Development of a local antibiotic delivery system using fibrin glue

Bong Gyu Yu, Ick Chan Kwon, Yong Hee Kim, Dong Keun Han, Ki Dong Park, Kun Han, Seo Young Jeong

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Fibrin glue (FG) has been successfully used in a wide range of surgical fields such as skin graft fixation, nerve repair, cartilage reattachment and microvascular anastomoses. The sustained release of antibiotics from FG for a longer period is desirable to avoid bacterial infection after application. Ampicillin sodium (AMP-Na) was selected as a model antibiotic and incorporated into FG. The incorporation of AMP-Na was attempted in two different ways. One was incorporation of AMP-Na in a dispersed state with the modification of the preparation method of FG. The other was incorporation of bovine serum albumin microspheres (BSA-MS) containing AMP-Na. The in vitro release of AMP-Na from various FGs and BSA MS was examined. The modifications of FG were found not to be appropriate methods to achieve sustained release of AMP-Na. The incorporation of crosslinked BSA-MS containing AMP-Na into FG was found to reduce the initial rapid lease of AMP-Na and retarded release of AMP-Na.

Original languageEnglish
Pages (from-to)65-70
Number of pages6
JournalJournal of Controlled Release
Volume39
Issue number1
DOIs
Publication statusPublished - 1996 Mar

Keywords

  • Ampicillin sodium
  • Bovine serum albumin
  • Fibrin glue
  • Microsphere
  • Sustained release

ASJC Scopus subject areas

  • Pharmaceutical Science

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  • Cite this

    Yu, B. G., Kwon, I. C., Kim, Y. H., Han, D. K., Park, K. D., Han, K., & Jeong, S. Y. (1996). Development of a local antibiotic delivery system using fibrin glue. Journal of Controlled Release, 39(1), 65-70. https://doi.org/10.1016/0168-3659(95)00139-5