Development and psychometric evaluation of a chronic liver disease-specific quality of life questionnaire

Eun Hyun Lee, Jae Youn Cheong, Sung Won Cho, Ki Baik Hahm, Hak Yang Kim, Jong Jae Park, Dong Ho Lee, Seong Kook Kim, Seok Reyol Choi, Soo Teik Lee, Seong Mi Moon

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5 Citations (Scopus)

Abstract

Background and Aims: There has been no reliable and valid instrument to measure health-related quality of life for Asian patients with chronic liver disease. The aim of the present study was to develop and evaluate a chronic liver disease-specific quality of life (CLD-QOL) questionnaire for Korean patients with chronic liver disease. Methods: Content-validated items were evaluated psychometrically in 271 patients with chronic liver disease recruited from seven university hospitals in Korea. The participants were asked to complete a preliminary questionnaire comprising the content-validated items and the Short Form-36 Health Survey. The Child-Pugh classification was used to classify the severity of liver cirrhosis. Results: Factor analysis extracted a five-factor solution from 27 preliminary items, which were generated by an expert panel and a pilot study, but factor and a multidimensional scaling analysis revealed that four items were not loaded significantly on any factor, suggesting that the four items might be heterogeneous. After deletion of these four items, a multiscaling analysis strongly supported item convergence and discriminant validity. The CLD-QOL was associated significantly with the Child-Pugh classification and the type of patient status (inpatient/outpatient) and was moderately correlated with the subscales of the Short Form-36 Health Survey. The values of Cronbach's alpha for the subscales of the novel CLD-QOL questionnaire were all greater than 0.70. Conclusions: The novel CLD-QOL questionnaire we developed is an easily applicable tool that exhibits excellent psychometric properties for Korean patients with chronic liver disease. It is recommended for the CLD-QOL to apply for Asian patients with chronic liver disease.

Original languageEnglish
Pages (from-to)231-238
Number of pages8
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume23
Issue number2
DOIs
Publication statusPublished - 2008 Feb

Keywords

  • Chronic liver disease
  • Health-related quality of life
  • Reliability
  • Validity

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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    Lee, E. H., Cheong, J. Y., Cho, S. W., Hahm, K. B., Kim, H. Y., Park, J. J., Lee, D. H., Kim, S. K., Choi, S. R., Lee, S. T., & Moon, S. M. (2008). Development and psychometric evaluation of a chronic liver disease-specific quality of life questionnaire. Journal of Gastroenterology and Hepatology (Australia), 23(2), 231-238. https://doi.org/10.1111/j.1440-1746.2007.05034.x