Detection of Aβ plaques in mouse brain by using a disaggregation- induced fluorescence-enhancing probe

Yeon Ok Lee, Jung Won Shin, C. Yi, Yun Hak Lee, Nak Won Sohn, Chulhun Kang, Jong Seung Kim

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

We herein report a fluorescence probe 1 capable of detecting water-soluble oligomeric Aβ aggregates and Aβ fibrils. Upon injection into Aβ42-challenged mouse brains, probe 1 shows increased fluorescence intensity, indicating its facile binding to extracellular Aβ fibrils in brain tissues.

Original languageEnglish
Pages (from-to)5741-5744
Number of pages4
JournalChemical Communications
Volume50
Issue number43
DOIs
Publication statusPublished - 2014 Jun 1

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Brain
Fluorescence
Tissue
Injections
Water

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Ceramics and Composites
  • Electronic, Optical and Magnetic Materials
  • Surfaces, Coatings and Films
  • Materials Chemistry
  • Metals and Alloys

Cite this

Detection of Aβ plaques in mouse brain by using a disaggregation- induced fluorescence-enhancing probe. / Lee, Yeon Ok; Shin, Jung Won; Yi, C.; Lee, Yun Hak; Sohn, Nak Won; Kang, Chulhun; Kim, Jong Seung.

In: Chemical Communications, Vol. 50, No. 43, 01.06.2014, p. 5741-5744.

Research output: Contribution to journalArticle

Lee, Yeon Ok ; Shin, Jung Won ; Yi, C. ; Lee, Yun Hak ; Sohn, Nak Won ; Kang, Chulhun ; Kim, Jong Seung. / Detection of Aβ plaques in mouse brain by using a disaggregation- induced fluorescence-enhancing probe. In: Chemical Communications. 2014 ; Vol. 50, No. 43. pp. 5741-5744.
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