Design, synthesis, and evaluation of peptidyl fluorescent probe for Zn2+ in aqueous solution

Bishnu Prasad Joshi, Won Mi Cho, Jong Seung Kim, Juyoung Yoon, Keun Hyeung Lee

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

A new fluorescent peptide probe for the detection of Zn2+ was synthesized on the basis of zinc binding ligands in zinc enzymes. The peptide that has a unique amino acid sequence displayed a great selectivity for Zn2+ in the presence of several transition metal ions in aqueous solution. The reversibility, binding stoichiometry, binding affinity, and pH sensitivity of the sensor were studied. Further, on-bead application of the peptide as chemosensors was demonstrated.

Original languageEnglish
Pages (from-to)6425-6429
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume17
Issue number23
DOIs
Publication statusPublished - 2007 Dec 1

Keywords

  • Dansyl
  • Fluorescence
  • Metal
  • Peptide sensor
  • Probe
  • Selectivity
  • Zn

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Fingerprint Dive into the research topics of 'Design, synthesis, and evaluation of peptidyl fluorescent probe for Zn<sup>2+</sup> in aqueous solution'. Together they form a unique fingerprint.

  • Cite this