Design, synthesis, and preliminary cytotoxicity evaluation of new diarylureas and diarylamides possessing 1,3,4-triarylpyrazole scaffold

Won Kyoung Choi, Mohammed I. El-Gamal, Hong Seok Choi, Jun Hee Hong, Daejin Baek, Kihang Choi, Chang Hyun Oh

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A series of new diarylureas and diarylamides possessing 1,3,4-triarylpyrazole scaffold was synthesized and their in vitro antiproliferative activities against A375P human melanoma cell line and NCI-60 cell line panel were tested. Compounds 9, 11, 12, 14, and 17-21 showed superior potency against A375P to Sorafenib. Over the NCI-60 cancer cell line panel, compound 14 possessing a methoxy group, amide linker, and 4-chloro-3- (trifluoromethyl)phenyl terminal ring showed the highest potency and broad-spectrum anticancer activity. Compound 13 showed high selectivity towards leukemia subpanel over other cancer types.

Original languageEnglish
Pages (from-to)2991-2998
Number of pages8
JournalBulletin of the Korean Chemical Society
Volume33
Issue number9
DOIs
Publication statusPublished - 2012 Sep 20

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Cytotoxicity
Scaffolds
Cells
Amides

Keywords

  • 1,3,4-triarylpyrazole
  • A375P
  • Anticancer
  • Diarylamide
  • Diarylurea

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Design, synthesis, and preliminary cytotoxicity evaluation of new diarylureas and diarylamides possessing 1,3,4-triarylpyrazole scaffold. / Choi, Won Kyoung; El-Gamal, Mohammed I.; Choi, Hong Seok; Hong, Jun Hee; Baek, Daejin; Choi, Kihang; Oh, Chang Hyun.

In: Bulletin of the Korean Chemical Society, Vol. 33, No. 9, 20.09.2012, p. 2991-2998.

Research output: Contribution to journalArticle

Choi, Won Kyoung ; El-Gamal, Mohammed I. ; Choi, Hong Seok ; Hong, Jun Hee ; Baek, Daejin ; Choi, Kihang ; Oh, Chang Hyun. / Design, synthesis, and preliminary cytotoxicity evaluation of new diarylureas and diarylamides possessing 1,3,4-triarylpyrazole scaffold. In: Bulletin of the Korean Chemical Society. 2012 ; Vol. 33, No. 9. pp. 2991-2998.
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