Design, syntheses and biological evaluations of nonpeptidic caspase 3 inhibitors

Eun sook Kim, Sung eun Yoo, Kyu Yang Yi, Sunkyung Lee, Jae sung Noh, Yong Sam Jung, Eunhee Kim, Nakcheol Jeong

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Caspase 3, a member of cysteine protease family, is well known as a major apoptosis effector and is involved in cell death as a result of ischemic diseases such as stroke and myocardial infarction, therefore the inhibition of caspase 3 may protect those apoptotic cell damages. During the high-throughput screening of the compounds from the Korea Chemical Bank, berberine derivatives (A and B), an isoquinoline alkaloid, have been identified as potential inhibitors for caspase 3. Based on this finding we carried out molecular modeling study to identify the pharmacophoric elements of berberine structure which interact with a substrate-recognition binding site of caspase 3 and came up with several novel scaffolds. In this report, we will discuss the molecular modeling, syntheses and the enzyme inhibitory activities of these novel compounds.

Original languageEnglish
Pages (from-to)1003-1010
Number of pages8
JournalBulletin of the Korean Chemical Society
Volume23
Issue number7
Publication statusPublished - 2002 Jul 20
Externally publishedYes

Fingerprint

Caspase 3
Berberine
Molecular modeling
Cysteine Proteases
Enzyme activity
Cell death
Alkaloids
Scaffolds
Screening
Binding Sites
Cells
Throughput
Apoptosis
Derivatives
Substrates

Keywords

  • Apoptosis
  • Caspase 3
  • Isoquinoline derivatives
  • Nonpeptidic inhibitor

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Kim, E. S., Yoo, S. E., Yi, K. Y., Lee, S., Noh, J. S., Jung, Y. S., ... Jeong, N. (2002). Design, syntheses and biological evaluations of nonpeptidic caspase 3 inhibitors. Bulletin of the Korean Chemical Society, 23(7), 1003-1010.

Design, syntheses and biological evaluations of nonpeptidic caspase 3 inhibitors. / Kim, Eun sook; Yoo, Sung eun; Yi, Kyu Yang; Lee, Sunkyung; Noh, Jae sung; Jung, Yong Sam; Kim, Eunhee; Jeong, Nakcheol.

In: Bulletin of the Korean Chemical Society, Vol. 23, No. 7, 20.07.2002, p. 1003-1010.

Research output: Contribution to journalArticle

Kim, ES, Yoo, SE, Yi, KY, Lee, S, Noh, JS, Jung, YS, Kim, E & Jeong, N 2002, 'Design, syntheses and biological evaluations of nonpeptidic caspase 3 inhibitors', Bulletin of the Korean Chemical Society, vol. 23, no. 7, pp. 1003-1010.
Kim ES, Yoo SE, Yi KY, Lee S, Noh JS, Jung YS et al. Design, syntheses and biological evaluations of nonpeptidic caspase 3 inhibitors. Bulletin of the Korean Chemical Society. 2002 Jul 20;23(7):1003-1010.
Kim, Eun sook ; Yoo, Sung eun ; Yi, Kyu Yang ; Lee, Sunkyung ; Noh, Jae sung ; Jung, Yong Sam ; Kim, Eunhee ; Jeong, Nakcheol. / Design, syntheses and biological evaluations of nonpeptidic caspase 3 inhibitors. In: Bulletin of the Korean Chemical Society. 2002 ; Vol. 23, No. 7. pp. 1003-1010.
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