TY - JOUR
T1 - Design, synthesis, and preliminary cytotoxicity evaluation of new diarylureas and diarylamides possessing 1,3,4-triarylpyrazole scaffold
AU - Choi, Won Kyoung
AU - El-Gamal, Mohammed I.
AU - Choi, Hong Seok
AU - Hong, Jun Hee
AU - Baek, Daejin
AU - Choi, Kihang
AU - Oh, Chang Hyun
N1 - Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2012/9/20
Y1 - 2012/9/20
N2 - A series of new diarylureas and diarylamides possessing 1,3,4-triarylpyrazole scaffold was synthesized and their in vitro antiproliferative activities against A375P human melanoma cell line and NCI-60 cell line panel were tested. Compounds 9, 11, 12, 14, and 17-21 showed superior potency against A375P to Sorafenib. Over the NCI-60 cancer cell line panel, compound 14 possessing a methoxy group, amide linker, and 4-chloro-3- (trifluoromethyl)phenyl terminal ring showed the highest potency and broad-spectrum anticancer activity. Compound 13 showed high selectivity towards leukemia subpanel over other cancer types.
AB - A series of new diarylureas and diarylamides possessing 1,3,4-triarylpyrazole scaffold was synthesized and their in vitro antiproliferative activities against A375P human melanoma cell line and NCI-60 cell line panel were tested. Compounds 9, 11, 12, 14, and 17-21 showed superior potency against A375P to Sorafenib. Over the NCI-60 cancer cell line panel, compound 14 possessing a methoxy group, amide linker, and 4-chloro-3- (trifluoromethyl)phenyl terminal ring showed the highest potency and broad-spectrum anticancer activity. Compound 13 showed high selectivity towards leukemia subpanel over other cancer types.
KW - 1,3,4-triarylpyrazole
KW - A375P
KW - Anticancer
KW - Diarylamide
KW - Diarylurea
UR - http://www.scopus.com/inward/record.url?scp=84866406828&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84866406828&partnerID=8YFLogxK
U2 - 10.5012/bkcs.2012.33.9.2991
DO - 10.5012/bkcs.2012.33.9.2991
M3 - Article
AN - SCOPUS:84866406828
VL - 33
SP - 2991
EP - 2998
JO - Bulletin of the Korean Chemical Society
JF - Bulletin of the Korean Chemical Society
SN - 0253-2964
IS - 9
ER -