Design of the long-term observational cohort study with recombinant human growth hormone in korean children: LG growth study

Sochung Chung, Jae Ho Yoo, Jin Ho Choi, Young-Jun Rhie, Hyun Wook Chae, Jae Hyun Kim, Il Tae Hwang, Choong Ho Shin, Eun Young Kim, Kee Hyoung Lee

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Purpose: Regarding recombinant human growth hormone (rhGH) use in the pediatric population, no long-term follow-up data are available for Korean patients. To fill in the gap of knowledge, a registry study (LG Growth Study) was initiated to assess the safety and effectiveness of four types of rhGH products in real-life settings. Methods: A total of 4,000 children will be registered and prospectively followed up at 6-month intervals until 2 years after epiphyseal closure to collect data on treatment and adverse events, with primary interest in malignancies and growth outcomes. Results: As of 22 March 2017, approximately 50% (2,024) of the target number of patients have been included in the analysis set: growth hormone deficiency, 1,297 (64.1%); idiopathic short stature, 315 (15.6%); small for gestational age, 206 (10.2%); Turner syndrome, 197 (9.7%); and chronic renal failure, 9 (0.4%). At baseline, median age (years) was 8 (interquartile range [IQR], 5–11); 52% (1,048) were boys; and the majority were at Tanner stage I (83% based on breast/external genitalia, 97% on pubic hair). Median height standard deviation score was -2.26 (IQR, -2.69 to -2.0), and median bone age delay (years) was -1.46 (IQR, -2.26 to -0.78). Conclusion: This registry study will provide the opportunity to assess the risk of malignancies as well as the general safety data in Korean pediatric patients receiving rhGH. In addition, the long-term effectiveness of rhGH and comparative data between different disease entities will provide practical insight on the standard rhGH treatment.

Original languageEnglish
Pages (from-to)43-50
Number of pages8
JournalAnnals of Pediatric Endocrinology and Metabolism
Volume23
Issue number1
DOIs
Publication statusPublished - 2018 Mar 1

Keywords

  • Chronic renal failure
  • Growth hormone deficiency
  • Idiopathic short stature
  • Small for gestational age
  • Turner syndrome

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism

Fingerprint Dive into the research topics of 'Design of the long-term observational cohort study with recombinant human growth hormone in korean children: LG growth study'. Together they form a unique fingerprint.

  • Cite this