Design, synthesis, and preliminary cytotoxicity evaluation of new diarylureas and diarylamides possessing 1,3,4-triarylpyrazole scaffold

Won Kyoung Choi, Mohammed I. El-Gamal, Hong Seok Choi, Jun Hee Hong, Daejin Baek, Kihang Choi, Chang Hyun Oh

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

A series of new diarylureas and diarylamides possessing 1,3,4-triarylpyrazole scaffold was synthesized and their in vitro antiproliferative activities against A375P human melanoma cell line and NCI-60 cell line panel were tested. Compounds 9, 11, 12, 14, and 17-21 showed superior potency against A375P to Sorafenib. Over the NCI-60 cancer cell line panel, compound 14 possessing a methoxy group, amide linker, and 4-chloro-3- (trifluoromethyl)phenyl terminal ring showed the highest potency and broad-spectrum anticancer activity. Compound 13 showed high selectivity towards leukemia subpanel over other cancer types.

Original languageEnglish
Pages (from-to)2991-2998
Number of pages8
JournalBulletin of the Korean Chemical Society
Volume33
Issue number9
DOIs
Publication statusPublished - 2012 Sep 20

Keywords

  • 1,3,4-triarylpyrazole
  • A375P
  • Anticancer
  • Diarylamide
  • Diarylurea

ASJC Scopus subject areas

  • Chemistry(all)

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