Detection of Hantaan virus RNA from anti-Hantaan virus IgG seronegative rodents in an area of high endemicity in Republic of Korea

Jin Sun No, Won keun Kim, Jeong Ah Kim, Seung Ho Lee, Sook Young Lee, Ji Hye Kim, Jeong Hoon Kho, Daesang Lee, Dong Hyun Song, Se Hun Gu, Seong Tae Jeong, Heung Chul Kim, Terry A. Klein, Jin Won Song

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Hantaan virus (HTNV), of the family Bunyaviridae, causes hemorrhagic fever with renal syndrome (HFRS) in humans. Although the majority of epidemiologic studies have found that rodents are seropositive for hantavirus-specific immunoglobulin, the discovery of hantavirus RNA in seronegative hosts has led to an investigation of the presence of HTNV RNA in rodents captured in HFRS endemic areas. HTNV RNA was detected in seven (3.8%) of 186 anti-HTNV IgG seronegative rodents in Republic of Korea (ROK) during 2013-2014. RT-qPCR for HTNV RNA revealed dynamic virus-host interactions of HTNV in areas of high endemicity, providing important insights into the epidemiology of hantaviruses.

Original languageEnglish
Pages (from-to)268-271
Number of pages4
JournalMicrobiology and Immunology
Volume60
Issue number4
DOIs
Publication statusPublished - 2016 Apr 1

Keywords

  • Epidemiology
  • Hantaan virus
  • Virus-host interaction

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Virology

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  • Cite this

    No, J. S., Kim, W. K., Kim, J. A., Lee, S. H., Lee, S. Y., Kim, J. H., Kho, J. H., Lee, D., Song, D. H., Gu, S. H., Jeong, S. T., Kim, H. C., Klein, T. A., & Song, J. W. (2016). Detection of Hantaan virus RNA from anti-Hantaan virus IgG seronegative rodents in an area of high endemicity in Republic of Korea. Microbiology and Immunology, 60(4), 268-271. https://doi.org/10.1111/1348-0421.12370