Detection of prodromal Alzheimer's disease via pattern classification of magnetic resonance imaging

Christos Davatzikos, Yong Fan, Xiaoying Wu, Dinggang Shen, Susan M. Resnick

Research output: Contribution to journalArticle

274 Citations (Scopus)


We report evidence that computer-based high-dimensional pattern classification of magnetic resonance imaging (MRI) detects patterns of brain structure characterizing mild cognitive impairment (MCI), often a prodromal phase of Alzheimer's disease (AD). Ninety percent diagnostic accuracy was achieved, using cross-validation, for 30 participants in the Baltimore Longitudinal Study of Aging. Retrospective evaluation of serial scans obtained during prior years revealed gradual increases in structural abnormality for the MCI group, often before clinical symptoms, but slower increase for individuals remaining cognitively normal. Detecting complex patterns of brain abnormality in very early stages of cognitive impairment has pivotal importance for the detection and management of AD.

Original languageEnglish
Pages (from-to)514-523
Number of pages10
JournalNeurobiology of Aging
Issue number4
Publication statusPublished - 2008 Apr 1
Externally publishedYes



  • MCI
  • MRI
  • Pattern recognition
  • Prodromal Alzheimer's disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)

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