Development of a BODIPY-based fluorescent probe for imaging pathological tau aggregates in live cells

Sungsu Lim, Md Mamunul Haque, Dongdong Su, Dohee Kim, Jun Seok Lee, Young Tae Chang, Yun Kyung Kim

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)

Abstract

Neuronal accumulation of tau aggregates is a pathological hallmark in multiple neurodegenerative disorders, collectively called tauopathies. A tau aggregation sensor that can monitor abnormal tau aggregation in neurons would facilitate the study of tau aggregation processes and the discovery of tau aggregation blockers. Here, we describe a BODIPY-fluorescence sensor (BD-tau) that selectively responds to pathological tau aggregates in live cells.

Original languageEnglish
Pages (from-to)1607-1610
Number of pages4
JournalChemical Communications
Volume53
Issue number10
DOIs
Publication statusPublished - 2017
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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