (SERS) activities are developed due to their potential in bio-sensing applicable in non-destructive and sensitive analysis with target-specific separation. However, it is challenging to synthesize these NPs that simultaneously exhibit low remanence, maximized magnetic content, plasmonic coverage with abundant hotspots, and structural uniformity. Here, a method that involves the conjugation of a magnetic template with gold seeds via chemical binding and seed-mediated growth is proposed, with the objective of obtaining plasmonic nanostructures with abundant hotspots on a magnetic template. To obtain a clean surface for directly functionalizing ligands and enhancing the Raman intensity, an additional growth step of gold (Au) and/or silver (Ag) atoms is proposed after modifying the Raman molecules on the as-prepared magnetic-plasmonic nanoparticles. Importantly, one-sided silver growth occurred in an environment where gold facets are blocked by Raman molecules; otherwise, the gold growth is layer-by-layer. Moreover, simultaneous reduction by gold and silver ions allowed for the formation of a uniform bimetallic layer. The enhancement factor of the nanoparticles with a bimetallic layer is approximately 107. The SERS probes functionalized cyclic peptides are employed for targeted cancer-cell imaging and separation.
AB - Magnetic-plasmonic nanoparticles have received considerable attention for widespread applications. These nanoparticles (NPs) exhibiting surface-enhanced Raman scattering (SERS) activities are developed due to their potential in bio-sensing applicable in non-destructive and sensitive analysis with target-specific separation. However, it is challenging to synthesize these NPs that simultaneously exhibit low remanence, maximized magnetic content, plasmonic coverage with abundant hotspots, and structural uniformity. Here, a method that involves the conjugation of a magnetic template with gold seeds via chemical binding and seed-mediated growth is proposed, with the objective of obtaining plasmonic nanostructures with abundant hotspots on a magnetic template. To obtain a clean surface for directly functionalizing ligands and enhancing the Raman intensity, an additional growth step of gold (Au) and/or silver (Ag) atoms is proposed after modifying the Raman molecules on the as-prepared magnetic-plasmonic nanoparticles. Importantly, one-sided silver growth occurred in an environment where gold facets are blocked by Raman molecules; otherwise, the gold growth is layer-by-layer. Moreover, simultaneous reduction by gold and silver ions allowed for the formation of a uniform bimetallic layer. The enhancement factor of the nanoparticles with a bimetallic layer is approximately 107. The SERS probes functionalized cyclic peptides are employed for targeted cancer-cell imaging and separation.
KW - bimetallic layers
KW - island growth
KW - layer-by-layer growth
KW - surface ligands
KW - surface plasmon resonance
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U2 - 10.1002/smll.202001103
DO - 10.1002/smll.202001103
M3 - Article
C2 - 32329574
AN - SCOPUS:85083772317
VL - 16
JO - Small
JF - Small
SN - 1613-6810
IS - 20
M1 - 2001103
ER -