Development of a local antibiotic delivery system using fibrin glue

Bong Gyu Yu, Ick Chan Kwon, Yong Hee Kim, Dong Keun Han, Ki Dong Park, Kun Han, Seo Young Jeong

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Fibrin glue (FG) has been successfully used in a wide range of surgical fields such as skin graft fixation, nerve repair, cartilage reattachment and microvascular anastomoses. The sustained release of antibiotics from FG for a longer period is desirable to avoid bacterial infection after application. Ampicillin sodium (AMP-Na) was selected as a model antibiotic and incorporated into FG. The incorporation of AMP-Na was attempted in two different ways. One was incorporation of AMP-Na in a dispersed state with the modification of the preparation method of FG. The other was incorporation of bovine serum albumin microspheres (BSA-MS) containing AMP-Na. The in vitro release of AMP-Na from various FGs and BSA MS was examined. The modifications of FG were found not to be appropriate methods to achieve sustained release of AMP-Na. The incorporation of crosslinked BSA-MS containing AMP-Na into FG was found to reduce the initial rapid lease of AMP-Na and retarded release of AMP-Na.

Original languageEnglish
Pages (from-to)65-70
Number of pages6
JournalJournal of Controlled Release
Volume39
Issue number1
DOIs
Publication statusPublished - 1996 Mar 1
Externally publishedYes

Fingerprint

Fibrin Tissue Adhesive
Adenosine Monophosphate
Anti-Bacterial Agents
Bovine Serum Albumin
Microspheres
Ampicillin
Bacterial Infections
Cartilage
Transplants
Skin

Keywords

  • Ampicillin sodium
  • Bovine serum albumin
  • Fibrin glue
  • Microsphere
  • Sustained release

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Yu, B. G., Kwon, I. C., Kim, Y. H., Han, D. K., Park, K. D., Han, K., & Jeong, S. Y. (1996). Development of a local antibiotic delivery system using fibrin glue. Journal of Controlled Release, 39(1), 65-70. https://doi.org/10.1016/0168-3659(95)00139-5

Development of a local antibiotic delivery system using fibrin glue. / Yu, Bong Gyu; Kwon, Ick Chan; Kim, Yong Hee; Han, Dong Keun; Park, Ki Dong; Han, Kun; Jeong, Seo Young.

In: Journal of Controlled Release, Vol. 39, No. 1, 01.03.1996, p. 65-70.

Research output: Contribution to journalArticle

Yu, BG, Kwon, IC, Kim, YH, Han, DK, Park, KD, Han, K & Jeong, SY 1996, 'Development of a local antibiotic delivery system using fibrin glue', Journal of Controlled Release, vol. 39, no. 1, pp. 65-70. https://doi.org/10.1016/0168-3659(95)00139-5
Yu, Bong Gyu ; Kwon, Ick Chan ; Kim, Yong Hee ; Han, Dong Keun ; Park, Ki Dong ; Han, Kun ; Jeong, Seo Young. / Development of a local antibiotic delivery system using fibrin glue. In: Journal of Controlled Release. 1996 ; Vol. 39, No. 1. pp. 65-70.
@article{f7443c4905be4898bbadb4c9fa35d389,
title = "Development of a local antibiotic delivery system using fibrin glue",
abstract = "Fibrin glue (FG) has been successfully used in a wide range of surgical fields such as skin graft fixation, nerve repair, cartilage reattachment and microvascular anastomoses. The sustained release of antibiotics from FG for a longer period is desirable to avoid bacterial infection after application. Ampicillin sodium (AMP-Na) was selected as a model antibiotic and incorporated into FG. The incorporation of AMP-Na was attempted in two different ways. One was incorporation of AMP-Na in a dispersed state with the modification of the preparation method of FG. The other was incorporation of bovine serum albumin microspheres (BSA-MS) containing AMP-Na. The in vitro release of AMP-Na from various FGs and BSA MS was examined. The modifications of FG were found not to be appropriate methods to achieve sustained release of AMP-Na. The incorporation of crosslinked BSA-MS containing AMP-Na into FG was found to reduce the initial rapid lease of AMP-Na and retarded release of AMP-Na.",
keywords = "Ampicillin sodium, Bovine serum albumin, Fibrin glue, Microsphere, Sustained release",
author = "Yu, {Bong Gyu} and Kwon, {Ick Chan} and Kim, {Yong Hee} and Han, {Dong Keun} and Park, {Ki Dong} and Kun Han and Jeong, {Seo Young}",
year = "1996",
month = "3",
day = "1",
doi = "10.1016/0168-3659(95)00139-5",
language = "English",
volume = "39",
pages = "65--70",
journal = "Journal of Controlled Release",
issn = "0168-3659",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Development of a local antibiotic delivery system using fibrin glue

AU - Yu, Bong Gyu

AU - Kwon, Ick Chan

AU - Kim, Yong Hee

AU - Han, Dong Keun

AU - Park, Ki Dong

AU - Han, Kun

AU - Jeong, Seo Young

PY - 1996/3/1

Y1 - 1996/3/1

N2 - Fibrin glue (FG) has been successfully used in a wide range of surgical fields such as skin graft fixation, nerve repair, cartilage reattachment and microvascular anastomoses. The sustained release of antibiotics from FG for a longer period is desirable to avoid bacterial infection after application. Ampicillin sodium (AMP-Na) was selected as a model antibiotic and incorporated into FG. The incorporation of AMP-Na was attempted in two different ways. One was incorporation of AMP-Na in a dispersed state with the modification of the preparation method of FG. The other was incorporation of bovine serum albumin microspheres (BSA-MS) containing AMP-Na. The in vitro release of AMP-Na from various FGs and BSA MS was examined. The modifications of FG were found not to be appropriate methods to achieve sustained release of AMP-Na. The incorporation of crosslinked BSA-MS containing AMP-Na into FG was found to reduce the initial rapid lease of AMP-Na and retarded release of AMP-Na.

AB - Fibrin glue (FG) has been successfully used in a wide range of surgical fields such as skin graft fixation, nerve repair, cartilage reattachment and microvascular anastomoses. The sustained release of antibiotics from FG for a longer period is desirable to avoid bacterial infection after application. Ampicillin sodium (AMP-Na) was selected as a model antibiotic and incorporated into FG. The incorporation of AMP-Na was attempted in two different ways. One was incorporation of AMP-Na in a dispersed state with the modification of the preparation method of FG. The other was incorporation of bovine serum albumin microspheres (BSA-MS) containing AMP-Na. The in vitro release of AMP-Na from various FGs and BSA MS was examined. The modifications of FG were found not to be appropriate methods to achieve sustained release of AMP-Na. The incorporation of crosslinked BSA-MS containing AMP-Na into FG was found to reduce the initial rapid lease of AMP-Na and retarded release of AMP-Na.

KW - Ampicillin sodium

KW - Bovine serum albumin

KW - Fibrin glue

KW - Microsphere

KW - Sustained release

UR - http://www.scopus.com/inward/record.url?scp=0029933344&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029933344&partnerID=8YFLogxK

U2 - 10.1016/0168-3659(95)00139-5

DO - 10.1016/0168-3659(95)00139-5

M3 - Article

AN - SCOPUS:0029933344

VL - 39

SP - 65

EP - 70

JO - Journal of Controlled Release

JF - Journal of Controlled Release

SN - 0168-3659

IS - 1

ER -